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ECOLI:ARCA

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Species (Taxon ID) Escherichia coli (strain K12). (83333)
Gene Name(s) arcA (synonyms: cpxC, dye, fexA, msp, seg, sfrA)
Protein Name(s) Aerobic respiration control protein ArcA

Dye resistance protein

External Links
UniProt P0A9Q1
EMBL M10044
U14003
U00096
AP009048
L34010
PIR A03561
RefSeq NP_418818.1
YP_492531.1
PDB 1XHE
1XHF
PDBsum 1XHE
1XHF
ProteinModelPortal P0A9Q1
SMR P0A9Q1
DIP DIP-36035N
IntAct P0A9Q1
STRING 511145.b4401
SWISS-2DPAGE P0A9Q1
PaxDb P0A9Q1
PRIDE P0A9Q1
EnsemblBacteria AAC77354
BAE78390
GeneID 12930392
948874
KEGG ecj:Y75_p4285
eco:b4401
PATRIC 32124420
EchoBASE EB0059
EcoGene EG10061
eggNOG COG0745
HOGENOM HOG000034819
InParanoid P0A9Q1
KO K07773
OMA FLECEGF
OrthoDB EOG6G4VQG
PhylomeDB P0A9Q1
BioCyc EcoCyc:ARCA-MONOMER
ECOL316407:JW4364-MONOMER
EvolutionaryTrace P0A9Q1
PRO PR:P0A9Q1
Proteomes UP000000318
UP000000625
Genevestigator P0A9Q1
GO GO:0005737
GO:0003677
GO:0042802
GO:0000156
GO:0003700
GO:0045892
GO:0000160
GO:0045893
GO:0006355
GO:0006351
Gene3D 1.10.10.10
InterPro IPR011006
IPR001867
IPR016032
IPR001789
IPR011991
Pfam PF00072
PF00486
SMART SM00448
SM00862
SUPFAM SSF46894
SSF52172
PROSITE PS50110

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0032993

protein-DNA complex

PMID:24146625[1]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.3

C

Seeded From UniProt

complete

enables

GO:0001217

DNA-binding transcription repressor activity

PMID:24146625[1]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.3

F

Seeded From UniProt

complete

enables

GO:0000976

transcription regulatory region sequence-specific DNA binding

PMID:24146625[1]

ECO:0005631

DNAse footprinting evidence used in manual assertion

RefSeq:NC_000913.3

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10020
EcoGene:EG10061
EcoGene:EG10731
EcoGene:EG11618
PANTHER:PTN000724188
UniProtKB:P9WGM1

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10020
EcoGene:EG10061
EcoGene:EG14045
PANTHER:PTN000724188

F

Seeded From UniProt

complete

enables

GO:0000156

phosphorelay response regulator activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG10061
EcoGene:EG10672
EcoGene:EG11615
EcoGene:EG12615
PANTHER:PTN000724188
UniProtKB:O07776
UniProtKB:P37478
UniProtKB:Q9I2U3

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:18631241[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P0A9Q1

F

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:2964639[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:14711822[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:2984198[6]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0AA16

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:2964639[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:14711822[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

PMID:2984198[6]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0AA16

P

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:16849788[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:18304323[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:2964639[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:14711822[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

PMID:2984198[6]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P0AA16

F

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

PMID:1512197[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000156

phosphorelay response regulator activity

PMID:1512197[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001789
InterPro:IPR001867

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001867
InterPro:IPR016032

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001867
InterPro:IPR016032

P

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0902

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Park, DM et al. (2013) The bacterial response regulator ArcA uses a diverse binding site architecture to regulate carbon oxidation globally. PLoS Genet. 9 e1003839 PubMed GONUTS page
  2. 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. Gao, R et al. (2008) System-level mapping of Escherichia coli response regulator dimerization with FRET hybrids. Mol. Microbiol. 69 1358-72 PubMed GONUTS page
  4. 4.0 4.1 4.2 Iuchi, S & Lin, EC (1988) arcA (dye), a global regulatory gene in Escherichia coli mediating repression of enzymes in aerobic pathways. Proc. Natl. Acad. Sci. U.S.A. 85 1888-92 PubMed GONUTS page
  5. 5.0 5.1 5.2 Liu, X & De Wulf, P (2004) Probing the ArcA-P modulon of Escherichia coli by whole genome transcriptional analysis and sequence recognition profiling. J. Biol. Chem. 279 12588-97 PubMed GONUTS page
  6. 6.0 6.1 6.2 Drury, LS & Buxton, RS (1985) DNA sequence analysis of the dye gene of Escherichia coli reveals amino acid homology between the dye and OmpR proteins. J. Biol. Chem. 260 4236-42 PubMed GONUTS page
  7. Cho, BK et al. (2006) Transcriptional regulation of the fad regulon genes of Escherichia coli by ArcA. Microbiology (Reading, Engl.) 152 2207-19 PubMed GONUTS page
  8. Ishihama, Y et al. (2008) Protein abundance profiling of the Escherichia coli cytosol. BMC Genomics 9 102 PubMed GONUTS page
  9. 9.0 9.1 Iuchi, S & Lin, EC (1992) Purification and phosphorylation of the Arc regulatory components of Escherichia coli. J. Bacteriol. 174 5617-23 PubMed GONUTS page