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ECO24:SYA

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Species (Taxon ID) Escherichia coli O139:H28 (strain E24377A / ETEC). (331111)
Gene Name(s) alaS (ECO:0000255 with HAMAP-Rule:MF_00036)
Protein Name(s) Alanine--tRNA ligase (ECO:0000255 with HAMAP-Rule:MF_00036)

Alanyl-tRNA synthetase (ECO:0000255 with HAMAP-Rule:MF_00036) AlaRS (ECO:0000255 with HAMAP-Rule:MF_00036)

External Links
UniProt A7ZQC5
EMBL CP000800
RefSeq YP_001464004.1
ProteinModelPortal A7ZQC5
SMR A7ZQC5
STRING 331111.EcE24377A_2980
EnsemblBacteria ABV20043
GeneID 5587731
KEGG ecw:EcE24377A_2980
PATRIC 18295264
eggNOG COG0013
HOGENOM HOG000156964
KO K01872
OMA PCSEIHI
OrthoDB EOG6Q2SQ2
BioCyc ECOL331111:GH7P-2964-MONOMER
Proteomes UP000001122
GO GO:0005737
GO:0004813
GO:0005524
GO:0000049
GO:0008270
GO:0006419
HAMAP MF_00036_B
InterPro IPR002318
IPR018162
IPR018165
IPR018164
IPR023033
IPR003156
IPR018163
IPR009000
IPR012947
Pfam PF02272
PF01411
PF07973
PRINTS PR00980
SMART SM00863
SUPFAM SSF101353
SSF50447
SSF55186
TIGRFAMs TIGR00344
PROSITE PS50860

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0004813

alanine-tRNA ligase activity

PMID:1549561[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002318
InterPro:IPR018162
InterPro:IPR018163
InterPro:IPR018164

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003156
InterPro:IPR018165

F

Seeded From UniProt

complete

enables

GO:0004812

aminoacyl-tRNA ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012947

F

Seeded From UniProt

complete

enables

GO:0004813

alanine-tRNA ligase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018162
InterPro:IPR018164
InterPro:IPR018165
InterPro:IPR023033

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012947
InterPro:IPR018162
InterPro:IPR018164
InterPro:IPR018165

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002318
InterPro:IPR018162

C

Seeded From UniProt

complete

involved_in

GO:0006419

alanyl-tRNA aminoacylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018162
InterPro:IPR018164
InterPro:IPR018165

P

Seeded From UniProt

complete

involved_in

GO:0043039

tRNA aminoacylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR012947

P

Seeded From UniProt

complete

enables

GO:0004813

alanine-tRNA ligase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:6.1.1.7

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000023192

C

Seeded From UniProt

complete

involved_in

GO:0006419

alanyl-tRNA aminoacylation

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000023192

P

Seeded From UniProt

complete

GO:0004813

alanine-tRNA ligase activity

PMID:1549561[1]

ECO:0000314

F

Figures 1,2.

complete
CACAO 3132

enables

GO:0004813

alanine-tRNA ligase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000023192

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000023192

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000023192

F

Seeded From UniProt

complete

enables

GO:0004812

aminoacyl-tRNA ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0030

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0000049

tRNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0820

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

enables

GO:0016874

ligase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0436

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0006412

translation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0648

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Miller, WT & Schimmel, P (1992) A retroviral-like metal binding motif in an aminoacyl-tRNA synthetase is important for tRNA recognition. Proc. Natl. Acad. Sci. U.S.A. 89 2032-5 PubMed GONUTS page