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DROME:SC6A4

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) SerT
Protein Name(s) Sodium-dependent serotonin transporter

5HT transporter 5HTT Cocaine-sensitive serotonin transporter dSERT1

External Links
UniProt P51905
EMBL U04809
AE013599
AY071023
U02296
RefSeq NP_001286839.1
NP_523846.2
UniGene Dm.5365
ProteinModelPortal P51905
SMR P51905
PRIDE P51905
EnsemblMetazoa FBtr0072362
GeneID 37895
KEGG dme:Dmel_CG4545
CTD 37895
FlyBase FBgn0010414
eggNOG COG0733
GeneTree ENSGT00760000118857
InParanoid P51905
KO K05037
OMA LRPERTI
OrthoDB EOG793B71
PhylomeDB P51905
GenomeRNAi 37895
NextBio 805922
PRO PR:P51905
Proteomes UP000000803
Bgee P51905
GO GO:0030424
GO:0043679
GO:0016021
GO:0005261
GO:0008504
GO:0005328
GO:0015222
GO:0098655
GO:0015844
GO:0006909
GO:0006837
GO:0051610
InterPro IPR000175
PANTHER PTHR11616
Pfam PF00209
PRINTS PR00176
PROSITE PS00610
PS00754
PS50267

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005261

cation channel activity

PMID:10404179[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005328

neurotransmitter:sodium symporter activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000175

F

Seeded From UniProt

complete

GO:0005886

plasma membrane

PMID:8302852[2]

ISS: Inferred from Sequence or Structural Similarity

HGNC:11050

C

Seeded From UniProt

complete

GO:0006810

transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

Seeded From UniProt

complete

GO:0006836

neurotransmitter transport

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000175

P

Seeded From UniProt

complete

GO:0006836

neurotransmitter transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0532

P

Seeded From UniProt

complete

GO:0006837

serotonin transport

PMID:10404179[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006909

phagocytosis

PMID:16336044[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008504

monoamine transmembrane transporter activity

PMID:11125028[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0015222

serotonin transmembrane transporter activity

PMID:10404179[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0015222

serotonin transmembrane transporter activity

PMID:16470720[5]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0015293

symporter activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0769

F

Seeded From UniProt

complete

GO:0015844

monoamine transport

PMID:11125028[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000175

C

Seeded From UniProt

complete

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

GO:0030424

axon

PMID:16470720[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0043679

axon terminus

PMID:16470720[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0051610

serotonin uptake

PMID:16470720[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0055085

transmembrane transport

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0769

P

Seeded From UniProt

complete

GO:0098655

cation transmembrane transport

PMID:10404179[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Petersen, CI & DeFelice, LJ (1999) Ionic interactions in the Drosophila serotonin transporter identify it as a serotonin channel. Nat. Neurosci. 2 605-10 PubMed GONUTS page
  2. Corey, JL et al. (1994) A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization. Proc. Natl. Acad. Sci. U.S.A. 91 1188-92 PubMed GONUTS page
  3. Stroschein-Stevenson, SL et al. (2006) Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol. 4 e4 PubMed GONUTS page
  4. 4.0 4.1 Pörzgen, P et al. (2001) The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines. Mol. Pharmacol. 59 83-95 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Park, SK et al. (2006) Cell-type-specific limitation on in vivo serotonin storage following ectopic expression of the Drosophila serotonin transporter, dSERT. J. Neurobiol. 66 452-62 PubMed GONUTS page