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DROME:SC6A4

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) SerT
Protein Name(s) Sodium-dependent serotonin transporter

5HT transporter 5HTT Cocaine-sensitive serotonin transporter dSERT1

External Links
UniProt P51905
EMBL U04809
AE013599
AY071023
U02296
RefSeq NP_001286839.1
NP_523846.2
UniGene Dm.5365
ProteinModelPortal P51905
SMR P51905
PRIDE P51905
EnsemblMetazoa FBtr0072362
GeneID 37895
KEGG dme:Dmel_CG4545
CTD 37895
FlyBase FBgn0010414
eggNOG COG0733
GeneTree ENSGT00760000118857
InParanoid P51905
KO K05037
OMA LRPERTI
OrthoDB EOG793B71
PhylomeDB P51905
GenomeRNAi 37895
NextBio 805922
PRO PR:P51905
Proteomes UP000000803
Bgee P51905
GO GO:0030424
GO:0043679
GO:0016021
GO:0005261
GO:0008504
GO:0005328
GO:0015222
GO:0098655
GO:0015844
GO:0006909
GO:0006837
GO:0051610
InterPro IPR000175
PANTHER PTHR11616
Pfam PF00209
PRINTS PR00176
PROSITE PS00610
PS00754
PS50267

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051610

serotonin uptake

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010414
MGI:MGI:96285
PANTHER:PTN002481010
RGD:3714
UniProtKB:P31645
WB:WBGene00003387

P

Seeded From UniProt

complete

enables

GO:0051378

serotonin binding

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002481010
UniProtKB:F1MLI6
UniProtKB:Q9XT49

F

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002481010
RGD:3714

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0035969
FB:FBgn0039915
MGI:MGI:1336891
MGI:MGI:1336892
MGI:MGI:95627
MGI:MGI:95760
PANTHER:PTN000177662
RGD:3714
RGD:3715
RGD:620533
RGD:621822
UniProtKB:P31645
UniProtKB:Q01959
UniProtKB:Q9Y345

C

Seeded From UniProt

complete

enables

GO:0005335

serotonin:sodium symporter activity

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0010414
PANTHER:PTN002481010
RGD:3714
UniProtKB:P31645
WB:WBGene00003387

F

Seeded From UniProt

complete

involved_in

GO:0051610

serotonin uptake

PMID:16470720[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030424

axon

PMID:16470720[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043679

axon terminus

PMID:16470720[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005335

serotonin:sodium symporter activity

PMID:16470720[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008504

monoamine transmembrane transporter activity

PMID:11125028[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0015844

monoamine transport

PMID:11125028[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005335

serotonin:sodium symporter activity

PMID:10404179[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006837

serotonin transport

PMID:10404179[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005261

cation channel activity

PMID:10404179[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:8302852[5]

ECO:0000250

sequence similarity evidence used in manual assertion

HGNC:11050

C

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005261

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0015293

P

Seeded From UniProt

complete

involved_in

GO:0098655

cation transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005261

P

Seeded From UniProt

complete

enables

GO:0005328

neurotransmitter:sodium symporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037272

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000175

C

Seeded From UniProt

complete

involved_in

GO:0006836

neurotransmitter transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0532

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0015293

symporter activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0769

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 Park, SK et al. (2006) Cell-type-specific limitation on in vivo serotonin storage following ectopic expression of the Drosophila serotonin transporter, dSERT. J. Neurobiol. 66 452-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 Pörzgen, P et al. (2001) The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines. Mol. Pharmacol. 59 83-95 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Petersen, CI & DeFelice, LJ (1999) Ionic interactions in the Drosophila serotonin transporter identify it as a serotonin channel. Nat. Neurosci. 2 605-10 PubMed GONUTS page
  5. ↑ Corey, JL et al. (1994) A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization. Proc. Natl. Acad. Sci. U.S.A. 91 1188-92 PubMed GONUTS page
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