It is now the 1st OPEN Period for CACAO Fall 2017! It will end on Sunday September 24, 2017 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:HUGIN

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Hug
Protein Name(s) Protein hugin

Hug-gamma Hug-peptide PK-2 Drm-PK-2 Myotrophin-2 Drm-MT2 MT-2 Pyrokinin-2

External Links
UniProt Q9VG55
EMBL AJ133105
AE014297
AY047528
RefSeq NP_524329.1
UniGene Dm.2437
BioGrid 66642
DIP DIP-17451N
IntAct Q9VG55
MINT MINT-1601192
STRING 7227.FBpp0082108
PaxDb Q9VG55
PRIDE Q9VG55
EnsemblMetazoa FBtr0082639
GeneID 41547
KEGG dme:Dmel_CG6371
CTD 15573
FlyBase FBgn0028374
eggNOG NOG295395
InParanoid Q9VG55
OMA SVPFKPR
OrthoDB EOG7HHWTV
PhylomeDB Q9VG55
GenomeRNAi 41547
NextBio 824337
Proteomes UP000000803
Bgee Q9VG55
GO GO:0005576
GO:0005615
GO:0008255
GO:0005179
GO:0016084
GO:0071855
GO:0005102
GO:0018990
GO:0030536
GO:0007218

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005102

receptor binding

PMID:12177421[1]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005179

hormone activity

PMID:11381038[2]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

GO:0005576

extracellular region

PMID:12171930[3]

NAS: Non-traceable Author Statement

C

Seeded From UniProt

complete

GO:0005615

extracellular space

PMID:16441518[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007218

neuropeptide signaling pathway

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0527

P

Seeded From UniProt

complete

GO:0007218

neuropeptide signaling pathway

PMID:12171930[3]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007218

neuropeptide signaling pathway

PMID:12951076[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007218

neuropeptide signaling pathway

PMID:16441518[4]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0008255

ecdysis-triggering hormone activity

PMID:12204246[6]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0028738

F

Seeded From UniProt

complete

GO:0016084

myostimulatory hormone activity

PMID:12204246[6]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0018990

ecdysis, chitin-based cuticle

PMID:12204246[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0018990

ecdysis, chitin-based cuticle

PMID:12204246[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0018990

ecdysis, chitin-based cuticle

PMID:12204246[6]

ISS: Inferred from Sequence or Structural Similarity

FB:FBgn0028738

P

Seeded From UniProt

complete

GO:0030536

larval feeding behavior

PMID:16122349[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071855

neuropeptide receptor binding

PMID:12951076[5]

IPI: Inferred from Physical Interaction

FB:FBgn0038139
FB:FBgn0038140

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Park, Y et al. (2002) Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc. Natl. Acad. Sci. U.S.A. 99 11423-8 PubMed GONUTS page
  2. Hewes, RS & Taghert, PH (2001) Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome. Genome Res. 11 1126-42 PubMed GONUTS page
  3. 3.0 3.1 Baggerman, G et al. (2002) Peptidomics of the larval Drosophila melanogaster central nervous system. J. Biol. Chem. 277 40368-74 PubMed GONUTS page
  4. 4.0 4.1 Wegener, C et al. (2006) Direct mass spectrometric peptide profiling and fragmentation of larval peptide hormone release sites in Drosophila melanogaster reveals tagma-specific peptide expression and differential processing. J. Neurochem. 96 1362-74 PubMed GONUTS page
  5. 5.0 5.1 Rosenkilde, C et al. (2003) Molecular cloning, functional expression, and gene silencing of two Drosophila receptors for the Drosophila neuropeptide pyrokinin-2. Biochem. Biophys. Res. Commun. 309 485-94 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 Meng, X et al. (2002) The Drosophila hugin gene codes for myostimulatory and ecdysis-modifying neuropeptides. Mech. Dev. 117 5-13 PubMed GONUTS page
  7. Melcher, C & Pankratz, MJ (2005) Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain. PLoS Biol. 3 e305 PubMed GONUTS page