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DROME:HUGIN

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Hug
Protein Name(s) Protein hugin

Hug-gamma Hug-peptide PK-2 Drm-PK-2 Myotrophin-2 Drm-MT2 MT-2 Pyrokinin-2

External Links
UniProt Q9VG55
EMBL AJ133105
AE014297
AY047528
RefSeq NP_524329.1
UniGene Dm.2437
BioGrid 66642
DIP DIP-17451N
IntAct Q9VG55
MINT MINT-1601192
STRING 7227.FBpp0082108
PaxDb Q9VG55
PRIDE Q9VG55
EnsemblMetazoa FBtr0082639
GeneID 41547
KEGG dme:Dmel_CG6371
CTD 15573
FlyBase FBgn0028374
eggNOG NOG295395
InParanoid Q9VG55
OMA SVPFKPR
OrthoDB EOG7HHWTV
PhylomeDB Q9VG55
GenomeRNAi 41547
NextBio 824337
Proteomes UP000000803
Bgee Q9VG55
GO GO:0005576
GO:0005615
GO:0008255
GO:0005179
GO:0016084
GO:0071855
GO:0005102
GO:0018990
GO:0030536
GO:0007218

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0018990

ecdysis, chitin-based cuticle

PMID:12204246[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:12171930[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:12171930[2]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:16441518[3]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16441518[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030536

larval feeding behavior

PMID:16122349[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

PMID:12951076[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0071855

neuropeptide receptor binding

PMID:12951076[5]

ECO:0000353

physical interaction evidence used in manual assertion

FB:FBgn0038139,FB:FBgn0038140

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:12177421[6]

ECO:0000250

sequence similarity evidence used in manual assertion

F

Seeded From UniProt

Missing: with/from

involved_in

GO:0018990

ecdysis, chitin-based cuticle

PMID:12204246[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008255

ecdysis-triggering hormone activity

PMID:12204246[1]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0028738

F

Seeded From UniProt

complete

enables

GO:0016084

myostimulatory hormone activity

PMID:12204246[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0018990

ecdysis, chitin-based cuticle

PMID:12204246[1]

ECO:0000250

sequence similarity evidence used in manual assertion

FB:FBgn0028738

P

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:11381038[7]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008255

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0016084

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0007218

neuropeptide signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0527

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Meng, X et al. (2002) The Drosophila hugin gene codes for myostimulatory and ecdysis-modifying neuropeptides. Mech. Dev. 117 5-13 PubMed GONUTS page
  2. 2.0 2.1 Baggerman, G et al. (2002) Peptidomics of the larval Drosophila melanogaster central nervous system. J. Biol. Chem. 277 40368-74 PubMed GONUTS page
  3. 3.0 3.1 Wegener, C et al. (2006) Direct mass spectrometric peptide profiling and fragmentation of larval peptide hormone release sites in Drosophila melanogaster reveals tagma-specific peptide expression and differential processing. J. Neurochem. 96 1362-74 PubMed GONUTS page
  4. Melcher, C & Pankratz, MJ (2005) Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain. PLoS Biol. 3 e305 PubMed GONUTS page
  5. 5.0 5.1 Rosenkilde, C et al. (2003) Molecular cloning, functional expression, and gene silencing of two Drosophila receptors for the Drosophila neuropeptide pyrokinin-2. Biochem. Biophys. Res. Commun. 309 485-94 PubMed GONUTS page
  6. Park, Y et al. (2002) Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc. Natl. Acad. Sci. U.S.A. 99 11423-8 PubMed GONUTS page
  7. Hewes, RS & Taghert, PH (2001) Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome. Genome Res. 11 1126-42 PubMed GONUTS page