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DROME:HSP27

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Hsp27
Protein Name(s) Heat shock protein 27
External Links
UniProt P02518
EMBL J01101
X03891
AE014296
AY118471
PIR A02921
D20647
RefSeq NP_001287001.1
NP_524000.1
UniGene Dm.2803
ProteinModelPortal P02518
SMR P02518
BioGrid 64473
DIP DIP-18749N
IntAct P02518
MINT MINT-749799
STRING 7227.FBpp0076182
PaxDb P02518
PRIDE P02518
EnsemblMetazoa FBtr0076454
GeneID 39078
KEGG dme:Dmel_CG4466
CTD 39078
FlyBase FBgn0001226
eggNOG NOG256133
GeneTree ENSGT00760000119238
InParanoid P02518
OMA SPYERSH
OrthoDB EOG7WHHBK
PhylomeDB P02518
Reactome REACT_247767
REACT_252605
GenomeRNAi 39078
NextBio 811805
Proteomes UP000000803
Bgee P02518
GO GO:0005737
GO:0005875
GO:0005634
GO:0042595
GO:0042742
GO:0050832
GO:0008340
GO:0007476
Gene3D 2.60.40.790
InterPro IPR002068
IPR001436
IPR008978
Pfam PF00011
PIRSF PIRSF036514
PRINTS PR00299
SUPFAM SSF49764
PROSITE PS01031

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0033554

cellular response to stress

PMID:9504816[1]

IDA: Inferred from Direct Assay

P

Go to figure 1

complete
CACAO 9182

GO:0005515

protein binding

PMID:9514881[2]

IPI: Inferred from Physical Interaction

FB:FBgn0010602

F

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:24292889[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:24292889[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005875

microtubule associated complex

PMID:18433294[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:21635778[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:15308776[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042595

behavioral response to starvation

PMID:18229455[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042742

defense response to bacterium

PMID:21076039[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050832

defense response to fungus

PMID:21076039[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Scheler, C et al. (1997) Identification and characterization of heat shock protein 27 protein species in human myocardial two-dimensional electrophoresis patterns. Electrophoresis 18 2823-31 PubMed GONUTS page
  2. Joanisse, DR et al. (1998) Cloning and developmental expression of a nuclear ubiquitin-conjugating enzyme (DmUbc9) that interacts with small heat shock proteins in Drosophila melanogaster. Biochem. Biophys. Res. Commun. 244 102-9 PubMed GONUTS page
  3. 3.0 3.1 Lee, SY et al. (2014) Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Cell. Mol. Life Sci. 71 2747-58 PubMed GONUTS page
  4. Hughes, JR et al. (2008) A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol. 6 e98 PubMed GONUTS page
  5. Carreira, VP et al. (2011) Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. BMC Dev. Biol. 11 32 PubMed GONUTS page
  6. Wang, HD et al. (2004) Multiple-stress analysis for isolation of Drosophila longevity genes. Proc. Natl. Acad. Sci. U.S.A. 101 12610-5 PubMed GONUTS page
  7. Hao, X et al. (2007) The Hsp27 gene is not required for Drosophila development but its activity is associated with starvation resistance. Cell Stress Chaperones 12 364-72 PubMed GONUTS page
  8. 8.0 8.1 Chen, J et al. (2010) Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. Proc. Natl. Acad. Sci. U.S.A. 107 20774-9 PubMed GONUTS page