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DROME:HSP27
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | Hsp27 | |
| Protein Name(s) | Heat shock protein 27 | |
| External Links | ||
| UniProt | P02518 | |
| EMBL | J01101 X03891 AE014296 AY118471 | |
| PIR | A02921 D20647 | |
| RefSeq | NP_001287001.1 NP_524000.1 | |
| UniGene | Dm.2803 | |
| ProteinModelPortal | P02518 | |
| SMR | P02518 | |
| BioGrid | 64473 | |
| DIP | DIP-18749N | |
| IntAct | P02518 | |
| MINT | MINT-749799 | |
| STRING | 7227.FBpp0076182 | |
| PaxDb | P02518 | |
| PRIDE | P02518 | |
| EnsemblMetazoa | FBtr0076454 | |
| GeneID | 39078 | |
| KEGG | dme:Dmel_CG4466 | |
| CTD | 39078 | |
| FlyBase | FBgn0001226 | |
| eggNOG | NOG256133 | |
| GeneTree | ENSGT00760000119238 | |
| InParanoid | P02518 | |
| OMA | SPYERSH | |
| OrthoDB | EOG7WHHBK | |
| PhylomeDB | P02518 | |
| Reactome | REACT_247767 REACT_252605 | |
| GenomeRNAi | 39078 | |
| NextBio | 811805 | |
| Proteomes | UP000000803 | |
| Bgee | P02518 | |
| GO | GO:0005737 GO:0005875 GO:0005634 GO:0042595 GO:0042742 GO:0050832 GO:0008340 GO:0007476 | |
| Gene3D | 2.60.40.790 | |
| InterPro | IPR002068 IPR001436 IPR008978 | |
| Pfam | PF00011 | |
| PIRSF | PIRSF036514 | |
| PRINTS | PR00299 | |
| SUPFAM | SSF49764 | |
| PROSITE | PS01031 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0033554 |
cellular response to stress |
ECO:0000314 |
P |
Go to figure 1 |
complete | |||||
|
involved_in |
GO:0061077 |
chaperone-mediated protein folding |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
P |
Seeded From UniProt |
Missing: with/from | |||
|
enables |
GO:0051082 |
unfolded protein binding |
ECO:0000255 |
match to sequence model evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0009408 |
response to heat |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042026 |
protein refolding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042742 |
defense response to bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042595 |
behavioral response to starvation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061077 |
chaperone-mediated protein folding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051082 |
unfolded protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008340 |
determination of adult lifespan |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Scheler, C et al. (1997) Identification and characterization of heat shock protein 27 protein species in human myocardial two-dimensional electrophoresis patterns. Electrophoresis 18 2823-31 PubMed GONUTS page
- ↑ 2.0 2.1 Li, ZW et al. (2009) The small heat shock protein (sHSP) genes in the silkworm, Bombyx mori, and comparative analysis with other insect sHSP genes. BMC Evol. Biol. 9 215 PubMed GONUTS page
- ↑ 3.0 3.1 Vos, MJ et al. (2016) Specific protein homeostatic functions of small heat-shock proteins increase lifespan. Aging Cell 15 217-26 PubMed GONUTS page
- ↑ 4.0 4.1 Lee, SY et al. (2014) Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10. Cell. Mol. Life Sci. 71 2747-58 PubMed GONUTS page
- ↑ 5.0 5.1 Chen, J et al. (2010) Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. Proc. Natl. Acad. Sci. U.S.A. 107 20774-9 PubMed GONUTS page
- ↑ Hao, X et al. (2007) The Hsp27 gene is not required for Drosophila development but its activity is associated with starvation resistance. Cell Stress Chaperones 12 364-72 PubMed GONUTS page
- ↑ 7.0 7.1 Morrow, G et al. (2006) Differences in the chaperone-like activities of the four main small heat shock proteins of Drosophila melanogaster. Cell Stress Chaperones 11 51-60 PubMed GONUTS page
- ↑ Wang, HD et al. (2004) Multiple-stress analysis for isolation of Drosophila longevity genes. Proc. Natl. Acad. Sci. U.S.A. 101 12610-5 PubMed GONUTS page
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