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DROME:BURS

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Burs (ECO:0000312 with FlyBase:FBgn0038901) (synonyms: burs-alpha)
Protein Name(s) Bursicon

Bursicon subunit alpha Cuticle-tanning hormone

External Links
UniProt Q9VD83
EMBL AY672905
AY672906
AJ862523
AM294583
AM294584
AM294585
AM294586
AM294587
AM294588
AM294589
AM294590
AM294591
AM294592
AM294593
AM294594
AE014297
RefSeq NP_650983.1
UniGene Dm.25481
ProteinModelPortal Q9VD83
SMR Q9VD83
PRIDE Q9VD83
EnsemblMetazoa FBtr0084131
GeneID 42560
KEGG dme:Dmel_CG13419
CTD 42560
FlyBase FBgn0038901
eggNOG NOG320464
InParanoid Q9VD83
OMA DEGPLNN
OrthoDB EOG79KPGZ
PhylomeDB Q9VD83
GenomeRNAi 42560
NextBio 829426
Proteomes UP000000803
Bgee Q9VD83
ExpressionAtlas Q9VD83
GO GO:0031395
GO:0005576
GO:0043195
GO:0005179
GO:0046982
GO:0007593
GO:0048067
InterPro IPR006207
IPR004133
Pfam PF03045
PROSITE PS01225

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005179

hormone activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

GO:0005179

hormone activity

PMID:15242619[1]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

GO:0005576

extracellular region

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

GO:0005576

extracellular region

PMID:15242619[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0007593

chitin-based cuticle sclerotization

PMID:15242619[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031395

bursicon neuropeptide hormone complex

PMID:15703293[2]

IPI: Inferred from Physical Interaction

FB:FBgn0264810

C

Seeded From UniProt

complete

GO:0031395

bursicon neuropeptide hormone complex

PMID:15811337[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0043195

terminal bouton

PMID:20807433[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0046982

protein heterodimerization activity

PMID:15811337[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VJS7

F

Seeded From UniProt

complete

GO:0048067

cuticle pigmentation

PMID:15242619[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

contributes_to

GO:0005184

neuropeptide hormone activity

PMID:15703293[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

contributes_to

GO:0005184

neuropeptide hormone activity

PMID:15811337[3]

IC: Inferred by Curator

GO:0031395

F

Seeded From UniProt

complete

contributes_to

GO:0071855

neuropeptide receptor binding

PMID:15703293[2]

IPI: Inferred from Physical Interaction

FB:FBgn0003255

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Dewey, EM et al. (2004) Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreading. Curr. Biol. 14 1208-13 PubMed GONUTS page
  2. 2.0 2.1 2.2 Luo, CW et al. (2005) Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2. Proc. Natl. Acad. Sci. U.S.A. 102 2820-5 PubMed GONUTS page
  3. 3.0 3.1 3.2 Mendive, FM et al. (2005) Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2. FEBS Lett. 579 2171-6 PubMed GONUTS page
  4. Loveall, BJ & Deitcher, DL (2010) The essential role of bursicon during Drosophila development. BMC Dev. Biol. 10 92 PubMed GONUTS page