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DICDI:PDPKA

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Species (Taxon ID) Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s) pdkA
Protein Name(s) Probable serine/threonine-protein kinase pdkA

3-phosphoinositide-dependent protein kinase A Pdk-class protein kinase A

External Links
UniProt Q54TW2
EMBL AAFI02000041
RefSeq XP_640699.1
ProteinModelPortal Q54TW2
STRING 44689.DDB0216243
PRIDE Q54TW2
EnsemblProtists DDB0216243
EAL66717
GeneID 8623085
KEGG ddi:DDB_G0281471
dictyBase DDB_G0281471
eggNOG COG0515
InParanoid Q54TW2
KO K06276
OMA KENKAHY
PhylomeDB Q54TW2
PRO PR:Q54TW2
Proteomes UP000002195
UP000002195
GO GO:0004676
GO:0005524
Gene3D 2.30.29.30
InterPro IPR011009
IPR011993
IPR001849
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
SMART SM00233
SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0098630

aggregation of unicellular organisms

PMID:20200230[1]

ECO:0000315

P

Figure 4B,C

complete
CACAO 11057

GO:0023014

signal transduction by protein phosphorylation

PMID:20200230[1]

ECO:0000315

P

Figure 4

complete
CACAO 11064

part_of

GO:0097708

intracellular vesicle

PMID:20075071[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:20075071[2]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0043327)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043327

chemotaxis to cAMP

PMID:20075071[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q54PK9

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030587

sorocarp development

PMID:20075071[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q54PK9

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:20075071[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032148

activation of protein kinase B activity

PMID:20075071[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P54644)|has_regulation_target:(UniProtKB:P28178)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032147

activation of protein kinase activity

PMID:20200230[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:P54644)|has_regulation_target:(UniProtKB:P28178)

Seeded From UniProt

complete

enables

GO:0004676

3-phosphoinositide-dependent protein kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z2A0

F

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003744
FB:FBgn0010379
MGI:MGI:97601
PANTHER:PTN000683254
PomBase:SPAC1B9.02c
PomBase:SPAC22E12.14c
PomBase:SPAPB18E9.02c
RGD:3395
RGD:3399
RGD:61925
RGD:620968
RGD:67383
SGD:S000000201
UniProtKB:O15530
UniProtKB:P31749
UniProtKB:Q15208
UniProtKB:Q9NRM7
UniProtKB:Q9Y2H1

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87986
PANTHER:PTN000683254
RGD:2081
RGD:3395
RGD:3399
RGD:3668
RGD:61925
SGD:S000001609
SGD:S000001861
SGD:S000002898
SGD:S000005460
UniProtKB:A0A1D5PUY5
UniProtKB:P31749
UniProtKB:P41743
UniProtKB:Q02156
UniProtKB:Q05513
UniProtKB:Q05655
WB:WBGene00000102
WB:WBGene00000103
WB:WBGene00004033
WB:WBGene00004034
WB:WBGene00004789
WB:WBGene00006599

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003091
FB:FBgn0003744
FB:FBgn0010379
FB:FBgn0260399
FB:FBgn0261854
MGI:MGI:104874
MGI:MGI:2182368
MGI:MGI:87986
MGI:MGI:894676
MGI:MGI:97595
MGI:MGI:97596
MGI:MGI:97599
MGI:MGI:97602
PANTHER:PTN000683254
PomBase:SPAC1B9.02c
PomBase:SPAC22E12.14c
PomBase:SPAC24B11.11c
PomBase:SPAC821.12
PomBase:SPAPB18E9.02c
PomBase:SPCC576.15c
RGD:2081
RGD:2082
RGD:3399
RGD:3668
RGD:620146
RGD:620968
RGD:62390
SGD:S000001248
SGD:S000001609
SGD:S000001861
SGD:S000002898
SGD:S000003324
SGD:S000005105
SGD:S000005460
SGD:S000006315
TAIR:locus:2088515
UniProtKB:O15530
UniProtKB:O95835
UniProtKB:P05771
UniProtKB:P17252
UniProtKB:P31749
UniProtKB:P31751
UniProtKB:P41743
UniProtKB:Q02156
UniProtKB:Q04759
UniProtKB:Q05513
UniProtKB:Q05655
UniProtKB:Q09013
UniProtKB:Q15208
UniProtKB:Q16512
UniProtKB:Q16513
UniProtKB:Q96GX5
UniProtKB:Q9NRM7
UniProtKB:Q9XF67
UniProtKB:Q9Y243
UniProtKB:Q9Y2H1
WB:WBGene00000102
WB:WBGene00000103
WB:WBGene00004034
WB:WBGene00004789
WB:WBGene00006599
dictyBase:DDB_G0268620

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039046

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Liao, XH et al. (2010) Chemotactic activation of Dictyostelium AGC-family kinases AKT and PKBR1 requires separate but coordinated functions of PDK1 and TORC2. J. Cell. Sci. 123 983-92 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Kamimura, Y & Devreotes, PN (2010) Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. J. Biol. Chem. 285 7938-46 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page