DICDI:MP2K1

Species (Taxon ID)	Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s)	mekA (ECO:0000312 with EMBL:EAL71926.1)
Protein Name(s)	Dual specificity mitogen-activated protein kinase kinase 1 (ECO:0000303 with PMID:12062087^[1], ECO:0000303 with PMID:9250676^[2]) MAP kinase kinase 1 (ECO:0000303 with PMID:12062087^[1], ECO:0000303 with PMID:9250676^[2]) MAPKK 1 (ECO:0000303 with PMID:12062087^[1], ECO:0000303 with PMID:9250676^[2]) ERK activator kinase 1 (ECO:0000303 with PMID:12062087^[1], ECO:0000303 with PMID:9250676^[2]) MAPK/ERK kinase 1 (ECO:0000303 with PMID:12062087^[1], ECO:0000303 with PMID:9250676^[2]) DdMEK1 (ECO:0000303 with PMID:12062087^[1], ECO:0000303 with PMID:9250676^[2]) MEK1 (ECO:0000303 with PMID:12062087^[1], ECO:0000303 with PMID:9250676^[2]) MAPK/ERK kinase A (ECO:0000312 with EMBL:EAL71926.1) MEKA (ECO:0000312 with EMBL:EAL71926.1)
External Links
UniProt	Q55CL6
EMBL	U87912 AAFI02000005
RefSeq	XP_646465.1
ProteinModelPortal	Q55CL6
STRING	44689.DDB0191164
PRIDE	Q55CL6
EnsemblProtists	DDB0191164
GeneID	8617426
KEGG	ddi:DDB_G0269152
dictyBase	DDB_G0269152
eggNOG	COG0515
InParanoid	Q55CL6
KO	K04368
OMA	LECAIGK
PhylomeDB	Q55CL6
Reactome	REACT_272501 REACT_279090 REACT_288867 REACT_295608 REACT_295914 REACT_352710 REACT_357093 REACT_361571 REACT_361578 REACT_362645
PRO	PR:Q55CL6
Proteomes	UP000002195 UP000002195
GO	GO:0031252 GO:0005737 GO:0005622 GO:0005634 GO:0005524 GO:0004708 GO:0046872 GO:0004672 GO:0004674 GO:0000187 GO:0031152 GO:0043327 GO:0000165 GO:0006468 GO:0030587
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0043130	ubiquitin binding	PMID:12062087^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q557I6	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:12062087^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_activity_of:(UniProtKB:P42525)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043327	chemotaxis to cAMP	PMID:12062087^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	PMID:12062087^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030587	sorocarp development	PMID:17659086^[3]	ECO:0007001	high throughput mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005938	cell cortex	PMID:12062087^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071320)	Seeded From UniProt	complete
colocalizes_with	GO:0005829	cytosol	PMID:12062087^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0071320)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12062087^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	PMID:12062087^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	happens_during:(GO:0071320)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	PMID:12062087^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C		Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261524 MGI:MGI:1346866 MGI:MGI:1346868 PANTHER:PTN000684494 PomBase:SPAC1D4.13 PomBase:SPBC409.07c RGD:1307040 RGD:1560043 RGD:61888 RGD:620666 RGD:70495 SGD:S000002318 SGD:S000003664 TAIR:locus:2017662 TAIR:locus:2120855 TAIR:locus:2164981 TAIR:locus:2170578 TAIR:locus:2206885 UniProtKB:A0A1D8PKE2 UniProtKB:O14733 UniProtKB:P36507 UniProtKB:P52564 UniProtKB:Q02750 UniProtKB:Q5BEU9 UniProtKB:Q9S7U9 WB:WBGene00003185 WB:WBGene00003186 WB:WBGene00004758 dictyBase:DDB_G0269152	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261524 MGI:MGI:1346866 MGI:MGI:1346868 MGI:MGI:1346870 PANTHER:PTN000684494 RGD:61890 RGD:70495 SGD:S000002318 SGD:S000003664 UniProtKB:P52564 UniProtKB:Q02750 WB:WBGene00003185 WB:WBGene00003368 WB:WBGene00004758 dictyBase:DDB_G0269152	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0031152	aggregation involved in sorocarp development	PMID:15473840^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0016020	membrane	PMID:15473840^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16962888^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005829	cytosol	PMID:15473840^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Sobko, A et al. (2002) Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Dev. Cell 2 745-56 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Ma, H et al. (1997) The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase. EMBO J. 16 4317-32 PubMed GONUTS page
↑ Sawai, S et al. (2007) High-throughput analysis of spatio-temporal dynamics in Dictyostelium. Genome Biol. 8 R144 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Manahan, CL et al. (2004) Chemoattractant signaling in dictyostelium discoideum. Annu. Rev. Cell Dev. Biol. 20 223-53 PubMed GONUTS page
↑ Willard, SS & Devreotes, PN (2006) Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum. Eur. J. Cell Biol. 85 897-904 PubMed GONUTS page

[PMID:12062087-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Sobko, A et al. (2002) Regulated SUMOylation and ubiquitination of DdMEK1 is required for proper chemotaxis. Dev. Cell 2 745-56 PubMed GONUTS page

[PMID:9250676-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Ma, H et al. (1997) The Dictyostelium MAP kinase kinase DdMEK1 regulates chemotaxis and is essential for chemoattractant-mediated activation of guanylyl cyclase. EMBO J. 16 4317-32 PubMed GONUTS page

[PMID:17659086-3] Sawai, S et al. (2007) High-throughput analysis of spatio-temporal dynamics in Dictyostelium. Genome Biol. 8 R144 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15473840-5] 5.0 ^5.1 ^5.2 Manahan, CL et al. (2004) Chemoattractant signaling in dictyostelium discoideum. Annu. Rev. Cell Dev. Biol. 20 223-53 PubMed GONUTS page

[PMID:16962888-6] Willard, SS & Devreotes, PN (2006) Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum. Eur. J. Cell Biol. 85 897-904 PubMed GONUTS page

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DICDI:MP2K1

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Annotations

Notes

References

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