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DICDI:IFKA

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Species (Taxon ID) Dictyostelium discoideum (Slime mold). (44689)
Gene Name(s) ifkA
Protein Name(s) Probable serine/threonine-protein kinase ifkA

Initiation factor kinase A

External Links
UniProt Q558U1
EMBL AAFI02000008
RefSeq XP_644975.1
ProteinModelPortal Q558U1
STRING 44689.DDB0185218
EnsemblProtists DDB0185218
GeneID 8618652
KEGG ddi:DDB_G0272837
dictyBase DDB_G0272837
eggNOG COG0515
InParanoid Q558U1
KO K16196
OMA EIEMIGK
PhylomeDB Q558U1
PRO PR:Q558U1
Proteomes UP000002195
UP000002195
GO GO:0005622
GO:0005524
GO:0004694
GO:0031152
GO:0019933
GO:0031589
GO:0048255
GO:0031158
GO:0006468
GO:0006417
GO:0006446
GO:0010998
GO:0016337
Gene3D 3.40.50.800
InterPro IPR004154
IPR024435
IPR011009
IPR000719
IPR017441
IPR008271
Pfam PF12745
PF00069
SUPFAM SSF52954
SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

acts_upstream_of_or_within

GO:0048255

mRNA stabilization

PMID:12697064[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031589

cell-substrate adhesion

PMID:17177855[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q550L8

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031158

negative regulation of aggregate size involved in sorocarp development

PMID:12697064[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031152

aggregation involved in sorocarp development

PMID:12697064[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019933

cAMP-mediated signaling

PMID:12697064[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0098609

cell-cell adhesion

PMID:17177855[2]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q550L8

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006468

protein phosphorylation

PMID:12697064[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006446

regulation of translational initiation

PMID:12697064[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15442

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006417

regulation of translation

PMID:12697064[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:12697064[1]

ECO:0000305

curator inference used in manual assertion

GO:0004694

F

Seeded From UniProt

complete

enables

GO:0004694

eukaryotic translation initiation factor 2alpha kinase activity

PMID:12697064[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004694

eukaryotic translation initiation factor 2alpha kinase activity

PMID:12697064[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P15442

F

Seeded From UniProt

complete

part_of

GO:0022626

cytosolic ribosome

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000867953
SGD:S000002691

C

Seeded From UniProt

complete

enables

GO:0004694

eukaryotic translation initiation factor 2alpha kinase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341830
MGI:MGI:1353427
PANTHER:PTN000867953
PomBase:SPBC36B7.09
RGD:70884
SGD:S000002691
UniProtKB:A0A0B4KHX7
UniProtKB:A0A1D8PQT9
UniProtKB:P19525
UniProtKB:Q9NZJ5
UniProtKB:Q9P2K8
dictyBase:DDB_G0272837

F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103075
MGI:MGI:1341830
MGI:MGI:1353448
MGI:MGI:1353449
PANTHER:PTN000113601
PomBase:SPBC36B7.09
SGD:S000002691
TAIR:locus:2024780
UniProtKB:P19525
UniProtKB:Q8IL26
WB:WBGene00006988
ZFIN:ZDB-GENE-050301-2
ZFIN:ZDB-GENE-080422-1

F

Seeded From UniProt

complete

involved_in

GO:0010998

regulation of translational initiation by eIF2 alpha phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004694

P

Seeded From UniProt

complete

involved_in

GO:0010998

regulation of translational initiation by eIF2 alpha phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004694

P

Seeded From UniProt

complete

involved_in

GO:0010998

regulation of translational initiation by eIF2 alpha phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004694

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Fang, R et al. (2003) IfkA, a presumptive eIF2 alpha kinase of Dictyostelium, is required for proper timing of aggregation and regulation of mound size. BMC Dev. Biol. 3 3 PubMed GONUTS page
  2. ↑ 2.0 2.1 Rai, M et al. (2006) Disruption of the ifkA and ifkB genes results in altered cell adhesion, morphological defects and a propensity to form pre-stalk O cells during development of Dictyostelium. Differentiation 74 583-95 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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