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DICDI:APRA
Contents
| Species (Taxon ID) | Dictyostelium discoideum (Slime mold). (44689) | |
| Gene Name(s) | aprA | |
| Protein Name(s) | Autocrine proliferation repressor protein A
PhoPQ-activated pathogenicity-related protein | |
| External Links | ||
| UniProt | Q5XM24 | |
| EMBL | AY750687 AAFI02000042 | |
| RefSeq | XP_640566.1 | |
| ProteinModelPortal | Q5XM24 | |
| STRING | 44689.DDB0231036 | |
| ESTHER | dicdi-apra | |
| PaxDb | Q5XM24 | |
| EnsemblProtists | EAL66593 | |
| GeneID | 8623176 | |
| KEGG | ddi:DDB_G0281663 | |
| dictyBase | DDB_G0281663 | |
| eggNOG | ENOG410IEY7 COG4287 | |
| InParanoid | Q5XM24 | |
| OMA | PKYIVNA | |
| PhylomeDB | Q5XM24 | |
| PRO | PR:Q5XM24 | |
| Proteomes | UP000002195 UP000002195 | |
| GO | GO:0005576 GO:0005622 GO:0043234 GO:0045499 GO:0008233 GO:0005102 GO:0007049 GO:0050919 GO:1903665 GO:0072659 GO:0031157 GO:0030435 | |
| Gene3D | 3.40.50.1820 | |
| InterPro | IPR029058 IPR009199 | |
| PANTHER | PTHR31497 | |
| Pfam | PF10142 | |
| PIRSF | PIRSF014728 | |
| SUPFAM | SSF53474 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0090630 |
activation of GTPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0072659 |
protein localization to plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_participant:(UniProtKB:Q54JL7) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050919 |
negative chemotaxis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
happens_during:(GO:0019954) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0045499 |
chemorepellent activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
happens_during:(GO:0019954) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031157 |
regulation of aggregate size involved in sorocarp development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0030435 |
sporulation resulting in formation of a cellular spore |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903665 |
negative regulation of asexual reproduction |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1903665 |
negative regulation of asexual reproduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008233 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Rijal, R et al. (2019) An endogenous chemorepellent directs cell movement by inhibiting pseudopods at one side of cells. Mol. Biol. Cell 30 242-255 PubMed GONUTS page
- ↑ Herlihy, SE et al. (2017) Functional similarities between the dictyostelium protein AprA and the human protein dipeptidyl-peptidase IV. Protein Sci. 26 578-585 PubMed GONUTS page
- ↑ Herlihy, SE et al. (2013) A Dictyostelium secreted factor requires a PTEN-like phosphatase to slow proliferation and induce chemorepulsion. PLoS ONE 8 e59365 PubMed GONUTS page
- ↑ 4.0 4.1 Phillips, JE & Gomer, RH (2012) A secreted protein is an endogenous chemorepellant in Dictyostelium discoideum. Proc. Natl. Acad. Sci. U.S.A. 109 10990-5 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Brock, DA & Gomer, RH (2005) A secreted factor represses cell proliferation in Dictyostelium. Development 132 4553-62 PubMed GONUTS page
- ↑ Phillips, JE et al. (2011) The putative bZIP transcription factor BzpN slows proliferation and functions in the regulation of cell density by autocrine signals in Dictyostelium. PLoS ONE 6 e21765 PubMed GONUTS page
- ↑ Bakthavatsalam, D et al. (2008) The secreted Dictyostelium protein CfaD is a chalone. J. Cell. Sci. 121 2473-80 PubMed GONUTS page
- ↑ Choe, JM et al. (2009) Dictyostelium cells bind a secreted autocrine factor that represses cell proliferation. BMC Biochem. 10 4 PubMed GONUTS page
