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DANRE:SETB2
Contents
| Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
| Gene Name(s) | setdb2 | |
| Protein Name(s) | Histone-lysine N-methyltransferase SETDB2
SET domain bifurcated 2 | |
| External Links | ||
| UniProt | Q06ZW3 | |
| EMBL | DQ358104 BC066376 | |
| RefSeq | NP_996941.1 | |
| UniGene | Dr.82071 | |
| ProteinModelPortal | Q06ZW3 | |
| PRIDE | Q06ZW3 | |
| GeneID | 335153 | |
| KEGG | dre:335153 | |
| CTD | 83852 | |
| ZFIN | ZDB-GENE-030131-7093 | |
| HOVERGEN | HBG097664 | |
| InParanoid | Q06ZW3 | |
| KO | K18494 | |
| PhylomeDB | Q06ZW3 | |
| NextBio | 20810694 | |
| PRO | PR:Q06ZW3 | |
| Proteomes | UP000000437 | |
| GO | GO:0005694 GO:0005634 GO:0003677 GO:0046974 GO:0008270 GO:0007059 GO:0007368 GO:0001947 GO:0051567 GO:0070986 GO:0007067 GO:0045892 | |
| InterPro | IPR016177 IPR001739 IPR007728 IPR001214 | |
| Pfam | PF01429 PF05033 PF00856 | |
| SMART | SM00317 | |
| SUPFAM | SSF54171 | |
| PROSITE | PS50867 PS50280 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:1904105 |
positive regulation of convergent extension involved in gastrulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Each section in Figure 1 shows observations of the effects of an injection of Setdb2 morpholino such as a wider and shorter notochord, broader neural plate, wider rhombomeres, and a slightly posteriorly located prechordal plate, which combined suggest that Setdb2 is involved in convergence and extension movements in gastrulation. |
complete | ||||
| GO:1904136 |
regulation of convergent extension involved in notochord morphogenesis |
ECO:0000315 |
P |
In figure 1 A and B, Setdb2 morpholino shows a wider and shorter notochord than the control embryo. Figure 1 J shows the length to width ratio of notochord cells for the control and setdb2 morpholino embryos. For the Setdb2 morpholino embryo, the length to width ratio is much smaller than that of the control. |
complete | |||||
| GO:1904130 |
regulation of convergent extension involved in neural plate elongation |
ECO:0000315 |
P |
In Figure 1 C,D,G neural plates are shown to be much wider in setdb2 morpholinos than in the control setdb2. |
complete | |||||
|
involved_in |
GO:0070986 |
left/right axis specification |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:1904133 |
regulation of convergent extension involved in rhombomere morphogenesis |
ECO:0000315 |
P |
In figure 1 E-G, the rhombomeres in Setdb2 morpholino groups are wider than in setdb2 control groups. |
complete | |||||
|
involved_in |
GO:0051567 |
histone H3-K9 methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046974 |
histone methyltransferase activity (H3-K9 specific) |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000278 |
mitotic cell cycle |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001947 |
heart looping |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060027 |
convergent extension involved in gastrulation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
ZFIN:ZDB-GENE-980526-389 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060027 |
convergent extension involved in gastrulation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-110201-1 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051567 |
histone H3-K9 methylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-110201-1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046974 |
histone methyltransferase activity (H3-K9 specific) |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-110201-1 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007368 |
determination of left/right symmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-110201-2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007368 |
determination of left/right symmetry |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
ZFIN:ZDB-MRPHLNO-110201-1 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034968 |
histone lysine methylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0018024 |
histone-lysine N-methyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Du, TT et al. (2014) Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1. Dev. Biol. 392 233-44 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Xu, PF et al. (2010) Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity. Proc. Natl. Acad. Sci. U.S.A. 107 2521-6 PubMed GONUTS page
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