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DANRE:SETB2

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) setdb2
Protein Name(s) Histone-lysine N-methyltransferase SETDB2

SET domain bifurcated 2

External Links
UniProt Q06ZW3
EMBL DQ358104
BC066376
RefSeq NP_996941.1
UniGene Dr.82071
ProteinModelPortal Q06ZW3
PRIDE Q06ZW3
GeneID 335153
KEGG dre:335153
CTD 83852
ZFIN ZDB-GENE-030131-7093
HOVERGEN HBG097664
InParanoid Q06ZW3
KO K18494
PhylomeDB Q06ZW3
NextBio 20810694
PRO PR:Q06ZW3
Proteomes UP000000437
GO GO:0005694
GO:0005634
GO:0003677
GO:0046974
GO:0008270
GO:0007059
GO:0007368
GO:0001947
GO:0051567
GO:0070986
GO:0007067
GO:0045892
InterPro IPR016177
IPR001739
IPR007728
IPR001214
Pfam PF01429
PF05033
PF00856
SMART SM00317
SUPFAM SSF54171
PROSITE PS50867
PS50280

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:1904103

regulation of convergent extension involved in gastrulation

PMID:24892953[1]

IMP: Inferred from Mutant Phenotype

P

Each section in Figure 1 shows observations of the effects of an injection of Setdb2 morpholino such as a wider and shorter notochord, broader neural plate, wider rhombomeres, and a slightly posteriorly located prechordal plate, which combined suggest that Setdb2 is involved in convergence and extension movements in gastrulation.

complete
CACAO 10547

GO:1904136

regulation of convergent extension involved in notochord morphogenesis

PMID:24892953[1]

IMP: Inferred from Mutant Phenotype

P

In figure 1 A and B, Setdb2 morpholino shows a wider and shorter notochord than the control embryo. Figure 1 J shows the length to width ratio of notochord cells for the control and setdb2 morpholino embryos. For the Setdb2 morpholino embryo, the length to width ratio is much smaller than that of the control.

complete
CACAO 10548

GO:1904130

regulation of convergent extension involved in neural plate elongation

PMID:24892953[1]

IMP: Inferred from Mutant Phenotype

P

In Figure 1 C,D,G neural plates are shown to be much wider in setdb2 morpholinos than in the control setdb2.

complete
CACAO 10711

GO:1904133

regulation of convergent extension involved in rhombomere morphogenesis

PMID:24892953[1]

IMP: Inferred from Mutant Phenotype

P

In figure 1 E-G, the rhombomeres in Setdb2 morpholino groups are wider than in setdb2 control groups.

complete
CACAO 10712

GO:0001947

heart looping

PMID:20133783[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001739
InterPro:IPR016177

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001739
InterPro:IPR007728

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q96T68

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005694

chromosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

GO:0005694

chromosome

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

GO:0007059

chromosome segregation

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q96T68

P

Seeded From UniProt

complete

GO:0007067

mitotic nuclear division

GO_REF:0000024

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:Q96T68

P

Seeded From UniProt

complete

GO:0007067

mitotic nuclear division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:20133783[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-110201-1

P

Seeded From UniProt

complete

GO:0007368

determination of left/right symmetry

PMID:20133783[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-110201-2

P

Seeded From UniProt

complete

GO:0008168

methyltransferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0489

F

Seeded From UniProt

complete

GO:0008270

zinc ion binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007728

F

Seeded From UniProt

complete

GO:0016568

chromatin modification

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007728

F

Seeded From UniProt

complete

GO:0018024

histone-lysine N-methyltransferase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.1.1.43

F

Seeded From UniProt

complete

GO:0032259

methylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0489

P

Seeded From UniProt

complete

GO:0034968

histone lysine methylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR007728

P

Seeded From UniProt

complete

GO:0045892

negative regulation of transcription, DNA-templated

PMID:20133783[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

GO:0046974

histone methyltransferase activity (H3-K9 specific)

PMID:20133783[2]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0046974

histone methyltransferase activity (H3-K9 specific)

PMID:20133783[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-110201-1

F

Seeded From UniProt

complete

GO:0051301

cell division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

GO:0051567

histone H3-K9 methylation

PMID:20133783[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0051567

histone H3-K9 methylation

PMID:20133783[2]

IMP: Inferred from Mutant Phenotype

ZFIN:ZDB-MRPHLNO-110201-1

P

Seeded From UniProt

complete

GO:0070986

left/right axis specification

PMID:20133783[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Du, TT et al. (2014) Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1. Dev. Biol. 392 233-44 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Xu, PF et al. (2010) Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity. Proc. Natl. Acad. Sci. U.S.A. 107 2521-6 PubMed GONUTS page