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DANRE:FGF8B
Contents
Species (Taxon ID) | Danio rerio (Zebrafish) (Brachydanio rerio). (7955) | |
Gene Name(s) | fgf8b (synonyms: fgf17 (ECO:0000312 with EMBL:BAC55316.1), fgf17a) | |
Protein Name(s) | Fibroblast growth factor 8b
FGF-8b Fibroblast growth factor 17a FGF-17a | |
External Links | ||
UniProt | Q805B2 | |
EMBL | AB100171 | |
RefSeq | NP_878276.1 | |
UniGene | Dr.20979 | |
ProteinModelPortal | Q805B2 | |
SMR | Q805B2 | |
Ensembl | ENSDART00000057885 | |
GeneID | 65089 | |
KEGG | dre:65089 | |
CTD | 65089 | |
ZFIN | ZDB-GENE-010122-1 | |
eggNOG | NOG327940 | |
GeneTree | ENSGT00730000110785 | |
HOGENOM | HOG000115986 | |
HOVERGEN | HBG005659 | |
InParanoid | Q805B2 | |
OMA | NFKHHVT | |
OrthoDB | EOG7DFXD5 | |
PhylomeDB | Q805B2 | |
TreeFam | TF331233 | |
Reactome | REACT_202022 REACT_204298 REACT_205098 REACT_211854 REACT_223377 REACT_224298 REACT_225510 REACT_226315 REACT_229653 REACT_232736 REACT_234868 REACT_239502 REACT_240635 REACT_243030 REACT_248177 REACT_256105 REACT_262090 REACT_262311 | |
NextBio | 20902016 | |
Proteomes | UP000000437 | |
Bgee | Q805B2 | |
GO | GO:0005576 GO:0005104 GO:0030154 GO:0008543 GO:0030917 GO:0007389 GO:0051781 | |
InterPro | IPR008996 IPR028249 IPR002209 IPR028142 | |
PANTHER | PTHR11486 PTHR11486:SF3 | |
PRINTS | PR00262 | |
SMART | SM00442 | |
SUPFAM | SSF50353 | |
PROSITE | PS00247 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0051155 |
positive regulation of striated muscle cell differentiation |
ECO:0000315 |
P |
Fig. 2A,B,D show expansion of undifferentiated lateral somite tissue at the expense of differentiated tissue in embryos wher FGF8 has been knocked down by morpholino oligomers. This suggests that FGF8 positively regulates differentiation when it is present. |
complete | |||||
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
P |
Fig. 3A shows downregulation of myoD and myogenin in embryos with FGF8 knocked out by morpholino oligomers. Fig. 3B,C show upregulation of myoD expression caused by implantation of FGF8 beads in wild type embryos and embryos with FGF8 knocked down by morpholio oligomers. |
complete | |||||
GO:0010629 |
negative regulation of gene expression |
ECO:0000315 |
P |
Fig. 3A shows upregulation of myf5 in embryos with FGF8 knocked out my morpholino oligomers. Fig. 4G shows upregulation of meox in embryos with FGF8 knocked out by morpholino oligomers. |
complete | |||||
GO:0014709 |
positive regulation of somitomeric trunk muscle development |
ECO:0000315 |
P |
Figs. 2,3,5 show lack of progression of somitic tissue development in morpholino oligomer knockdown embryos |
complete | |||||
involved_in |
GO:0030917 |
midbrain-hindbrain boundary development |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008543 |
fibroblast growth factor receptor signaling pathway |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007389 |
pattern specification process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005104 |
fibroblast growth factor receptor binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008083 |
growth factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007399 |
nervous system development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051781 |
positive regulation of cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Groves, JA et al. (2005) Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Development 132 4211-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Reifers, F et al. (2000) Overlapping and distinct functions provided by fgf17, a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs. Mech. Dev. 99 39-49 PubMed GONUTS page
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