DANRE:FGF8B

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Species (Taxon ID) Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s) fgf8b (synonyms: fgf17 (ECO:0000312 with EMBL:BAC55316.1), fgf17a)
Protein Name(s) Fibroblast growth factor 8b

FGF-8b Fibroblast growth factor 17a FGF-17a

External Links
UniProt Q805B2
EMBL AB100171
RefSeq NP_878276.1
UniGene Dr.20979
ProteinModelPortal Q805B2
SMR Q805B2
Ensembl ENSDART00000057885
GeneID 65089
KEGG dre:65089
CTD 65089
ZFIN ZDB-GENE-010122-1
eggNOG NOG327940
GeneTree ENSGT00730000110785
HOGENOM HOG000115986
HOVERGEN HBG005659
InParanoid Q805B2
OMA NFKHHVT
OrthoDB EOG7DFXD5
PhylomeDB Q805B2
TreeFam TF331233
Reactome REACT_202022
REACT_204298
REACT_205098
REACT_211854
REACT_223377
REACT_224298
REACT_225510
REACT_226315
REACT_229653
REACT_232736
REACT_234868
REACT_239502
REACT_240635
REACT_243030
REACT_248177
REACT_256105
REACT_262090
REACT_262311
NextBio 20902016
Proteomes UP000000437
Bgee Q805B2
GO GO:0005576
GO:0005104
GO:0030154
GO:0008543
GO:0030917
GO:0007389
GO:0051781
InterPro IPR008996
IPR028249
IPR002209
IPR028142
PANTHER PTHR11486
PTHR11486:SF3
PRINTS PR00262
SMART SM00442
SUPFAM SSF50353
PROSITE PS00247

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0051155

positive regulation of striated muscle cell differentiation

PMID:16120642[1]

IMP: Inferred from Mutant Phenotype

P

Fig. 2A,B,D show expansion of undifferentiated lateral somite tissue at the expense of differentiated tissue in embryos wher FGF8 has been knocked down by morpholino oligomers. This suggests that FGF8 positively regulates differentiation when it is present.

complete

GO:0010628

positive regulation of gene expression

PMID:16120642[1]

IMP: Inferred from Mutant Phenotype

P

Fig. 3A shows downregulation of myoD and myogenin in embryos with FGF8 knocked out by morpholino oligomers. Fig. 3B,C show upregulation of myoD expression caused by implantation of FGF8 beads in wild type embryos and embryos with FGF8 knocked down by morpholio oligomers.

complete

GO:0010629

negative regulation of gene expression

PMID:16120642[1]

IMP: Inferred from Mutant Phenotype

P

Fig. 3A shows upregulation of myf5 in embryos with FGF8 knocked out my morpholino oligomers. Fig. 4G shows upregulation of meox in embryos with FGF8 knocked out by morpholino oligomers.

complete

GO:0014709

positive regulation of somitomeric trunk muscle development

PMID:16120642[1]

IMP: Inferred from Mutant Phenotype

P

Figs. 2,3,5 show lack of progression of somitic tissue development in morpholino oligomer knockdown embryos

complete

GO:0005104

fibroblast growth factor receptor binding

PMID:11091072[2]

NAS: Non-traceable Author Statement

F

complete

GO:0005576

extracellular region

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0964

C

complete

GO:0005576

extracellular region

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0243

C

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0007389

pattern specification process

PMID:11091072[2]

NAS: Non-traceable Author Statement

P

complete

GO:0007399

nervous system development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0524

P

complete

GO:0005102

receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028142

F

Seeded From UniProt

complete

GO:0008083

growth factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002348

F

complete

GO:0005104

fibroblast growth factor receptor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028249

F

Seeded From UniProt

complete

GO:0005104

fibroblast growth factor receptor binding

PMID:11091072[2]

NAS: Non-traceable Author Statement

F

Seeded From UniProt

complete

GO:0008083

growth factor activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0339

F

complete

GO:0005576

extracellular region

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028249

C

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

PMID:11091072[2]

NAS: Non-traceable Author Statement

P

complete

GO:0005576

extracellular region

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0221

P

complete

GO:0005576

extracellular region

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

GO:0030917

midbrain-hindbrain boundary development

PMID:11091072[2]

NAS: Non-traceable Author Statement

P

complete

GO:0051781

positive regulation of cell division

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0497

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007389

pattern specification process

PMID:11091072[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0007399

nervous system development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

GO:0008083

growth factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002209

F

Seeded From UniProt

complete

GO:0008083

growth factor activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR028249

P

Seeded From UniProt

complete

GO:0008543

fibroblast growth factor receptor signaling pathway

PMID:11091072[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0030917

midbrain-hindbrain boundary development

PMID:11091072[2]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0051781

positive regulation of cell division

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0497

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Groves, JA et al. (2005) Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Development 132 4211-22 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Reifers, F et al. (2000) Overlapping and distinct functions provided by fgf17, a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs. Mech. Dev. 99 39-49 PubMed GONUTS page