DANRE:FGF8B

Species (Taxon ID)	Danio rerio (Zebrafish) (Brachydanio rerio). (7955)
Gene Name(s)	fgf8b (synonyms: fgf17 (ECO:0000312 with EMBL:BAC55316.1), fgf17a)
Protein Name(s)	Fibroblast growth factor 8b FGF-8b Fibroblast growth factor 17a FGF-17a
External Links
UniProt	Q805B2
EMBL	AB100171
RefSeq	NP_878276.1
UniGene	Dr.20979
ProteinModelPortal	Q805B2
SMR	Q805B2
Ensembl	ENSDART00000057885
GeneID	65089
KEGG	dre:65089
CTD	65089
ZFIN	ZDB-GENE-010122-1
eggNOG	NOG327940
GeneTree	ENSGT00730000110785
HOGENOM	HOG000115986
HOVERGEN	HBG005659
InParanoid	Q805B2
OMA	NFKHHVT
OrthoDB	EOG7DFXD5
PhylomeDB	Q805B2
TreeFam	TF331233
Reactome	REACT_202022 REACT_204298 REACT_205098 REACT_211854 REACT_223377 REACT_224298 REACT_225510 REACT_226315 REACT_229653 REACT_232736 REACT_234868 REACT_239502 REACT_240635 REACT_243030 REACT_248177 REACT_256105 REACT_262090 REACT_262311
NextBio	20902016
Proteomes	UP000000437
Bgee	Q805B2
GO	GO:0005576 GO:0005104 GO:0030154 GO:0008543 GO:0030917 GO:0007389 GO:0051781
InterPro	IPR008996 IPR028249 IPR002209 IPR028142
PANTHER	PTHR11486 PTHR11486:SF3
PRINTS	PR00262
SMART	SM00442
SUPFAM	SSF50353
PROSITE	PS00247

Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0051155	positive regulation of striated muscle cell differentiation	PMID:16120642^[1]	IMP: Inferred from Mutant Phenotype		P	Fig. 2A,B,D show expansion of undifferentiated lateral somite tissue at the expense of differentiated tissue in embryos wher FGF8 has been knocked down by morpholino oligomers. This suggests that FGF8 positively regulates differentiation when it is present.	complete
	GO:0010628	positive regulation of gene expression	PMID:16120642^[1]	IMP: Inferred from Mutant Phenotype		P	Fig. 3A shows downregulation of myoD and myogenin in embryos with FGF8 knocked out by morpholino oligomers. Fig. 3B,C show upregulation of myoD expression caused by implantation of FGF8 beads in wild type embryos and embryos with FGF8 knocked down by morpholio oligomers.	complete
	GO:0010629	negative regulation of gene expression	PMID:16120642^[1]	IMP: Inferred from Mutant Phenotype		P	Fig. 3A shows upregulation of myf5 in embryos with FGF8 knocked out my morpholino oligomers. Fig. 4G shows upregulation of meox in embryos with FGF8 knocked out by morpholino oligomers.	complete
	GO:0014709	positive regulation of somitomeric trunk muscle development	PMID:16120642^[1]	IMP: Inferred from Mutant Phenotype		P	Figs. 2,3,5 show lack of progression of somitic tissue development in morpholino oligomer knockdown embryos	complete
	GO:0005104	fibroblast growth factor receptor binding	PMID:11091072^[2]	NAS: Non-traceable Author Statement		F		complete
	GO:0005576	extracellular region	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0964	C		complete
	GO:0005576	extracellular region	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0243	C		complete
	GO:0007275	multicellular organismal development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0217	P		complete
	GO:0007389	pattern specification process	PMID:11091072^[2]	NAS: Non-traceable Author Statement		P		complete
	GO:0007399	nervous system development	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0524	P		complete
	GO:0005102	receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR028142	F	Seeded From UniProt	complete
	GO:0008083	growth factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002348	F		complete
	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR028249	F	Seeded From UniProt	complete
	GO:0005104	fibroblast growth factor receptor binding	PMID:11091072^[2]	NAS: Non-traceable Author Statement		F	Seeded From UniProt	complete
	GO:0008083	growth factor activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0339	F		complete
	GO:0005576	extracellular region	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR028249	C	Seeded From UniProt	complete
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:11091072^[2]	NAS: Non-traceable Author Statement		P		complete
	GO:0005576	extracellular region	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	Seeded From UniProt	complete
	GO:0030154	cell differentiation	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0221	P		complete
	GO:0005576	extracellular region	GO_REF:0000039	IEA: Inferred from Electronic Annotation	UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
	GO:0030917	midbrain-hindbrain boundary development	PMID:11091072^[2]	NAS: Non-traceable Author Statement		P		complete
	GO:0051781	positive regulation of cell division	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0497	P		complete
	GO:0007275	multicellular organismal development	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
	GO:0007389	pattern specification process	PMID:11091072^[2]	NAS: Non-traceable Author Statement		P	Seeded From UniProt	complete
	GO:0007399	nervous system development	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
	GO:0008083	growth factor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002209	F	Seeded From UniProt	complete
	GO:0008083	growth factor activity	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR028249	P	Seeded From UniProt	complete
	GO:0008543	fibroblast growth factor receptor signaling pathway	PMID:11091072^[2]	NAS: Non-traceable Author Statement		P	Seeded From UniProt	complete
	GO:0030154	cell differentiation	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
	GO:0030917	midbrain-hindbrain boundary development	PMID:11091072^[2]	NAS: Non-traceable Author Statement		P	Seeded From UniProt	complete
	GO:0051781	positive regulation of cell division	GO_REF:0000037	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0497	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Groves, JA et al. (2005) Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Development 132 4211-22 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Reifers, F et al. (2000) Overlapping and distinct functions provided by fgf17, a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs. Mech. Dev. 99 39-49 PubMed GONUTS page

[PMID:16120642-1] 1.0 ^1.1 ^1.2 ^1.3 Groves, JA et al. (2005) Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Development 132 4211-22 PubMed GONUTS page

[PMID:11091072-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Reifers, F et al. (2000) Overlapping and distinct functions provided by fgf17, a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs. Mech. Dev. 99 39-49 PubMed GONUTS page

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[2]

DANRE:FGF8B

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