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Category:Team Team

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableBACAN:LEFAndrew.james, Team Team2012-11-17 15:48:13 CSTGO:0006508 proteolysis (P)PMID:23152930ECO:0000314 direct assay evidence used in manual assertion

Figure 2 and 3

challenge
acceptableECOLI:MCP1Courtney.kast, Team Team2012-11-15 16:03:46 CSTGO:0048870 cell motility (P)PMID:21803986ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 and 5 show motility through chemotaxis

challenge
acceptableDROME:CHDMAndrew.james, Team Team2012-11-15 12:32:56 CSTGO:0051312 chromosome decondensation (P)PMID:22912596ECO:0000315 mutant phenotype evidence used in manual assertion

Fig.5 shows that dMi-2 is required for full decondensation of heat-shock loci.

challenge
acceptableDROME:CHDMAndrew.james, Team Team2012-11-15 12:29:09 CSTGO:0140658 ATP-dependent chromatin remodeler activity (F)PMID:22912596ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 shows MI-2's involvement with chromatin structure

GO term changed per Ticket-3833 ~~~~

challenge
requireschangesDROME:SYMMCourtney.kast, Team Team2012-11-15 10:03:29 CSTGO:0007629 flight behavior (P)PMID:22448145ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2: mutants missing Aats-mets are unable to fly.

challenge
requireschangesDROME:SYMMCourtney.kast, Team Team2012-11-15 09:49:07 CSTGO:0044429 mitochondrial part (C)PMID:22448145ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3C-E: Mitochondria are clearly aberrant; they are larger than normal

challenge
requireschangesDROME:SYMMCourtney.kast, Team Team2012-11-15 09:47:57 CSTGO:0045494 photoreceptor cell maintenance (P)PMID:22448145ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2: Loss of Aats-met in the Eye Results in Retinal Degeneration

challenge
requireschangesDROME:SYMMCourtney.kast, Team Team2012-11-15 09:47:57 CSTGO:0008340 determination of adult lifespan (P)PMID:22448145ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2J, 3A, 3C: Loss of Aats-met Results in Reduced Lifespan

challenge
acceptableECOLI:MCP1Courtney.kast, Team Team2012-11-15 07:41:53 CSTGO:0007165 signal transduction (P)PMID:21803986ECO:0000315 mutant phenotype evidence used in manual assertion

Fig. 4 shows examples of tsr control cable mutants signaling defects. See also Fig 7.

challenge
acceptableECOLI:MCP1Courtney.kast, Team Team2012-11-15 07:41:53 CSTGO:0006935 chemotaxis (P)PMID:21803986ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2: shows mutant chemotaxis phenotypes

challenge
unacceptableECOLI:MCP1Courtney.kast, Team Team2012-11-15 07:41:53 CSTGO:0060286 flagellar cell motility (P)PMID:21803986ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 3

challenge
unacceptableHUMAN:LIN41Courtney.kast, Team Team2012-11-11 19:00:14 CSTGO:0006417 regulation of translation (P)PMID:23125361ECO:0000314 direct assay evidence used in manual assertion


Figure 2 shows how TRIM71 is a repressor of mRNA function. Specifically 2f shows regulations through use of plasmids. In this instance, this is regulation through repression.

challenge
acceptableHUMAN:LIN41Courtney.kast, Team Team2012-11-11 19:00:14 CSTGO:0017148 negative regulation of translation (P)PMID:23125361ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows how TRIM71 is a repressor of mRNA function. Specifically 2f and 2g shows repression through use of plasmids. Negative regulation is brought upon by repression of mRNAs

challenge
unacceptableHUMAN:LIN41Courtney.kast, Team Team2012-11-11 19:00:14 CSTGO:0061157 mRNA destabilization (P)PMID:23125361ECO:0000314 direct assay evidence used in manual assertion

Figure 2 data shows a decrease in mRNA abundance due to accelerated mRNA decay. Specifically 2c shows the degradation of mRNA.

challenge
acceptableHUMAN:LIN41Courtney.kast, Team Team2012-11-11 19:00:14 CSTGO:0061158 3'-UTR-mediated mRNA destabilization (P)PMID:23125361ECO:0000314 direct assay evidence used in manual assertion

Figure 2 collectively shows the data indicates that TRIM71 associates with 3′UTRs of many mRNAs and this decreases the number of mRNAs due to accelerated mRNA decay. Specifically 2c.

challenge
acceptableHUMAN:LIN41Courtney.kast, Team Team2012-11-11 18:47:02 CSTGO:0030371 translation repressor activity (F)PMID:23125361ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows how TRIM71 is a repressor of mRNA function. Specifically 2f and 2g shows repression through use of plasmids

challenge
unacceptableHUMAN:SDF1Colin.taylor, Team Team2012-11-04 15:19:07 CSTGO:0042148 strand invasion (P)PMID:2684108ECO:0000314 direct assay evidence used in manual assertion

Figure 6 shows that from the data collected, CXCL12 invades tumor cells and will cause the formation of CXCL8 products.

challenge
unacceptableHUMAN:IL8Colin.taylor, Team Team2012-11-04 15:02:43 CSTGO:0001525 angiogenesis (P)PMID:2684108ECO:0000314 direct assay evidence used in manual assertion

Figure 5 show that CXCL8 effect that blood vessel formation and that different concentration have different effects on angiogenesis.

challenge
unacceptableHUMAN:SDF1Colin.taylor, Team Team2012-11-04 14:55:44 CSTGO:0008283 cell proliferation (P)PMID:2684108ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows that the different concentration of CXCL12 effect the overall proliferation of the cell.

challenge
unacceptableHUMAN:IL8Colin.taylor, Team Team2012-11-04 14:53:19 CSTGO:0008283 cell proliferation (P)PMID:2684108ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows that with different concentration of CXCL8 effects the overall cell proliferation.

challenge
requireschangesECOLI:PBP2Paige.stump, Team Team2012-09-23 15:42:07 CDTGO:0009252 peptidoglycan biosynthetic process (P)PMID:2681889ECO:0000315 mutant phenotype evidence used in manual assertion

figure 7 shows penicilin binding protein 2 untethers the incorporation of peptidoglycan in the cell walls

challenge
acceptableMOUSE:GRHL2Andrew.james, Team Team2012-09-23 15:05:10 CDTGO:0045893 positive regulation of transcription, DNA-dependent (P)PMID:22955271ECO:0000315 mutant phenotype evidence used in manual assertion

Fig. 4 shows Down-regulation of Grhl2 affects expression of its target genes.

challenge
unacceptableECOLX:SULAPaige.stump, Team Team2012-09-23 14:21:26 CDTGO:0009273 peptidoglycan-based cell wall biogenesis (P)PMID:3343033ECO:0000315 mutant phenotype evidence used in manual assertion

figure 5 shows clustered peptidoglycan insertion in teh absence of ftsZ

challenge
unacceptableHUMAN:MYD88Paige.stump, Team Team2012-09-23 12:28:37 CDTGO:0002224 toll-like receptor signaling pathway (P)PMID:3409161ECO:0000314 direct assay evidence used in manual assertion

figure 2 shows cxcl2 activity relate to activator only

challenge
requireschangesMOUSE:MO2R1Colin.taylor, Team Team2012-09-22 22:49:09 CDTGO:0042098 T cell proliferation (P)PMID:2990942ECO:0000315 mutant phenotype evidence used in manual assertion

In figure 3 one can see that in mice that have CD200R1−/− mice T-cell proliferation has increased

challenge
requireschangesMOUSE:SESN2Colin.taylor, Team Team2012-09-21 18:28:18 CDTGO:0000723 telomere maintenance (P)PMID:22958918ECO:0000021 physical interaction evidence

From the graphical abstract one can see that SESN2 would be used as an activating and maintainer of AMPK. This is also seen in figure one where the concentration of SESN2 effects the activation of AMPK

challenge
requireschangesMOUSE:SESN2Colin.taylor, Team Team2012-09-21 18:25:06 CDTGO:0010255 glucose mediated signaling pathway (P)PMID:22958918ECO:0000314 direct assay evidence used in manual assertion

Figure 1A and 1B show that a deficiency in SESN2 had a great effect on the activation and production of Glucose.

challenge
requireschangesHUMAN:SOX2Colin.taylor, Team Team2012-09-20 21:19:53 CDTGO:0045289 luciferin monooxygenase activity (F)PMID:22265740ECO:0000314 direct assay evidence used in manual assertion

In figure 6 B Co-transfection of the SOX2 overexpression vector with the TRKC-LUC Site A + B reporter resulted in a 2.0-fold increase in luciferase activity compared to cells transfected with the empty overexpression vector

challenge
unacceptableI68A4:C7RWE8Colin.taylor, Team Team2012-09-19 17:14:06 CDTGO:0003746 translation elongation factor activity (F)PMID:22261818ECO:0000314 direct assay evidence used in manual assertion

Table 3 shows that the activation of PBI-F2 protein creates length variation of the sequence

challenge
requireschangesXENLA:SHRM3Courtney.kast, Team Team2012-09-19 14:51:21 CDTGO:0003382 epithelial cell morphogenesis (P)PMID:20332151ECO:0000314 direct assay evidence used in manual assertion

Fig 6D depicts Shroom3 expression in the epidermis

challenge
requireschangesXENLA:SHRM3Courtney.kast, Team Team2012-09-19 14:39:32 CDTGO:0048546 digestive tract morphogenesis (P)PMID:20332151ECO:0000314 direct assay evidence used in manual assertion

Fig 1 depicts how Shroom3 is is essential for morphogenesis of the developing gut

challenge
requireschangesSYNE7:KATGCourtney.kast, Team Team2012-09-19 14:03:44 CDTGO:0004096 catalase activity (F)PMID:8645214ECO:0000314 direct assay evidence used in manual assertion

Fig 1 clearly shows the purified catalase enzyme

challenge
unacceptableECOLI:MCP1Courtney.kast, Team Team2012-09-19 13:27:29 CDTGO:0008984 protein-glutamate methylesterase activity (F)PMID:21803986ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 1 shows methylation sites indicating glutamine residues that must be deamidated to glutamates

challenge
unacceptableHUMAN:KDM1ACourtney.kast, Team Team2012-09-19 13:15:24 CDTGO:0070076 histone lysine demethylation (P)PMID:18440794ECO:0000315 mutant phenotype evidence used in manual assertion

Table 1 shows the demethylation developmental expression patterns

challenge
acceptableENTFL:Q04114Courtney.kast, Team Team2012-09-19 09:15:47 CDTGO:0017053 transcriptional repressor complex (C)PMID:22544272ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 2 shows the effects of mutations on the ability of PrgX to repress prgQ transcription

challenge


CACAO assessment

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Pages in category "Team Team"

The following 4 pages are in this category, out of 4 total.


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