Category:Team Espresso my genes

Figure 1 shows how DotA promotes biofilm formation

Figure 3 shows that EnhC binds to murein transglycosylase (sltL), which degrades peptidoglycan, and inhibits it, causing L. pneumophila to be able to survive in macrophages

FIGURE 5.

C-terminal fragments of SidM localize to LCVs. A, confocal laser scanning micrographs of calnexin-GFP-labeled D. discoideum Ax3 (green), infected at an m.o.i. of 50 for 1 h with L. pneumophila labeled with a serogroup 1-specific antibody (red) and ...

Figure 1A. The protein also displayed weaker interactions with PtdIns(3,4)P2. The major PtdIns(4)P interactor was identified by mass spectrometry as the 73-kDa protein SidM, a known Icm/Dot substrate previously characterized as a Rab1 GEF.

Figure1. The homology of CIDE-A, CIDE-B and FSP27 with DFF45 was restricted to an N-terminal region designated here as CIDE-N domain which showed 39, 29 and 38% amino acid identity respectively with DFF45. Another region of CIDE-A and CIDE-B, termed CIDE-C domain, located in their C-termini shared amino acid homology (54 and 53% identity, respectively) with FSP27 but not with DFF45

Figure 1. The human homolog of CIDE-A. Analysis of the nucleotide sequence of both human and mouse CIDE-A cDNAs revealed two potential in-frame translation initi- ation sites separated by 51 nucleotides. These two potential initiation codons produce a protein of 217 amino acids (designated CIDE-A*) and a protein identical to CIDE-A* but lacking its 17 most N-terminal amino acids (designated CIDE-A)

Fig. 1. Major IPs of L. pneumophila. A crude extract of L. pneumophila grown on agar medium containing 59Fe was subjected to ND-PAGE, and the radiolabeled proteins were visualized by autoradiography (right). A crude extract of E. coli obtained under the same conditions was included as a control (left).

Fig 6

As shown in Figure 7(B), the NACHT domain of CLAN is sufficient to inhibit Nod2-induced IL-1β secretion, while the NB-ARC domain of Apaf-1 had no inhibitory effects when co-expressed with Nod2

Figure 1. study was the identification of podocyte exosome proteins based on urine immunoabsorption using podocyte-specific CR1-immunocoated beads followed by proteomic analysis using LC MS/MS techniques.

IPI: Inferred from Physical Interaction - UniProtKB:O14727

InterPro:IPR001029 - IEA: Inferred from Electronic Annotation

InterPro:IPR008104 - IEA: Inferred from Electronic Annotation

Specific adaptors regulate the activation of initiator caspases; for example, FADD and Apaf-1 engage caspases 8 and 9, respectively. The adaptors ASC, Ipaf and RIP2 have each been proposed to regulate caspase-1 (also called interleukin (IL)-1 converting enzyme), which is activated within the 'inflammasome', a complex comprising several adaptors.

The neuronal apoptosis inhibitory protein (NAIP) was identified as a candidate gene for the inherited neurodegenerative disorder spinal muscular atrophy.

pathogenesis (IEA)

Figure 2. (NAIP)