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Category:Team DC2

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableMOUSE:ANXA1Dayna.love, Team DC22012-11-15 09:53:53 CSTGO:0014839 myoblast migration involved in skeletal muscle regeneration (P)PMID:23144744ECO:0000314 direct assay evidence used in manual assertion

Fig. 3 shows ANXA1-derived Peptide Ac2-26 Induces C2C12 Cell Migration

challenge
updatedbyinstructorHUMAN:COM1Cam.change, Team DC22012-11-15 09:08:47 CSTGO:0006289 nucleotide-excision repair (P)PMID:23144634ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1. CtIP depletion sensitizes cells to ICL inducing agents.

challenge
updatedbyinstructorMOUSE:SQSTMCam.change, Team DC22012-11-15 08:38:04 CSTGO:0044130 negative regulation of growth of symbiont in host (P)PMID:23148214ECO:0000315 mutant phenotype evidence used in manual assertion

FIGURE 4, 5

challenge
acceptableHUMAN:WFDC2Dayna.love, Team DC22012-11-15 08:32:20 CSTGO:0019828 aspartic-type endopeptidase inhibitor activity (F)PMID:23139753ECO:0000314 direct assay evidence used in manual assertion

Figure 4. A)Percentage inhibition of various proteases like: trypsin, chymottrypsin, PSA, proteinase K, pepsin and papain by HE-4. Graph shows a direct relationship with aspartic proteases.

challenge
acceptableHUMAN:WFDC2Dayna.love, Team DC22012-11-15 08:28:33 CSTGO:0004867 serine-type endopeptidase inhibitor activity (F)PMID:23139753ECO:0000314 direct assay evidence used in manual assertion

Figure 4. A)Percentage inhibition of various proteases like: trypsin, chymottrypsin, PSA, proteinase K, pepsin and papain by HE-4. Graph shows a direct relationship with serine proteases.

challenge
updatedbyinstructorBPT4:NEEDLDanielle.ocallaghan, Team DC22012-11-15 08:12:37 CSTGO:0098025 virus tail, baseplate (C)PMID:3157805ECO:0000314 direct assay evidence used in manual assertion

The tail-lysozyme was unambiguously identified as gp5 when the position of the lysozyme was compared with that of gp5 of tube-baseplates from 5ts1/23amH11/eL1ainfected Escherichia coli cells by two-dimensional gel electrophoresis. see figure 4

challenge
acceptableBPT4:RLIGDanielle.ocallaghan, Team DC22012-11-15 08:00:25 CSTGO:0098004 virus tail fiber assembly (P)PMID:333436ECO:0000315 mutant phenotype evidence used in manual assertion

RNA ligase promotes tail fiber attachment. The product of gene 63 is known to promote attachment of tail fibers to the phage baseplate in the terminal step of T4 phage assembly. See figure 1

challenge
unacceptableRAT:SOSD1Dayna.love, Team DC22012-11-03 21:49:03 CDTGO:0030513 positive regulation of BMP signaling pathway (P)PMID:17460719ECO:0000314 direct assay evidence used in manual assertion

Fig 1. shows a statistically significant improvement in the incidence of bony union when administration of the

Ad.BMP-2 was delayed

challenge
updatedbyinstructorBPT4:RLIGDanielle.ocallaghan, Team DC22012-10-31 20:54:56 CDTGO:0003972 RNA ligase (ATP) activity (F)PMID:333436ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 1

challenge
requireschangesLAMBD:TFADanielle.ocallaghan, Team DC22012-10-18 12:16:19 CDTGO:0043815 phosphoribosylglycinamide formyltransferase 2 activity (F)PMID:333436ECO:0000314 direct assay evidence used in manual assertion

Table 4: Assay B for TFA and the standard assay for RNA cyclization were

carried out with 0.3 and 0.003 jig ofRNA ligase, respectively. Both tail fibers and RNA ligase were filtered through Sephadex G-50 before use. Extents of TFA and RNA cyclization were measured after 0, 15, 30, 60, 120, and 180 min. The rates observed in the complete reactions (k value for TFA = 0.008 min-') were set equal to 100.

challenge
requireschangesLAMBD:TFADanielle.ocallaghan, Team DC22012-10-18 12:09:03 CDTGO:0043815 phosphoribosylglycinamide formyltransferase 2 activity (F)PMID:333436ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1: The finding that gen.63 am mutations eliminate both TFA

and RNA ligase activities suggests that both may reside in the protein gp63. This suggestion was proven correct in two ways. First, in amM69-infected supF host cells, both TFA and RNA ligase activities were shown to be markedly more heat labile than the corresponding activities in standard-type T4D-infected supF cells (Fig. 1). This result indicates that gp63 is responsible for both activities.

challenge
unacceptableHUMAN:IGF1RDanielle.ocallaghan, Team DC22012-10-18 09:45:35 CDTGO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding (F)PMID:23071652ECO:0000314 direct assay evidence used in manual assertion

Figure 2. The standard curves of IGF signaling antibody array. This graph shows the binding sites of the DNA

challenge
unacceptableHUMAN:3BP2Dayna.love, Team DC22012-09-23 17:40:27 CDTGO:0048555 generative cell nucleus (C)PMID:78314ECO:0000317 genomic context evidence used in manual assertion

Fig. 1 shows the structure of the genetic mutation of human SH3BP2 that is found in tumor tissue of a patient with cherubism

challenge
acceptableCALRH:VM1KChelsea.jenney, Team DC22012-09-23 15:56:28 CDTGO:0035893 negative regulation of platelet aggregation in other organism (P)PMID:18624975ECO:0000314 direct assay evidence used in manual assertion

Fig. 1

challenge
acceptableCALRH:VM1KChelsea.jenney, Team DC22012-09-23 15:53:41 CDTGO:0008233 peptidase activity (F)PMID:18624975ECO:0000314 direct assay evidence used in manual assertion

Fig. 2B and 3

challenge
requireschangesBOVIN:CO1A1Dayna.love, Team DC22012-09-22 21:31:53 CDTGO:0032302 MutSbeta complex (C)PMID:02453ECO:0000255 match to sequence model evidence used in manual assertion

Fig 5 shows PCR products after the protein was affected by the mutated allele

challenge
requireschangesHUMAN:ANXA4Dayna.love, Team DC22012-09-22 14:23:23 CDTGO:0050673 epithelial cell proliferation (P)PMID:09525ECO:0000317 genomic context evidence used in manual assertion

Fig 1 states overexpression of ANXA4 induces cell proliferation

challenge
acceptableMOUSE:MOXD1Chelsea.jenney, Team DC22012-09-19 21:12:20 CDTGO:0016020 membrane (C)PMID:15337741ECO:0000255 match to sequence model evidence used in manual assertion

Fig. 3A

challenge
acceptableHUMAN:MOXD1Chelsea.jenney, Team DC22012-09-19 21:12:20 CDTGO:0005789 endoplasmic reticulum membrane (C)PMID:15337741ECO:0000314 direct assay evidence used in manual assertion

Fig. 6B

challenge

CACAO assessment

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Pages in category "Team DC2"

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