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Category:MichSt14A 20

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableHUMAN:LYRICReillyer, MichSt14A 202014-04-04 14:38:26 CDTGO:0016055 Wnt signaling pathway (P)PMID:24348829ECO:0000315 mutant phenotype evidence used in manual assertion

According to figure 2A, 2D, and 2E, silencing the aeg1 gene accounted for suppressed HepG2 proliferation and decreased colony formation when compared to the vector control. Thus, aeg-1 inhibits cell growth and promotes apoptosis in hepatoma HepG2 cells.

challenge
updatedbyinstructorYERPE:LCRFReillyer, MichSt14A 202014-04-04 14:10:01 CDTGO:0006355 regulation of transcription, DNA-templated (P)PMID:24658611ECO:0000315 mutant phenotype evidence used in manual assertion

According to figure 2a, activity of nine Ca2+ depletion induced promoters were decreased in cells with a mutant lcrf genotype as opposed to cells with a wildtype lcrf genotype. Thus, Ca2+ depletion induced genes are regulated by LcrF.

challenge
unacceptableMOUSE:FGF15Reillyer, MichSt14A 202014-04-03 21:23:39 CDTGO:0060557 positive regulation of vitamin D biosynthetic process (P)PMID:24688219ECO:0000314 direct assay evidence used in manual assertion

According to figure 1C, Fgf15 mRNA expression in the ileum was significantly increased in the mice fed the 0.1% Pi diet compared with groups fed the 0.6% or 1.2% Pi diet. Therefore, dietary Pi restriction up-regulates ileal Fgf15 gene expression.

challenge
unacceptableMOUSE:AZI1Reillyer, MichSt14A 202014-04-03 20:51:28 CDTGO:0044441 ciliary part (C)PMID:24550735ECO:0000315 mutant phenotype evidence used in manual assertion

According to figure 4a, depletion of AZI1 reduced cilia formation by approximately 50%. Therefore, the azi1 gene positively influences cilia formation.

challenge
unacceptableCHICK:FPPSReillyer, MichSt14A 202014-04-03 19:08:52 CDTGO:0004337 geranyltranstransferase activity (F)PMID:24206759ECO:0000314 direct assay evidence used in manual assertion

According to figure 4, fdps genes were upregulated in abdominal fat, subcutaneous fat, and breast muscle tissues in WRR male chickens as opposed to XH male chickens. It can be inferred that the fast growing WRR chickens gain fat and muscle quicker as a result of abnormally upregulated genes, including fdps. Fdps plays a key role in fat and muscle development.

challenge
updatedbyinstructorCHICK:SOX21Reillyer, MichSt14A 202014-04-03 18:40:06 CDTGO:0048839 inner ear development (P)PMID:23071561ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 4 shows that sox21 promotes hair cell formation in vestibular patches during late embryonic stages. In vestibular patches, the majority of pTRE-eGFP transfected cells had support cell rather than hair cell morphologies. However, the majority of cells transfected with pTRE-eGFP-Sox21 had hair cell morphology.

challenge
updatedbyinstructor?Reillyer, MichSt14A 202014-04-03 16:10:14 CDTGO:0061304 retinal blood vessel morphogenesis (P)PMID:23093773ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 1a shows electron micrographs of murine retinas - a wildtype control, and a mutant 3 days after deleting the vegfa gene. The mutants lack choriocapillaris normally observed in controls. Thus, vegfa deletion results in complete ablation of the choriocapillaris.

challenge
updatedbyinstructorHUMAN:ATG7Reillyer, MichSt14A 202014-04-03 11:40:25 CDTGO:0006914 autophagy (P)PMID:24681637ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 indicates that cells treated to knockout atg7 showed no presence of LC3-II when treated with MitoQ. Wildtype cells treated with MitoQ showed sufficient levels of LC3-II. The presence of LC3-II is used to indicate autophagy. Thus, atg7 is necessary for MitoQ-induced autophagy.

challenge

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