Category:GO:1990270 ! platelet-derived growth factor receptor-ligand complex

name: platelet-derived growth factor receptor-ligand complex
namespace: cellular_component
def: "A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerization and activation. PDGFs are involved in a wide variety of signaling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes." [GOC:bhm, PMID:11331882]
comment: An example of this is PDGFA-PGFRA in human (UniProt symbols P04085, P16234) in PMID:7679113 (inferred from direct assay).
synonym: "PDGF complex" BROAD []
synonym: "PDGF receptor-ligand complex" EXACT []
synonym: "PDGF-AA-receptor alpha complex" NARROW []
synonym: "PDGF-AB-receptor alpha complex" NARROW []
synonym: "PDGF-AB-receptor beta complex" NARROW []
synonym: "PDGF-BB-receptor alpha complex" NARROW []
synonym: "PDGF-BB-receptor alpha-beta complex" NARROW []
synonym: "PDGF-BB-receptor beta complex" NARROW []
synonym: "PDGF-CC-receptor alpha complex" NARROW []
synonym: "PDGF-CC-receptor alpha-beta complex" NARROW []
synonym: "PDGF-CC-receptor beta complex" NARROW []
synonym: "PDGF-DD-receptor alpha-beta complex" NARROW []
synonym: "PDGF-DD-receptor beta complex" NARROW []
synonym: "receptor-ligand complex" BROAD []
is_a: GO:0098797 ! plasma membrane protein complex
relationship: has_part: GO:0043235 ! receptor complex
relationship: has_part: GO:1990265 ! platelet-derived growth factor complex

AmiGO <GOterm>GO:1990270</GOterm>
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