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Category:GO:0140766 ! siRNA-mediated gene silencing

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DAG for GO:0140766id: GO:0140766

name: siRNA-mediated gene silencing
namespace: biological_process
def: "A post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) elicit silencing of specific target genes. siRNAs are 21-23 nucleotide RNA duplexes that are fully complementary to their target mRNA. siRNAs can be exported and act in other cells, including in germline cells. Once incorporated into a RNA-induced silencing complex (RISC), siRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the mRNA or mRNA translational repression. siRNAs are present in lower animals and plants, but not found in mammals; whereas miRNAs are present in all the animals and in plants." [PMID:26372022]
synonym: "gene silencing by siRNA" EXACT []
synonym: "post-transcriptional gene silencing by siRNA" EXACT []
synonym: "posttranscriptional gene silencing by siRNA" EXACT []
synonym: "siRNA-mediated PTGS" EXACT []
is_a: GO:0035194 ! RNA-mediated post-transcriptional gene silencing

AmiGO <GOterm>GO:0140766</GOterm>
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