Category:GO:0140536 ! nuclear receptor corepressor activity

name: nuclear receptor corepressor activity
namespace: molecular_function
def: "A transcription corepressor activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Nuclear receptor corepressors often act by altering chromatin structure and modifications. For example, one class of transcription nuclear receptor corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators." [PMID:7566114, PMID:7566126, PMID:9238851]
comment: For usage guidance, see comment in GO:0003712 ; transcription coregulator activity.
synonym: "nuclear corepressor activity" BROAD []
is_a: GO:0003714 ! transcription corepressor activity
relationship: part_of: GO:0000122 ! negative regulation of transcription by RNA polymerase II

AmiGO <GOterm>GO:0140536</GOterm>
Gene Ontology Home