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Category:GO:0102357 ! mithramycin dehydrogenase (NADPH) activity
name: mithramycin dehydrogenase (NADPH) activity
namespace: molecular_function
def: "Catalysis of the reaction: mithramycin DK + NADPH + H+ = iso-mithramycin + NADP+. Note that iso-mithramycin (iso-MTM) is a C2-epimer of mithramycin. This intermediate appears to be biologically important because it is non-toxic, then exported out of the cell and finally spontaneously epimerized into the toxic mithramycin. This could represent a self-resistance mechanism against MTM toxicity." [PMID:31702856]
xref: MetaCyc:RXN-13385
is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
AmiGO
<GOterm>GO:0102357</GOterm>
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