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Category:GO:0097696 ! cell surface receptor signaling pathway via STAT

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DAG for GO:0097696id: GO:0097696

name: cell surface receptor signaling pathway via STAT
namespace: biological_process
def: "An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins." [GOC:rjd, PMID:21534947, PMID:24587195]
comment: In most species, STAT proteins are activated by members of the JAK (Janus Activated Kinase) family of tyrosine kinases; the term GO:0007259 'JAK-STAT cascade' describes this specificity. In other cases, such as D. discoideum, no JAK orthologs are known, and STAT proteins are activated by tyrosine kinase-like proteins.
synonym: "kinase activated-STAT cascade" EXACT []
synonym: "kinase-STAT cascade" EXACT []
synonym: "receptor signaling pathway via STAT" EXACT []
synonym: "STAT signalling pathway" EXACT []
is_a: GO:0007166 ! cell surface receptor signaling pathway

AmiGO <GOterm>GO:0097696</GOterm>
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