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Category:GO:0080188 ! gene silencing by siRNA-directed DNA methylation
name: gene silencing by siRNA-directed DNA methylation
namespace: biological_process
def: "A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism." [PMID:21420348, PMID:33031395]
comment: This process has been shown in plants and in yeasts, but so far has not been detected in vertebrates, organisms that lack RNA-dependent RNA polymerase.
synonym: "gene silencing by RNA-directed DNA methylation" RELATED []
synonym: "RdDM" EXACT []
synonym: "RNA-directed DNA methylation" RELATED []
is_a: GO:0006346 ! DNA methylation-dependent heterochromatin formation
is_a: GO:0031048 ! regulatory ncRNA-mediated heterochromatin formation
AmiGO
<GOterm>GO:0080188</GOterm>
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