Category:GO:0071164 ! RNA cap trimethylguanosine synthase activity

name: RNA cap trimethylguanosine synthase activity
namespace: molecular_function
def: "Catalysis of two successive methyl transfer reactions from AdoMet to the N-2 atom of guanosine, thereby converting 7-methylguanosine in an RNA cap to 2,2,7 trimethylguanosine." [PMID:11983179, PMID:18775984]
comment: A 2,2,7-trimethylguanosine (TMG) cap is found on many RNA polymerase II transcribed small noncoding RNAs including small nuclear RNA (snRNA), small nucleolar RNA (snoRNA) and telomerase RNA. It is also found on nematode mRNAs that undergo trans-splicing of a 5'-capped leader sequence.
synonym: "cap hypermethylase activity" EXACT [PMID:11983179]
synonym: "RNA trimethylguanosine synthase activity" EXACT []
synonym: "small nuclear RNA methyltransferase activity" RELATED [GOC:rl]
synonym: "snRNA methyltransferase activity" RELATED [GOC:rl]
is_a: GO:0008173 ! RNA methyltransferase activity
is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity
relationship: part_of: GO:0036261 ! 7-methylguanosine cap hypermethylation

AmiGO <GOterm>GO:0071164</GOterm>
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