GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Category:GO:0039557 ! symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
name: symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity
namespace: biological_process
def: "A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:11943871, PMID:16014964, PMID:19557165]
comment: This term is for annotation of symbiont proteins that counteract the host anti-microbial innate immune response.
synonym: "inhibition of host interferon regulatory factor-7 by virus" RELATED []
synonym: "inhibition of host IRF7 by virus" RELATED []
synonym: "suppression by virus of host interferon regulatory factor 7 activity" RELATED []
synonym: "suppression by virus of host IRF7 activity" RELATED []
synonym: "suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity" NARROW []
xref: VZ:653
is_a: GO:0039537 ! symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway
AmiGO
<GOterm>GO:0039557</GOterm>
Gene Ontology Home
The contents of this box are automatically generated. You can help by adding information to the "Notes"
Usage Notes
References
See Help:References for how to manage references in GONUTS.
This category currently contains no pages or media.
