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Category:GO:0036316 ! SREBP-SCAP complex retention in endoplasmic reticulum
name: SREBP-SCAP complex retention in endoplasmic reticulum
namespace: biological_process
def: "Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER." [GOC:bf, PMID:16525117]
comment: Consider also annotating to the cellular component term: SREBP-SCAP-Insig complex ; GO:0032937.
is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum
is_a: GO:2000639 ! negative regulation of SREBP signaling pathway
relationship: part_of: GO:0036315 ! cellular response to sterol
AmiGO
<GOterm>GO:0036316</GOterm>
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