Category:GO:0030433 ! ubiquitin-dependent ERAD pathway

name: ubiquitin-dependent ERAD pathway
namespace: biological_process
def: "The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]
comment: See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'.
synonym: "endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process" EXACT []
synonym: "endoplasmic reticulum-associated ubiqutin-dependent protein catabolism" EXACT []
synonym: "ER-associated ubiquitin-dependent protein breakdown" EXACT []
synonym: "ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:vw]
synonym: "ER-associated ubiquitin-dependent protein catabolism" EXACT []
synonym: "ER-associated ubiquitin-dependent protein degradation" EXACT []
synonym: "ERAD" BROAD []
synonym: "ubiquitin-dependent proteasomal protein catabolism of ER proteins" EXACT [GOC:bf]
is_a: GO:0036503 ! ERAD pathway
is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process

AmiGO <GOterm>GO:0030433</GOterm>
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