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Category:GO:0008657 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

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DAG for GO:0008657id: GO:0008657

name: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity
namespace: molecular_function
def: "Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah]
synonym: "DNA gyrase inhibitor activity" EXACT [GOC:dph, GOC:tb]
is_a: GO:0004857 ! enzyme inhibitor activity
is_a: GO:0072586 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity
relationship: negatively_regulates: GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
intersection_of: GO:0140678 ! molecular function inhibitor activity
intersection_of: negatively_regulates GO:0003918 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

AmiGO <GOterm>GO:0008657</GOterm>
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Pages in category "GO:0008657 ! DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"

The following 2 pages are in this category, out of 2 total.