name: receptor signaling pathway via JAK-STAT
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def: "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028]
synonym: "JAK-STAT cascade" NARROW 
synonym: "JAK-STAT signal transduction" EXACT [GOC:signaling]
is_a: GO:0097696 ! receptor signaling pathway via STAT
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