name: I-kappaB kinase/NF-kappaB signaling
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def: "The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:12773372, Reactome:R-HSA-209560]
synonym: "activation of the inhibitor of kappa kinase" RELATED 
synonym: "canonical NF-kappaB signaling cascade" EXACT [GOC:bf]
synonym: "I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling]
synonym: "I-kappaB kinase/NF-kappaB signal transduction" EXACT [GOC:signaling]
synonym: "NF-kappaB cascade" BROAD 
synonym: "p50-dependent NF-kappaB signaling" RELATED [PMID:18292232]
is_a: GO:0035556 ! intracellular signal transduction
relationship: has_part: GO:0051092 ! positive regulation of NF-kappaB transcription factor activity
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