Category:GO:0005260 ! intracellularly ATP-gated chloride channel activity

name: intracellularly ATP-gated chloride channel activity
namespace: molecular_function
alt_id: GO:0005224
def: "Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane." [PMID:24727426, PMID:9922375]
comment: This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).
synonym: "CFTR" EXACT []
synonym: "channel-conductance-controlling ATPase activity" RELATED [EC:5.6.1.6]
synonym: "cystic fibrosis transmembrane conductance regulator" NARROW []
xref: EC:5.6.1.6
xref: MetaCyc:3.6.3.49-RXN
xref: TC:3.A.1.202.1
xref: Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator
is_a: GO:0005254 ! chloride channel activity
is_a: GO:0099095 ! ligand-gated monoatomic anion channel activity
is_a: GO:0099142 ! intracellularly ATP-gated ion channel activity

AmiGO <GOterm>GO:0005260</GOterm>
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