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Category:GO:0004418 ! hydroxymethylbilane synthase activity
name: hydroxymethylbilane synthase activity
namespace: molecular_function
def: "Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4." [EC:2.5.1.61, RHEA:13185]
comment: Note that this function was formerly EC:4.3.1.8.
synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" RELATED [EC:2.5.1.61]
synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" RELATED [EC:2.5.1.61]
synonym: "HMB-synthase activity" RELATED [EC:2.5.1.61]
synonym: "porphobilinogen ammonia-lyase (polymerizing)" RELATED [EC:2.5.1.61]
synonym: "porphobilinogen deaminase activity" RELATED [EC:2.5.1.61]
synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" RELATED [EC:2.5.1.61]
synonym: "pre-uroporphyrinogen synthase activity" RELATED [EC:2.5.1.61]
synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61]
synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61]
synonym: "uroporphyrinogen synthase activity" RELATED [EC:2.5.1.61]
synonym: "uroporphyrinogen synthetase activity" RELATED [EC:2.5.1.61]
xref: EC:2.5.1.61
xref: KEGG_REACTION:R00084
xref: MetaCyc:OHMETHYLBILANESYN-RXN
xref: RHEA:13185
is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups
AmiGO
<GOterm>GO:0004418</GOterm>
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