Category:GO:0016251 ! RNA polymerase II general transcription initiation factor activity

name: RNA polymerase II general transcription initiation factor activity
namespace: molecular_function
alt_id: GO:0000983
alt_id: GO:0001075
alt_id: GO:0003703
def: "A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription." [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]
comment: General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur.
synonym: "basal RNA polymerase II transcription factor activity" EXACT []
synonym: "general RNA polymerase II transcription factor activity" EXACT []
synonym: "GTF2 activity" EXACT []
synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity" RELATED []
synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" RELATED []
synonym: "sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" RELATED []
synonym: "transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly" RELATED []
synonym: "transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding" RELATED []
is_a: GO:0140223 ! general transcription initiation factor activity
relationship: part_of: GO:0006366 ! transcription by RNA polymerase II

AmiGO <GOterm>GO:0016251</GOterm>
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