GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
CLOPE:A2IA70
Contents
| Species (Taxon ID) | Clostridium perfringens. (1502) | |
| Gene Name(s) | iap | |
| Protein Name(s) | Iota toxin | |
| External Links | ||
| UniProt | A2IA70 | |
| EMBL | EF179380 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006915 |
apoptotic process |
ECO:0000270 |
P |
Detection of cleaved PARP-1 and caspace-3 are hallmarks of apoptosis. Figure 2B shows the detection of cleaved PARP-1 and caspace-3 in cells incubated with both Ia and Ib but not in cell incubated with just Ia or Ib. Both Ia and Ib of the toxin are needed for induction of the apoptotic process. |
complete | |||||
| GO:0008219 |
cell death |
ECO:0000314 |
P |
Figure 2A is a measurement if cell viability that shows a decreased cell viability at 24 hours after toxin (Ia and Ib)exposure compared to 3 hours after. |
complete | |||||
| GO:0008219 |
cell death |
ECO:0000314 |
P |
Figure 2A is a measurement if cell viability of cells which were treated with Iota toxin Ia and Ib. Decreased cell viability was seen at 24 hours independent of whether or not the toxin was removed after three hours. |
complete | |||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Hilger, H et al. (2009) The long-lived nature of clostridium perfringens iota toxin in mammalian cells induces delayed apoptosis. Infect. Immun. 77 5593-601 PubMed GONUTS page
