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CHLAE:CATL1

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Species (Taxon ID) Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops). (9534)
Gene Name(s) CTSL (synonyms: CTSL1)
Protein Name(s) Cathepsin L1

Cathepsin L Major excreted protein MEP Cathepsin L1 heavy chain Cathepsin L1 light chain

External Links
UniProt Q9GKL8
EMBL AF201700
ProteinModelPortal Q9GKL8
SMR Q9GKL8
MEROPS C01.032
PRIDE Q9GKL8
HOVERGEN HBG011513
GO GO:0005764
GO:0008234
InterPro IPR025661
IPR000169
IPR025660
IPR013128
IPR000668
IPR013201
PANTHER PTHR12411
Pfam PF08246
PF00112
PRINTS PR00705
SMART SM00848
SM00645
PROSITE PS00640
PS00139
PS00639

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046718

viral entry into host cell

PMID:15831716[1]

ECO:0000315

P

Fig. 1B and Fig. 2D CatL is not required for infection, but does enhance infection when CatB is activated.

complete
CACAO 2059

GO:0004197

cysteine-type endopeptidase activity

PMID:15831716[1]

ECO:0000315

F

Fig. 1B and Fig. 2B

complete
CACAO 2077

GO:0046718

viral entry into host cell

PMID:16571833[2]

ECO:0000314

P

Fig. 1A, 1C and Fig. 3(A,B,C)

complete
CACAO 2167

GO:0004197

cysteine-type endopeptidase activity

PMID:16571833[2]

ECO:0000314

F

Fig. 2

complete
CACAO 2168

part_of

GO:0005764

lysosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P07711

C

Seeded From UniProt

complete

involved_in

GO:0046718

viral entry into host cell

PMID:15831716[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046718

viral entry into host cell

PMID:16571833[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004197

cysteine-type endopeptidase activity

PMID:15831716[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004197

cysteine-type endopeptidase activity

PMID:16571833[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000668

P

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000668
InterPro:IPR013128

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0008234

cysteine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0788

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0458
UniProtKB-SubCell:SL-0158

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Chandran, K et al. (2005) Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 308 1643-5 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Schornberg, K et al. (2006) Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein. J. Virol. 80 4174-8 PubMed GONUTS page