CHICK:TIMP3

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	TIMP3 (synonyms: IMP-3)
Protein Name(s)	Metalloproteinase inhibitor 3 21 kDa protein of extracellular matrix Tissue inhibitor of metalloproteinases 3 TIMP-3
External Links
UniProt	P26652
EMBL	M94531
PIR	A43429
RefSeq	NP_990818.1
UniGene	Gga.2827
ProteinModelPortal	P26652
STRING	9031.ENSGALP00000020494
MEROPS	I35.003
Ensembl	ENSGALT00000020523
GeneID	396483
KEGG	gga:396483
CTD	7078
eggNOG	NOG250837
GeneTree	ENSGT00390000004555
HOGENOM	HOG000285981
HOVERGEN	HBG068749
InParanoid	P26652
KO	K16866
OMA	KEGYCSW
OrthoDB	EOG79GT74
PhylomeDB	P26652
TreeFam	TF317409
NextBio	20816522
PRO	PR:P26652
Proteomes	UP000000539
ExpressionAtlas	P26652
GO	GO:0005578 GO:0046872 GO:0008191
Gene3D	3.90.370.10
InterPro	IPR001134 IPR001820 IPR008993 IPR027465 IPR015612
PANTHER	PTHR11844 PTHR11844:SF6
Pfam	PF00965
SMART	SM00206
SUPFAM	SSF50242
PROSITE	PS50189 PS00288

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P16035	F		Seeded From UniProt	complete
involved_in	GO:0051045	negative regulation of membrane protein ectodomain proteolysis		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000931945 UniProtKB:P01033 UniProtKB:P35625	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000931946 RGD:61312 RGD:621675 RGD:69077	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98752 PANTHER:PTN000931945	C		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000931945 UniProtKB:P01033	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000931945 RGD:3865 RGD:621675	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000931946 RGD:3865 RGD:69077	P		Seeded From UniProt	complete
enables	GO:0008191	metalloendopeptidase inhibitor activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025879 MGI:MGI:98753 PANTHER:PTN000931945 RGD:61312 UniProtKB:P01033	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000931945 RGD:61312 RGD:69077 UniProtKB:P01033 ZFIN:ZDB-GENE-030612-1	C		Seeded From UniProt	complete
enables	GO:0002020	protease binding		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000931945 RGD:621675 UniProtKB:P16035	F		Seeded From UniProt	complete
involved_in	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35625 ensembl:ENSP00000266085	P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35625 ensembl:ENSP00000266085	P		Seeded From UniProt	complete
involved_in	GO:0051045	negative regulation of membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P35625 ensembl:ENSP00000266085	P		Seeded From UniProt	complete
involved_in	GO:1904684	negative regulation of metalloendopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39876 ensembl:ENSMUSP00000020234	P		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39876 ensembl:ENSMUSP00000020234	P		Seeded From UniProt	complete
part_of	GO:0005604	basement membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P39876 ensembl:ENSMUSP00000020234	C		Seeded From UniProt	complete
enables	GO:0008191	metalloendopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001820 InterPro:IPR015612	F		Seeded From UniProt	complete
enables	GO:0008191	metalloendopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0483	F		Seeded From UniProt	complete
enables	GO:0004857	enzyme inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0481	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P		Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F		Seeded From UniProt	complete
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