CHICK:SPAST

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	SPAST (ECO:0000255 with HAMAP-Rule:MF_03021) (synonyms: SPG4 (ECO:0000255 with HAMAP-Rule:MF_03021))
Protein Name(s)	Spastin (ECO:0000255 with HAMAP-Rule:MF_03021)
External Links
UniProt	Q5ZK92
EMBL	EU849599 EU849600 AJ720192
RefSeq	NP_001026232.1
UniGene	Gga.21964
ProteinModelPortal	Q5ZK92
SMR	Q5ZK92
PaxDb	Q5ZK92
GeneID	421481
KEGG	gga:421481
CTD	6683
eggNOG	COG0464
HOGENOM	HOG000225146
HOVERGEN	HBG108502
InParanoid	Q5ZK92
KO	K13254
PhylomeDB	Q5ZK92
NextBio	20824244
PRO	PR:Q5ZK92
Proteomes	UP000000539
GO	GO:0005813 GO:0016021 GO:0005874 GO:0005634 GO:0048471 GO:0043014 GO:0005524 GO:0048487 GO:0008017 GO:0008568 GO:0006200 GO:0007409 GO:0007049 GO:0051301 GO:0001578 GO:0051013 GO:0031117 GO:0034214 GO:0051260
Gene3D	3.40.50.300
HAMAP	MF_03021
InterPro	IPR003593 IPR003959 IPR003960 IPR007330 IPR027417 IPR017179
Pfam	PF00004 PF04212
PIRSF	PIRSF037338
SMART	SM00382 SM00745
SUPFAM	SSF52540
PROSITE	PS00674

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0019896	axonal transport of mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYY8	P	Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QYY8	P	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	C	Seeded From UniProt	complete
involved_in	GO:0090148	membrane fission	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	P	Seeded From UniProt	complete
involved_in	GO:0051228	mitotic spindle disassembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	P	Seeded From UniProt	complete
involved_in	GO:0031468	nuclear envelope reassembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	P	Seeded From UniProt	complete
involved_in	GO:0010458	exit from mitosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	P	Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	P	Seeded From UniProt	complete
involved_in	GO:0051013	microtubule severing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	P	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	F	Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	F	Seeded From UniProt	complete
involved_in	GO:0034214	protein hexamerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	P	Seeded From UniProt	complete
colocalizes_with	GO:0015630	microtubule cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	C	Seeded From UniProt	complete
enables	GO:0008568	microtubule-severing ATPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	F	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	F	Seeded From UniProt	complete
involved_in	GO:0001578	microtubule bundle formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UBP0	P	Seeded From UniProt	complete
involved_in	GO:0031122	cytoplasmic microtubule organization	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1344353 PANTHER:PTN000553509 UniProtKB:A0A0B4KFL3	P	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039141 MGI:MGI:1344353 PANTHER:PTN000553508 SGD:S000006377 UniProtKB:O75351 UniProtKB:Q9UN37 WB:WBGene00016045 WB:WBGene00017981	F	Seeded From UniProt	complete
enables	GO:0008568	microtubule-severing ATPase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031519 FB:FBgn0039141 MGI:MGI:2387638 PANTHER:PTN000553509 UniProtKB:A0A0B4KFL3 UniProtKB:O75449 UniProtKB:Q9BW62 UniProtKB:Q9UBP0 WB:WBGene00003183 WB:WBGene00016045	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1344353 MGI:MGI:1858896 MGI:MGI:1890648 PANTHER:PTN000553509 TAIR:locus:2038678 TAIR:locus:2092025 UniProtKB:O75351 UniProtKB:Q9UBP0 UniProtKB:Q9UN37 WB:WBGene00003183 WB:WBGene00017981	C	Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019896	C	Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0019896	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E5KRP5 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E5KRP5 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
involved_in	GO:0090148	membrane fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
involved_in	GO:0051228	mitotic spindle disassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
involved_in	GO:0051013	microtubule severing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	F	Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	F	Seeded From UniProt	complete
involved_in	GO:0034214	protein hexamerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
involved_in	GO:0032506	cytokinetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
involved_in	GO:0031468	nuclear envelope reassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
involved_in	GO:0010458	exit from mitosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
enables	GO:0008568	microtubule-severing ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	F	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	F	Seeded From UniProt	complete
involved_in	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	C	Seeded From UniProt	complete
involved_in	GO:0001578	microtubule bundle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UBP0 ensembl:ENSP00000320885	P	Seeded From UniProt	complete
involved_in	GO:0051013	microtubule severing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYY8 ensembl:ENSMUSP00000024869	P	Seeded From UniProt	complete
involved_in	GO:0019896	axonal transport of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYY8 ensembl:ENSMUSP00000024869	P	Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYY8 ensembl:ENSMUSP00000024869	C	Seeded From UniProt	complete
involved_in	GO:0008089	anterograde axonal transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYY8 ensembl:ENSMUSP00000024869	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QYY8 ensembl:ENSMUSP00000024869	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003959 InterPro:IPR003960	F	Seeded From UniProt	complete
enables	GO:0008568	microtubule-severing ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017179 InterPro:IPR035106	F	Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	C	Seeded From UniProt	complete
involved_in	GO:0034214	protein hexamerization	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	P	Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	F	Seeded From UniProt	complete
enables	GO:0008568	microtubule-severing ATPase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	C	Seeded From UniProt	complete
involved_in	GO:0051013	microtubule severing	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	P	Seeded From UniProt	complete
involved_in	GO:0031117	positive regulation of microtubule depolymerization	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	C	Seeded From UniProt	complete
involved_in	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	F	Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	C	Seeded From UniProt	complete
involved_in	GO:0032506	cytokinetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000107246	P	Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0493	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

CHICK:SPAST

Contents

Annotations

Notes

References

a

b

c

d

e

g

i

m

n

p

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools