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CHICK:SOMA

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) GH
Protein Name(s) Somatotropin

Growth hormone

External Links
UniProt P08998
EMBL X12608
M35609
X17618
D10484
AF289468
AY373631
AY461843
PIR JH0630
RefSeq NP_989690.1
UniGene Gga.48744
ProteinModelPortal P08998
SMR P08998
PaxDb P08998
Ensembl ENSGALT00000000328
GeneID 378781
KEGG gga:378781
CTD 14599
eggNOG NOG26152
GeneTree ENSGT00730000111012
HOGENOM HOG000068443
HOVERGEN HBG011318
InParanoid P08998
KO K05438
OMA CRRFVES
OrthoDB EOG7F7W9X
PhylomeDB P08998
TreeFam TF332592
Reactome REACT_197052
REACT_197455
REACT_242665
NextBio 20813814
PRO PR:P08998
Proteomes UP000000539
ExpressionAtlas P08998
GO GO:0005615
GO:0005634
GO:0005886
GO:0030141
GO:0005802
GO:0046872
GO:0032869
GO:0040018
GO:0032094
Gene3D 1.20.1250.10
InterPro IPR009079
IPR012351
IPR001400
IPR018116
PANTHER PTHR11417
Pfam PF00103
PRINTS PR00836
SUPFAM SSF47266
PROSITE PS00266
PS00338

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010628

positive regulation of gene expression

PMID:24744268[1]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0013516)
  • occurs_in:(UBERON:0008975)

Seeded From UniProt

complete

enables

GO:0097153

cysteine-type endopeptidase activity involved in apoptotic process

PMID:24744268[1]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(UBERON:0013516)

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

PMID:24744268[1]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0013516)
  • occurs_in:(UBERON:0013519)

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:24744268[1]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(UBERON:0013516)
  • occurs_in:(UBERON:0013519)
  • occurs_in:(UBERON:0008975)

Seeded From UniProt

complete

involved_in

GO:0035846

oviduct epithelium development

PMID:24744268[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16253250[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050691

regulation of defense response to virus by host

PMID:11470922[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060396

growth hormone receptor signaling pathway

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151954
UniProtKB:P01241
UniProtKB:P01248

P

Seeded From UniProt

complete

involved_in

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151954
UniProtKB:P01241
UniProtKB:P01246

P

Seeded From UniProt

complete

involved_in

GO:0048513

animal organ development

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151954
RGD:2686

P

Seeded From UniProt

complete

involved_in

GO:0046427

positive regulation of receptor signaling pathway via JAK-STAT

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97762
PANTHER:PTN000151829
UniProtKB:P01236
UniProtKB:P01241

P

Seeded From UniProt

complete

involved_in

GO:0045927

positive regulation of growth

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151954
RGD:2686

P

Seeded From UniProt

complete

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151954
UniProtKB:P01241
UniProtKB:P01248

P

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151829
UniProtKB:P01246

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000151954
UniProtKB:P01241

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:1858413
MGI:MGI:95707
MGI:MGI:97606
MGI:MGI:97607
MGI:MGI:97618
MGI:MGI:97619
PANTHER:PTN000151829
RGD:2429
RGD:2686
UniProtKB:P01238
UniProtKB:P01239
UniProtKB:P01241
UniProtKB:P01246
UniProtKB:P08998
UniProtKB:P14676

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341833
MGI:MGI:97618
MGI:MGI:97619
PANTHER:PTN000151829
RGD:2686

F

Seeded From UniProt

complete

enables

GO:0005131

growth hormone receptor binding

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95707
PANTHER:PTN000151954
UniProtKB:P01241
UniProtKB:P01246

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0097153

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005179

P

Seeded From UniProt

complete

involved_in

GO:0040018

positive regulation of multicellular organism growth

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06880
ensembl:ENSMUSP00000099360

P

Seeded From UniProt

complete

involved_in

GO:0032869

cellular response to insulin stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06880
ensembl:ENSMUSP00000099360

P

Seeded From UniProt

complete

involved_in

GO:0032094

response to food

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06880
ensembl:ENSMUSP00000099360

P

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06880
ensembl:ENSMUSP00000099360

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06880
ensembl:ENSMUSP00000099360

C

Seeded From UniProt

complete

part_of

GO:0005802

trans-Golgi network

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06880
ensembl:ENSMUSP00000099360

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06880
ensembl:ENSMUSP00000099360

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06880
ensembl:ENSMUSP00000099360

C

Seeded From UniProt

complete

enables

GO:0005131

growth hormone receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P06880
ensembl:ENSMUSP00000099360

F

Seeded From UniProt

complete

enables

GO:0005131

growth hormone receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034975

F

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001400
InterPro:IPR018116
InterPro:IPR034975

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001400
InterPro:IPR018116

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034975

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005179

hormone activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0372

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Hrabia, A et al. (2014) Chicken oviduct-the target tissue for growth hormone action: effect on cell proliferation and apoptosis and on the gene expression of some oviduct-specific proteins. Cell Tissue Res. 357 363-72 PubMed GONUTS page
  2. Richards, MP et al. (2006) Characterization of turkey and chicken ghrelin genes, and regulation of ghrelin and ghrelin receptor mRNA levels in broiler chickens. Gen. Comp. Endocrinol. 145 298-310 PubMed GONUTS page
  3. Liu, HC et al. (2001) Growth hormone interacts with the Marek's disease virus SORF2 protein and is associated with disease resistance in chicken. Proc. Natl. Acad. Sci. U.S.A. 98 9203-8 PubMed GONUTS page
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page