CHICK:SAMH1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	SAMHD1
Protein Name(s)	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 dNTPase
External Links
UniProt	Q5ZJL9
EMBL	AJ720415
RefSeq	NP_001026016.1
UniGene	Gga.20678
ProteinModelPortal	Q5ZJL9
STRING	9031.ENSGALP00000001866
PaxDb	Q5ZJL9
GeneID	419125
KEGG	gga:419125
CTD	25939
eggNOG	COG1078
HOGENOM	HOG000264286
HOVERGEN	HBG054208
InParanoid	Q5ZJL9
PhylomeDB	Q5ZJL9
NextBio	20822229
PRO	PR:Q5ZJL9
Proteomes	UP000000539
GO	GO:0005634 GO:0032567 GO:0008832 GO:0003676 GO:0003723 GO:0008270 GO:0046061 GO:0051607 GO:0006203 GO:0045087 GO:0045088
Gene3D	1.10.3210.10
InterPro	IPR003607 IPR006674
Pfam	PF01966
SMART	SM00471

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0016793	triphosphoric monoester hydrolase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60710	F	Seeded From UniProt	complete
enables	GO:0008832	dGTPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60710	F	Seeded From UniProt	complete
involved_in	GO:0016446	somatic hypermutation of immunoglobulin genes	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60710	P	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	C	Seeded From UniProt	complete
enables	GO:0016793	triphosphoric monoester hydrolase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	F	Seeded From UniProt	complete
NOT\|enables	GO:0004540	ribonuclease activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	F	Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	F	Seeded From UniProt	complete
involved_in	GO:0110025	DNA strand resection involved in replication fork processing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
involved_in	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
involved_in	GO:0009264	deoxyribonucleotide catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
involved_in	GO:0046061	dATP catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
involved_in	GO:0045088	regulation of innate immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
enables	GO:0032567	dGTP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	F	Seeded From UniProt	complete
enables	GO:0008832	dGTPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	F	Seeded From UniProt	complete
involved_in	GO:0006203	dGTP catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	F	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y3Z3	F	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001348095 UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
involved_in	GO:0045088	regulation of innate immune response	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001348095 UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
enables	GO:0008832	dGTPase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10225 PANTHER:PTN000146578 UniProtKB:Q9Y3Z3	F	Seeded From UniProt	complete
involved_in	GO:0006203	dGTP catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000146578 UniProtKB:Q9Y3Z3	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000146579 UniProtKB:Q9Y3Z3	C	Seeded From UniProt	complete
involved_in	GO:0090501	RNA phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004540	P	Seeded From UniProt	complete
involved_in	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60710 ensembl:ENSMUSP00000059717	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60710 ensembl:ENSMUSP00000059717	P	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60710 ensembl:ENSMUSP00000059717	P	Seeded From UniProt	complete
enables	GO:0016793	triphosphoric monoester hydrolase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60710 ensembl:ENSMUSP00000059717	F	Seeded From UniProt	complete
involved_in	GO:0016446	somatic hypermutation of immunoglobulin genes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60710 ensembl:ENSMUSP00000059717	P	Seeded From UniProt	complete
enables	GO:0008832	dGTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60710 ensembl:ENSMUSP00000059717	F	Seeded From UniProt	complete
involved_in	GO:0110025	DNA strand resection involved in replication fork processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	P	Seeded From UniProt	complete
part_of	GO:0097197	tetraspanin-enriched microdomain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	C	Seeded From UniProt	complete
involved_in	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	P	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	P	Seeded From UniProt	complete
involved_in	GO:0046061	dATP catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	P	Seeded From UniProt	complete
involved_in	GO:0045088	regulation of innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	P	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	F	Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	C	Seeded From UniProt	complete
enables	GO:0032567	dGTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	F	Seeded From UniProt	complete
enables	GO:0016793	triphosphoric monoester hydrolase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	F	Seeded From UniProt	complete
involved_in	GO:0009264	deoxyribonucleotide catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	P	Seeded From UniProt	complete
enables	GO:0008832	dGTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	F	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	P	Seeded From UniProt	complete
involved_in	GO:0006203	dGTP catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	F	Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	F	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	F	Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Y3Z3 ensembl:ENSP00000493536	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:SAMH1

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