CHICK:RET4

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	RBP4
Protein Name(s)	Retinol-binding protein 4 Plasma retinol-binding protein PRBP RBP
External Links
UniProt	P41263
EMBL	X77960
PIR	I50675
RefSeq	NP_990569.1
UniGene	Gga.4126
PDB	1IIU
PDBsum	1IIU
ProteinModelPortal	P41263
SMR	P41263
IntAct	P41263
STRING	9031.ENSGALP00000010694
PaxDb	P41263
PRIDE	P41263
Ensembl	ENSGALT00000010708
GeneID	396166
KEGG	gga:396166
CTD	5950
eggNOG	NOG40507
GeneTree	ENSGT00510000047107
HOGENOM	HOG000293156
HOVERGEN	HBG004493
InParanoid	P41263
KO	K18271
OMA	TWYAVAK
OrthoDB	EOG747PK3
PhylomeDB	P41263
TreeFam	TF331445
Reactome	REACT_189740 REACT_197071 REACT_198054
EvolutionaryTrace	P41263
NextBio	20816220
PRO	PR:P41263
Proteomes	UP000000539
GO	GO:0030136 GO:0005615 GO:0070062 GO:0060417 GO:0060418 GO:0019904 GO:0005102 GO:0016918 GO:0019841 GO:0034632 GO:0048738 GO:0050908 GO:0048562 GO:0060059 GO:0048706 GO:0048807 GO:0006094 GO:0042593 GO:0060347 GO:0030324 GO:0030277 GO:0008584 GO:0060044 GO:0001555 GO:0051024 GO:0032024 GO:0006461 GO:0043627 GO:0032868 GO:0032526 GO:0009615 GO:0033189 GO:0042574 GO:0042572 GO:0007283 GO:0060157 GO:0060065 GO:0060068
Gene3D	2.40.128.20
InterPro	IPR012674 IPR011038 IPR002345 IPR022271 IPR022272 IPR000566 IPR002449
PANTHER	PTHR11873
Pfam	PF00061
PIRSF	PIRSF036893 PIRSF500204
PRINTS	PR00179 PR01174
SUPFAM	SSF50814
PROSITE	PS00213

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0019841	retinol binding	PMID:986177^[1]	ECO:0000353	physical interaction evidence used in manual assertion	CHEBI:17336	F	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:11738088^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
involved_in	GO:0042593	glucose homeostasis	PMID:11738088^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
involved_in	GO:0042572	retinol metabolic process	PMID:11738088^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
involved_in	GO:0032526	response to retinoic acid	PMID:11738088^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
involved_in	GO:0032024	positive regulation of insulin secretion	PMID:11738088^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
involved_in	GO:0030277	maintenance of gastrointestinal epithelium	PMID:11738088^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
enables	GO:0019841	retinol binding	PMID:11738088^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		F	Seeded From UniProt	Missing: with/from
involved_in	GO:0006094	gluconeogenesis	PMID:11738088^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
part_of	GO:0005615	extracellular space	PMID:11738088^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		C	Seeded From UniProt	Missing: with/from
involved_in	GO:0001654	eye development	PMID:11738088^[2]	ECO:0000255	match to sequence model evidence used in manual assertion		P	Seeded From UniProt	Missing: with/from
part_of	GO:0060418	yolk plasma	PMID:7748490^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0060417	yolk	PMID:7548118^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:7748490^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0034632	retinol transmembrane transporter activity	PMID:7548118^[4]	ECO:0000305	curator inference used in manual assertion	GO:0019841	F	Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	PMID:2746375^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033189	response to vitamin A	PMID:1310111^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	PMID:7548118^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:986177^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27731	F	Seeded From UniProt	complete
enables	GO:0019841	retinol binding	PMID:9270874^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0019841	retinol binding	PMID:7548118^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0019841	retinol binding	PMID:805200^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:2746375^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:1310111^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:986177^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9270874^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:7548118^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:2746375^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:1310111^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:805200^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:986177^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:573630^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001555	oocyte growth	PMID:7548118^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034633	retinol transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0034632	P	Seeded From UniProt	complete
involved_in	GO:0034633	retinol transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0034632	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02753 ensembl:ENSP00000360522	P	Seeded From UniProt	complete
involved_in	GO:0042572	retinol metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02753 ensembl:ENSP00000360522	P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02753 ensembl:ENSP00000360522	P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02753 ensembl:ENSP00000360522	P	Seeded From UniProt	complete
involved_in	GO:0030277	maintenance of gastrointestinal epithelium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02753 ensembl:ENSP00000360522	P	Seeded From UniProt	complete
enables	GO:0019841	retinol binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02753 ensembl:ENSP00000360522	F	Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02753 ensembl:ENSP00000360522	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02753 ensembl:ENSP00000360522	C	Seeded From UniProt	complete
involved_in	GO:0001654	eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02753 ensembl:ENSP00000360522	P	Seeded From UniProt	complete
enables	GO:0005501	retinoid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002449	F	Seeded From UniProt	complete
enables	GO:0034632	retinol transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002449	F	Seeded From UniProt	complete
enables	GO:0019841	retinol binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0683	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
enables	GO:0016918	retinal binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0845	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Kopelman, M et al. (1976) The interaction between retinol-binding proteins and prealbumins studied by fluorescence polarization. Biochim. Biophys. Acta 439 449-60 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Zanotti, G et al. (2001) Structure of chicken plasma retinol-binding protein. Biochim. Biophys. Acta 1550 64-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Vieira, AV et al. (1995) Retinol in avian oogenesis: molecular properties of the carrier protein. DNA Cell Biol. 14 403-10 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Vieira, AV & Schneider, WJ (1993) Transport and uptake of retinol during chicken oocyte growth. Biochim. Biophys. Acta 1169 250-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Sijtsma, SR et al. (1989) Effect of Newcastle disease virus infection on vitamin A metabolism in chickens. J. Nutr. 119 940-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 West, CE et al. (1992) Epithelia-damaging virus infections affect vitamin A status in chickens. J. Nutr. 122 333-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Natarajan, V et al. (1997) Role of the C-termini of human and chicken plasma retinol-binding proteins. Eur. J. Cell Biol. 73 316-20 PubMed GONUTS page
↑ ^8.0 ^8.1 Abe, T et al. (1975) Vitamin A transport in chicken plasma: isolation and characterization of retinol-binding protein (RBP), prealbumin (PA), and RBP--PA complex. J. Lipid Res. 16 200-10 PubMed GONUTS page
↑ Bhat, MK & Cama, HR (1979) Gonadal cell surface receptor for plasma retinol-binding protein. A method for its radioassay and studies on its level during spermatogenesis. Biochim. Biophys. Acta 587 273-81 PubMed GONUTS page

[PMID:986177-1] 1.0 ^1.1 ^1.2 ^1.3 Kopelman, M et al. (1976) The interaction between retinol-binding proteins and prealbumins studied by fluorescence polarization. Biochim. Biophys. Acta 439 449-60 PubMed GONUTS page

[PMID:11738088-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Zanotti, G et al. (2001) Structure of chicken plasma retinol-binding protein. Biochim. Biophys. Acta 1550 64-9 PubMed GONUTS page

[PMID:7748490-3] 3.0 ^3.1 Vieira, AV et al. (1995) Retinol in avian oogenesis: molecular properties of the carrier protein. DNA Cell Biol. 14 403-10 PubMed GONUTS page

[PMID:7548118-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Vieira, AV & Schneider, WJ (1993) Transport and uptake of retinol during chicken oocyte growth. Biochim. Biophys. Acta 1169 250-6 PubMed GONUTS page

[PMID:2746375-5] 5.0 ^5.1 ^5.2 Sijtsma, SR et al. (1989) Effect of Newcastle disease virus infection on vitamin A metabolism in chickens. J. Nutr. 119 940-7 PubMed GONUTS page

[PMID:1310111-6] 6.0 ^6.1 ^6.2 West, CE et al. (1992) Epithelia-damaging virus infections affect vitamin A status in chickens. J. Nutr. 122 333-9 PubMed GONUTS page

[PMID:9270874-7] 7.0 ^7.1 Natarajan, V et al. (1997) Role of the C-termini of human and chicken plasma retinol-binding proteins. Eur. J. Cell Biol. 73 316-20 PubMed GONUTS page

[PMID:805200-8] 8.0 ^8.1 Abe, T et al. (1975) Vitamin A transport in chicken plasma: isolation and characterization of retinol-binding protein (RBP), prealbumin (PA), and RBP--PA complex. J. Lipid Res. 16 200-10 PubMed GONUTS page

[PMID:573630-9] Bhat, MK & Cama, HR (1979) Gonadal cell surface receptor for plasma retinol-binding protein. A method for its radioassay and studies on its level during spermatogenesis. Biochim. Biophys. Acta 587 273-81 PubMed GONUTS page

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CHICK:RET4

Contents

Annotations

Notes

References

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