CHICK:Q8QGU2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	FKBP12.6 (ECO:0000313 with EMBL:BAB89371.1)
Protein Name(s)	Peptidyl-prolyl cis-trans isomerase (ECO:0000256 with RuleBase:RU004231)
External Links
UniProt	Q8QGU2
EMBL	AB074887
RefSeq	NP_989898.1
UniGene	Gga.2210
ProteinModelPortal	Q8QGU2
SMR	Q8QGU2
STRING	9031.ENSGALP00000026566
BindingDB	Q8QGU2
ChEMBL	CHEMBL2301
GeneID	395254
KEGG	gga:395254
CTD	2281
eggNOG	COG0545
HOGENOM	HOG000154887
HOVERGEN	HBG051623
InParanoid	Q8QGU2
KO	K09568
OrthoDB	EOG7ZGX5T
PhylomeDB	Q8QGU2
TreeFam	TF105291
NextBio	20815343
PRO	PR:Q8QGU2
GO	GO:0043231 GO:0003755 GO:0007420 GO:0009792 GO:0035050 GO:0007507 GO:0060173 GO:0030324 GO:0006457
InterPro	IPR023566 IPR001179
PANTHER	PTHR10516
Pfam	PF00254
PROSITE	PS50059

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	P		Seeded From UniProt	complete
involved_in	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	P		Seeded From UniProt	complete
involved_in	GO:0051775	response to redox state	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0051284	positive regulation of sequestering of calcium ion	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	P		Seeded From UniProt	complete
involved_in	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0048680	positive regulation of axon regeneration	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P97534	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P97534	C		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P97534	P		Seeded From UniProt	complete
involved_in	GO:0042098	T cell proliferation	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	C		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	C		Seeded From UniProt	complete
involved_in	GO:0033197	response to vitamin E	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P97534	P		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	C		Seeded From UniProt	complete
involved_in	GO:0032515	negative regulation of phosphoprotein phosphatase activity	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	P		Seeded From UniProt	complete
enables	GO:0030551	cyclic nucleotide binding	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P97534	F		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	C		Seeded From UniProt	complete
enables	GO:0019855	calcium channel inhibitor activity	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	F		Seeded From UniProt	complete
involved_in	GO:0019227	neuronal action potential propagation	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	C		Seeded From UniProt	complete
involved_in	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	P		Seeded From UniProt	complete
involved_in	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0010459	negative regulation of heart rate	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P97534	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P97534	P		Seeded From UniProt	complete
involved_in	GO:0006939	smooth muscle contraction	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	C		Seeded From UniProt	complete
enables	GO:0005528	FK506 binding	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	F		Seeded From UniProt	complete
enables	GO:0005528	FK506 binding	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P97534	F		Seeded From UniProt	complete
enables	GO:0005528	FK506 binding	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	F		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	F		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	F		Seeded From UniProt	complete
involved_in	GO:0002027	regulation of heart rate	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z2I2	P		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	PMID:12508222^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P68106	P		Seeded From UniProt	complete
involved_in	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	PMID:9857007^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014802	terminal cisterna	PMID:9857007^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:9857007^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	PMID:14511757^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:9857007^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001134)	Seeded From UniProt	complete
part_of	GO:0014802	terminal cisterna	PMID:9857007^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001134)	Seeded From UniProt	complete
involved_in	GO:0060173	limb development	PMID:14511757^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:11237759^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	PMID:12508222^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0032526	response to retinoic acid	PMID:14511757^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	PMID:14511757^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	PMID:12508222^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:14511757^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:12508222^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:14511757^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061077	chaperone-mediated protein folding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000054102 UniProtKB:Q02790 UniProtKB:Q13451	P		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336205 PANTHER:PTN001314565	C		Seeded From UniProt	complete
involved_in	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1336205 PANTHER:PTN001314565	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000054102 UniProtKB:P62942 UniProtKB:P68106 UniProtKB:Q38931 UniProtKB:Q8I4V8	C		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000188340 MGI:MGI:1336205 PANTHER:PTN000054102 PomBase:SPAC27F1.06c SGD:S000005079 UniProtKB:P18203 UniProtKB:P62942 UniProtKB:P68106 UniProtKB:Q02790 UniProtKB:Q13451 UniProtKB:Q8I4V8 WB:WBGene00001431	F		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000054102 UniProtKB:P62942 UniProtKB:P68106 WB:WBGene00001431	P		Seeded From UniProt	complete
involved_in	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	P		Seeded From UniProt	complete
involved_in	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	P		Seeded From UniProt	complete
involved_in	GO:0051775	response to redox state	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	P		Seeded From UniProt	complete
involved_in	GO:0051284	positive regulation of sequestering of calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	P		Seeded From UniProt	complete
involved_in	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	P		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	C		Seeded From UniProt	complete
involved_in	GO:0032515	negative regulation of phosphoprotein phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	P		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	C		Seeded From UniProt	complete
enables	GO:0019855	calcium channel inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	C		Seeded From UniProt	complete
involved_in	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	C		Seeded From UniProt	complete
enables	GO:0005528	FK506 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	F		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	F		Seeded From UniProt	complete
involved_in	GO:0000413	protein peptidyl-prolyl isomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P68106 ensembl:ENSP00000370373	P		Seeded From UniProt	complete
involved_in	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
involved_in	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
involved_in	GO:0051480	regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	F		Seeded From UniProt	complete
involved_in	GO:0042098	T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	C		Seeded From UniProt	complete
involved_in	GO:0030073	insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
involved_in	GO:0019227	neuronal action potential propagation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	C		Seeded From UniProt	complete
involved_in	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
involved_in	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
involved_in	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
involved_in	GO:0010459	negative regulation of heart rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
involved_in	GO:0006939	smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
enables	GO:0005528	FK506 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	F		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	F		Seeded From UniProt	complete
involved_in	GO:0002027	regulation of heart rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2I2 ensembl:ENSMUSP00000020964	P		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.2.1.8	F		Seeded From UniProt	complete
enables	GO:0003755	peptidyl-prolyl cis-trans isomerase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0697	F		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000413783	F		Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	PMID:14511757^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
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Notes

References

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↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 ^1.42 ^1.43 ^1.44 ^1.45 ^1.46 ^1.47 ^1.48 ^1.49 Yazawa, S et al. (2003) Heart-selective expression of the chicken FK506-binding protein (FKBP) 12.6 gene during embryonic development. Dev. Dyn. 226 33-41 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Qi, Y et al. (1998) FK-binding protein is associated with the ryanodine receptor of skeletal muscle in vertebrate animals. J. Biol. Chem. 273 34813-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Yazawa, S et al. (2003) Gene expression of FK506-binding proteins 12.6 and 12 during chicken development. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 136 391-9 PubMed GONUTS page
↑ Jeyakumar, LH et al. (2001) FKBP binding characteristics of cardiac microsomes from diverse vertebrates. Biochem. Biophys. Res. Commun. 281 979-86 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12508222-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 ^1.42 ^1.43 ^1.44 ^1.45 ^1.46 ^1.47 ^1.48 ^1.49 Yazawa, S et al. (2003) Heart-selective expression of the chicken FK506-binding protein (FKBP) 12.6 gene during embryonic development. Dev. Dyn. 226 33-41 PubMed GONUTS page

[PMID:9857007-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Qi, Y et al. (1998) FK-binding protein is associated with the ryanodine receptor of skeletal muscle in vertebrate animals. J. Biol. Chem. 273 34813-9 PubMed GONUTS page

[PMID:14511757-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Yazawa, S et al. (2003) Gene expression of FK506-binding proteins 12.6 and 12 during chicken development. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 136 391-9 PubMed GONUTS page

[PMID:11237759-4] Jeyakumar, LH et al. (2001) FKBP binding characteristics of cardiac microsomes from diverse vertebrates. Biochem. Biophys. Res. Commun. 281 979-86 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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