CHICK:Q8JIV2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	CDKN1B (ECO:0000313 with Ensembl:ENSGALP00000036494)
Protein Name(s)	Cyclin-dependent kinase inhibitor p27 Kip1 (ECO:0000313 with EMBL:AAM22491.1) Uncharacterized protein (ECO:0000313 with EMBL:CAH65308.1, ECO:0000313 with Ensembl:ENSGALP00000036494)
External Links
UniProt	Q8JIV2
EMBL	AADN03001537 AY094490 AJ851674
RefSeq	NP_989587.1
UniGene	Gga.17250
SMR	Q8JIV2
STRING	9031.ENSGALP00000022990
Ensembl	ENSGALT00000037288
GeneID	374106
KEGG	gga:374106
CTD	1027
eggNOG	NOG245842
GeneTree	ENSGT00530000063588
HOGENOM	HOG000294081
HOVERGEN	HBG073988
KO	K06624
OMA	YPKPSAC
OrthoDB	EOG7GJ6HD
PhylomeDB	Q8JIV2
Reactome	REACT_196871 REACT_197816 REACT_198076 REACT_202415 REACT_209177 REACT_214700 REACT_231569 REACT_232216 REACT_234489
NextBio	20813624
Proteomes	UP000000539
GO	GO:0005829 GO:0005634 GO:0004861 GO:0008656 GO:0016301 GO:0048102 GO:0071236 GO:0071285 GO:0071407 GO:0000082 GO:0048839 GO:0071850 GO:0043066 GO:0030308 GO:0051271 GO:0045736 GO:0060770 GO:0045930 GO:0045892 GO:0008284 GO:0031116 GO:0045732 GO:0006813 GO:0007605
InterPro	IPR003175 IPR029843
PANTHER	PTHR10265 PTHR10265:SF9
Pfam	PF02234

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0051087	chaperone binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002567658 RGD:69062	F	Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000814137 UniProtKB:P46527 ZFIN:ZDB-GENE-040123-1	P	Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN000814137 RGD:69062 UniProtKB:P46527	P	Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000814137 UniProtKB:P46527	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 RGD:69062 UniProtKB:P46527	P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 UniProtKB:P46527	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 RGD:69062 UniProtKB:P46527	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 RGD:69062 UniProtKB:P46527	C	Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 UniProtKB:P46527	F	Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104565 PANTHER:PTN002567658 UniProtKB:P46527	P	Seeded From UniProt	complete
involved_in	GO:1905179	negative regulation of cardiac muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:1902746	regulation of lens fiber cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0071850	mitotic cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0071236	cellular response to antibiotic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0051271	negative regulation of cellular component movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0031116	positive regulation of microtubule polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	F	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0007096	regulation of exit from mitosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:0006813	potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	C	Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	F	Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46414 ensembl:ENSMUSP00000065832	P	Seeded From UniProt	complete
involved_in	GO:1904706	negative regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:1904030	negative regulation of cyclin-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0071850	mitotic cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0071285	cellular response to lithium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0048102	autophagic cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	C	Seeded From UniProt	complete
involved_in	GO:0042326	negative regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
part_of	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	C	Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F	Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	C	Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F	Seeded From UniProt	complete
enables	GO:0004860	protein kinase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	F	Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46527 ensembl:ENSP00000228872	P	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6I9V6 ensembl:ENSP00000228872	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6I9V6 ensembl:ENSP00000228872	C	Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175 InterPro:IPR029843	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175 InterPro:IPR029843	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029843	C	Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003175	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029843	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

CHICK:Q8JIV2

Contents

Annotations

Notes

References

a

c

d

e

g

h

i

k

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools