CHICK:Q3C2H5

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	Six1 (ECO:0000313 with EMBL:BAE46752.1)
Protein Name(s)	Sine oculis-related homeobox 1 homolog (ECO:0000313 with EMBL:BAE46752.1)
External Links
UniProt	Q3C2H5
EMBL	AB199734
RefSeq	NP_001038150.1
UniGene	Gga.20089
ProteinModelPortal	Q3C2H5
GeneID	693262
KEGG	gga:693262
CTD	6495
HOVERGEN	HBG003609
KO	K15614
PhylomeDB	Q3C2H5
NextBio	20902529
PRO	PR:Q3C2H5
GO	GO:0005634 GO:0043565 GO:0006355
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR009057
Pfam	PF00046
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0048856	anatomical structure development	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102780 MGI:MGI:106034 PANTHER:PTN000044272	P	Seeded From UniProt	complete
involved_in	GO:0048741	skeletal muscle fiber development	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002571893 ZFIN:ZDB-GENE-040426-2308	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102764 MGI:MGI:106034 MGI:MGI:106220 PANTHER:PTN000044272 RGD:620909 UniProtKB:O95343	P	Seeded From UniProt	complete
involved_in	GO:0014857	regulation of skeletal muscle cell proliferation	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002571893 ZFIN:ZDB-GENE-040426-2308 ZFIN:ZDB-GENE-040718-155	P	Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102780 PANTHER:PTN002571893	P	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102780 PANTHER:PTN000044272	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003460 MGI:MGI:102764 MGI:MGI:102778 MGI:MGI:102780 MGI:MGI:106034 MGI:MGI:106220 MGI:MGI:1341840 PANTHER:PTN000044272 RGD:620906 UniProtKB:Q15475 WB:WBGene00000453 WB:WBGene00000455 WB:WBGene00006775	C	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000044272 ZFIN:ZDB-GENE-040718-155	F	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000044272 dictyBase:DDB_G0272967	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15475 ensembl:ENSP00000247182	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15475 ensembl:ENSP00000247182	F	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15475 ensembl:ENSP00000247182	F	Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15475 ensembl:ENSP00000247182	P	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15475 ensembl:ENSP00000247182	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15475 ensembl:ENSP00000247182	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15475 ensembl:ENSP00000247182	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15475 ensembl:ENSP00000247182	F	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15475 ensembl:ENSP00000247182	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q15475 ensembl:ENSP00000247182	F	Seeded From UniProt	complete
involved_in	GO:2001014	regulation of skeletal muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0090103	cochlea morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0072513	positive regulation of secondary heart field cardioblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0072193	ureter smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0072172	mesonephric tubule formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0072107	positive regulation of ureteric bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0072095	regulation of branch elongation involved in ureteric bud branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0072075	metanephric mesenchyme development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0071599	otic vesicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0061551	trigeminal ganglion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0061197	fungiform papilla morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0061055	myotome development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0051451	myoblast migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0050678	regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0048839	inner ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0048704	embryonic skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0048699	generation of neurons	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0048665	neuron fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0045664	regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0043586	tongue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	F	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0042474	middle ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0042472	inner ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0035909	aorta morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0030910	olfactory placode formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0021610	facial nerve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0014842	regulation of skeletal muscle satellite cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0008582	regulation of synaptic growth at neuromuscular junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0007519	skeletal muscle tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	F	Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0001759	organ induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62231 ensembl:ENSMUSP00000059026	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031278	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031278	P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031278	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
involved_in	GO:0048513	animal organ development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR031278	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0371	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000040	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000401037	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000401037	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:Q3C2H5

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Notes

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