CHICK:Q06900

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	ChALK5 (ECO:0000313 with EMBL:BAA03357.2) (synonyms: TGFBR1 (ECO:0000313 with Ensembl:ENSGALP00000020569))
Protein Name(s)	Activin like receptor kinase 5 (ECO:0000313 with EMBL:BAA03357.2) Uncharacterized protein (ECO:0000313 with Ensembl:ENSGALP00000020569)
External Links
UniProt	Q06900
EMBL	AADN03002802 D14460
PIR	A56693
RefSeq	NP_989577.1
UniGene	Gga.143
SMR	Q06900
IntAct	Q06900
STRING	9031.ENSGALP00000020569
Ensembl	ENSGALT00000020598
GeneID	374094
KEGG	gga:374094
CTD	7046
eggNOG	COG0515
GeneTree	ENSGT00760000118876
HOGENOM	HOG000230587
HOVERGEN	HBG054502
KO	K04674
OMA	RDMIELT
OrthoDB	EOG7Q8CN3
PhylomeDB	Q06900
TreeFam	TF314724
Reactome	REACT_195006 REACT_195008 REACT_198125 REACT_211903 REACT_214793
NextBio	20813613
PRO	PR:Q06900
Proteomes	UP000000539
GO	GO:0005623 GO:0005768 GO:0016021 GO:0005886 GO:0043235 GO:0005923 GO:0005524 GO:0005057 GO:0004702 GO:0050431 GO:0005025 GO:0000186 GO:0001525 GO:0009952 GO:0048844 GO:0060317 GO:0030199 GO:0048701 GO:0042118 GO:0043542 GO:0008354 GO:0035556 GO:0001822 GO:0002088 GO:0048762 GO:0032331 GO:0001937 GO:2001237 GO:0048663 GO:0060021 GO:0060017 GO:0060389 GO:0018105 GO:0018107 GO:0060037 GO:2001235 GO:0030307 GO:0051272 GO:0001938 GO:0051491 GO:0010628 GO:0010862 GO:0051897 GO:0060391 GO:0045893 GO:0009791 GO:0010717 GO:0010468 GO:0043393 GO:0031396 GO:0070723 GO:0048538 GO:0007179
InterPro	IPR000472 IPR011009 IPR000719 IPR017441 IPR008271 IPR003605 IPR000333
PANTHER	PTHR23255
Pfam	PF01064 PF00069 PF08515
SMART	SM00467
SUPFAM	SSF56112
PROSITE	PS51256 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0005114	type II transforming growth factor beta receptor binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
NOT\|involved_in	GO:0048762	mesenchymal cell differentiation	PMID:10885742^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0070723	response to cholesterol	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0070723	response to cholesterol	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
NOT\|enables	GO:0050431	transforming growth factor beta binding	PMID:10885742^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0060021	roof of mouth development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0060017	parathyroid gland development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0051272	positive regulation of cellular component movement	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	F		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
involved_in	GO:0048870	cell motility	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
involved_in	GO:0031396	regulation of protein ubiquitination	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	C		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0043393	regulation of protein binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:8167376^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	C		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0008354	germ cell migration	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q64729	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	F		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:10885742^[1]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P36897	C		Seeded From UniProt	complete
involved_in	GO:1905223	epicardium morphogenesis	PMID:10885742^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	PMID:10885742^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64729	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:8167376^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:8167376^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:P01137	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8167376^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0010227) part_of:(UBERON:0006283)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12393881^[3]	ECO:0000305	curator inference used in manual assertion	GO:0005025	C		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:12393881^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002129)	Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:12393881^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0002129)	Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	PMID:12393881^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002129)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:12393881^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002129)	Seeded From UniProt	complete
involved_in	GO:0060317	cardiac epithelial to mesenchymal transition	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048762	mesenchymal cell differentiation	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15766759^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10885742^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042118	endothelial cell activation	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0010717	regulation of epithelial to mesenchymal transition	PMID:10885742^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010717	regulation of epithelial to mesenchymal transition	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0010692	regulation of alkaline phosphatase activity	PMID:15766759^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:P29332	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:O42486	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q8AYD0	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:O93467	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q8UVG3	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q6B0K7	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q90X15	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q9DDG3	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	UniProtKB:Q8UWC8	P		Seeded From UniProt	complete
part_of	GO:0005623	cell	PMID:10075204^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:10885742^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	PMID:17250821^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050431	transforming growth factor beta binding	PMID:10885742^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01137	F		Seeded From UniProt	complete
enables	GO:0048185	activin binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011300 MGI:MGI:1338944 PANTHER:PTN001147434 RGD:621789 UniProtKB:P36896	F		Seeded From UniProt	complete
part_of	GO:0048179	activin receptor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011300 PANTHER:PTN001147434 RGD:621789 UniProtKB:P36896 UniProtKB:Q8NER5	C		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:621789 UniProtKB:O00238 UniProtKB:P36894 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000583675 UniProtKB:P27037 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:P37173 UniProtKB:Q13705	C		Seeded From UniProt	complete
involved_in	GO:0032924	activin receptor signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011300 MGI:MGI:1338944 PANTHER:PTN001147434 UniProtKB:P36896 UniProtKB:Q06900	P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102806 MGI:MGI:87911 MGI:MGI:87912 PANTHER:PTN000583675 RGD:71082 UniProtKB:P36896 UniProtKB:P36897 UniProtKB:Q13705 UniProtKB:Q8NER5	F		Seeded From UniProt	complete
involved_in	GO:0007389	pattern specification process	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338938 MGI:MGI:87912 PANTHER:PTN000583675	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003716 MGI:MGI:1338946 MGI:MGI:87911 MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 RGD:3852 RGD:620200 RGD:69651 RGD:70964 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 UniProtKB:Q04771 UniProtKB:Q06900 UniProtKB:Q90ZK6	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87911 PANTHER:PTN000583675 RGD:69651 RGD:70964 UniProtKB:P36896 UniProtKB:P37023 UniProtKB:Q04771 UniProtKB:Q13873	C		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001147434 RGD:3852 UniProtKB:P36897 UniProtKB:Q06900	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98728 MGI:MGI:98729 PANTHER:PTN000583675 UniProtKB:A0A0B4KG59 UniProtKB:P36897 UniProtKB:P37023 UniProtKB:P37173 ZFIN:ZDB-GENE-070618-1	F		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:2001235	positive regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0070723	response to cholesterol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
enables	GO:0070411	I-SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	F		Seeded From UniProt	complete
involved_in	GO:0060391	positive regulation of SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0060389	pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0051272	positive regulation of cellular component movement	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0048870	cell motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	C		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	C		Seeded From UniProt	complete
involved_in	GO:0031396	regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	F		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	C		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	F		Seeded From UniProt	complete
enables	GO:0005114	type II transforming growth factor beta receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	F		Seeded From UniProt	complete
enables	GO:0005025	transforming growth factor beta receptor activity, type I	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	F		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36897 ensembl:ENSP00000447297	P		Seeded From UniProt	complete
involved_in	GO:1905223	epicardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:1905075	positive regulation of tight junction disassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0070723	response to cholesterol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0060982	coronary artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0060043	regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0060037	pharyngeal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0060021	roof of mouth development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0060017	parathyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0048663	neuron fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	F		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0043393	regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0008354	germ cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	F		Seeded From UniProt	complete
enables	GO:0005024	transforming growth factor beta-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	F		Seeded From UniProt	complete
involved_in	GO:0003223	ventricular compact myocardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0003222	ventricular trabecula myocardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0002088	lens development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0001937	negative regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q64729 ensembl:ENSMUSP00000007757	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472 InterPro:IPR003605	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR003605 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003605 InterPro:IPR008271	P		Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472 InterPro:IPR003605	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 ^1.42 ^1.43 ^1.44 ^1.45 ^1.46 ^1.47 ^1.48 ^1.49 ^1.50 ^1.51 ^1.52 ^1.53 ^1.54 ^1.55 ^1.56 ^1.57 ^1.58 ^1.59 ^1.60 ^1.61 ^1.62 ^1.63 ^1.64 ^1.65 ^1.66 ^1.67 ^1.68 ^1.69 ^1.70 ^1.71 ^1.72 ^1.73 ^1.74 ^1.75 ^1.76 ^1.77 Lai, YT et al. (2000) Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev. Biol. 222 1-11 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Barnett, JV et al. (1994) Cloning and developmental expression of the chick type II and type III TGF beta receptors. Dev. Dyn. 199 12-27 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Ward, SM et al. (2002) Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. J. Biol. Chem. 277 50183-9 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 Mercado-Pimentel, ME et al. (2007) Endoglin and Alk5 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev. Biol. 304 420-32 PubMed GONUTS page
↑ ^5.0 ^5.1 Desgrosellier, JS et al. (2005) Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev. Biol. 280 201-10 PubMed GONUTS page
↑ Richiert, DM & Ireland, ME (1999) TGF-beta elicits fibronectin secretion and proliferation in cultured chick lens epithelial cells. Curr. Eye Res. 18 62-71 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10885742-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 ^1.18 ^1.19 ^1.20 ^1.21 ^1.22 ^1.23 ^1.24 ^1.25 ^1.26 ^1.27 ^1.28 ^1.29 ^1.30 ^1.31 ^1.32 ^1.33 ^1.34 ^1.35 ^1.36 ^1.37 ^1.38 ^1.39 ^1.40 ^1.41 ^1.42 ^1.43 ^1.44 ^1.45 ^1.46 ^1.47 ^1.48 ^1.49 ^1.50 ^1.51 ^1.52 ^1.53 ^1.54 ^1.55 ^1.56 ^1.57 ^1.58 ^1.59 ^1.60 ^1.61 ^1.62 ^1.63 ^1.64 ^1.65 ^1.66 ^1.67 ^1.68 ^1.69 ^1.70 ^1.71 ^1.72 ^1.73 ^1.74 ^1.75 ^1.76 ^1.77 Lai, YT et al. (2000) Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation. Dev. Biol. 222 1-11 PubMed GONUTS page

[PMID:8167376-2] 2.0 ^2.1 ^2.2 ^2.3 Barnett, JV et al. (1994) Cloning and developmental expression of the chick type II and type III TGF beta receptors. Dev. Dyn. 199 12-27 PubMed GONUTS page

[PMID:12393881-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Ward, SM et al. (2002) Transforming growth factor beta (TGFbeta ) signaling via differential activation of activin receptor-like kinases 2 and 5 during cardiac development. Role in regulating parasympathetic responsiveness. J. Biol. Chem. 277 50183-9 PubMed GONUTS page

[PMID:17250821-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 ^4.11 ^4.12 ^4.13 Mercado-Pimentel, ME et al. (2007) Endoglin and Alk5 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev. Biol. 304 420-32 PubMed GONUTS page

[PMID:15766759-5] 5.0 ^5.1 Desgrosellier, JS et al. (2005) Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev. Biol. 280 201-10 PubMed GONUTS page

[PMID:10075204-6] Richiert, DM & Ireland, ME (1999) TGF-beta elicits fibronectin secretion and proliferation in cultured chick lens epithelial cells. Curr. Eye Res. 18 62-71 PubMed GONUTS page

[PMID:21873635-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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