CHICK:PRGR

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	PGR (synonyms: NR3C3)
Protein Name(s)	Progesterone receptor PR Nuclear receptor subfamily 3 group C member 3
External Links
UniProt	P07812
EMBL	Y00092 M13972 M37518 M37518 M14278 M14279 M14280 M32732 M31104 M32726 M32727 M32728 M32729 M32730 M32732 M31104 M32726 M32727 M32728 M32729 M32730 M31104 M31104
PIR	A35466
RefSeq	NP_990593.1
UniGene	Gga.705
ProteinModelPortal	P07812
SMR	P07812
BioGrid	676458
DIP	DIP-79N
STRING	9031.ENSGALP00000027736
BindingDB	P07812
ChEMBL	CHEMBL3304
PaxDb	P07812
PRIDE	P07812
GeneID	396198
KEGG	gga:396198
CTD	5241
eggNOG	NOG273252
HOGENOM	HOG000290653
HOVERGEN	HBG007583
InParanoid	P07812
KO	K08556
PhylomeDB	P07812
Reactome	REACT_197054 REACT_258806
NextBio	20816250
PRO	PR:P07812
Proteomes	UP000000539
ExpressionAtlas	P07812
GO	GO:0005737 GO:0005576 GO:0005634 GO:0004879 GO:0000978 GO:0001077 GO:0005496 GO:0003707 GO:0008270 GO:0002070 GO:0010629 GO:0001542 GO:0050847 GO:0050678
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR008946 IPR000536 IPR000128 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF02161 PF00105
PRINTS	PR00544 PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:1990239	steroid hormone binding	PMID:10811660^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:10811660^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	PMID:2779568^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0000993)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:2779568^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000993) exists_during:(GO:0071393) part_of:(GO:0043235)	Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	PMID:2779568^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B3VHV2 UniProtKB:B6EAX2 UniProtKB:P08106 UniProtKB:Q7SX63	F	occurs_in:(UBERON:0000993) occurs_in:(GO:0005829)\|occurs_in:(UBERON:0000993) occurs_in:(GO:0005634) happens_during:(GO:0071393)	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:2779568^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11501	F	occurs_in:(UBERON:0000993) occurs_in:(GO:0005829)	Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:2779568^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	occurs_in:(UBERON:0000993) occurs_in:(GO:0005829)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:2779568^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000993)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:4052391^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000993) part_of:(UBERON:0002107) part_of:(UBERON:0000955) part_of:(UBERON:0001134)	Seeded From UniProt	complete
enables	GO:1990239	steroid hormone binding	PMID:4052391^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(UBERON:0000993) has_direct_input:(CHEBI:17026)	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:8300755^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(CL:0002132) part_of:(UBERON:0004245)	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	PMID:8300755^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(CL:0002132) part_of:(UBERON:0004245)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8300755^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0004804) part_of:(UBERON:0004245) part_of:(CL:0002132)	Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:2021645^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:2021645^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:2021645^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000993) part_of:(UBERON:0002107)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:8114727^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q90955	F		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:8114727^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11501	F		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	PMID:8114727^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:B3VHV2 UniProtKB:B6EAX2 UniProtKB:P08106 UniProtKB:Q7SX63	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:7476967^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000993)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:7476967^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E1BXG9	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11599567^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000993)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11599567^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	PMID:1892850^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0000993)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128 InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128 InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128 InterPro:IPR001628 InterPro:IPR001723	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128 InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000128	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07812	C	part_of:(UBERON:0000993) part_of:(UBERON:0002107) part_of:(UBERON:0000955) part_of:(UBERON:0001134)	Seeded From UniProt	complete
enables	GO:1990239	steroid hormone binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07812	F	occurs_in:(UBERON:0000993) has_direct_input:(CHEBI:17026)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07812	C	part_of:(UBERON:0004804) part_of:(UBERON:0004245) part_of:(CL:0002132)	Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07812	P	part_of:(CL:0002132) part_of:(UBERON:0004245)	Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07812	P	part_of:(CL:0002132) part_of:(UBERON:0004245)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07812	C	part_of:(UBERON:0000993) part_of:(UBERON:0002107)	Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07812	F		Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07812	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005496	steroid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0754	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Weaver, AJ et al. (2000) Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. J. Biol. Chem. 275 23045-52 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kost, SL et al. (1989) Binding of heat shock proteins to the avian progesterone receptor. Mol. Cell. Biol. 9 3829-38 PubMed GONUTS page
↑ ^3.0 ^3.1 Sullivan, WP et al. (1985) Isolation of steroid receptor binding protein from chicken oviduct and production of monoclonal antibodies. Biochemistry 24 4214-22 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Zhuang, YH et al. (1993) Immunohistochemical localization of the avian progesterone receptor and its candidate receptor binding factor (RBF-1). J. Cell. Biochem. 53 383-93 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Schuchard, M et al. (1991) Characterization of a purified chromatin acceptor protein (receptor binding factor 1) for the avian oviduct progesterone receptor. Biochemistry 30 4535-42 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Johnson, JL et al. (1994) Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol. Cell. Biol. 14 1956-63 PubMed GONUTS page
↑ ^7.0 ^7.1 Milad, M et al. (1995) Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. Mol. Endocrinol. 9 838-47 PubMed GONUTS page
↑ ^8.0 ^8.1 Haverinen, M et al. (2001) Heat shock protein 90 and the nuclear transport of progesterone receptor. Cell Stress Chaperones 6 256-62 PubMed GONUTS page
↑ Schuchard, M et al. (1991) Nuclear matrix localization and specific matrix DNA binding by receptor binding factor 1 of the avian oviduct progesterone receptor. Biochemistry 30 9516-22 PubMed GONUTS page

[PMID:10811660-1] 1.0 ^1.1 Weaver, AJ et al. (2000) Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. J. Biol. Chem. 275 23045-52 PubMed GONUTS page

[PMID:2779568-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kost, SL et al. (1989) Binding of heat shock proteins to the avian progesterone receptor. Mol. Cell. Biol. 9 3829-38 PubMed GONUTS page

[PMID:4052391-3] 3.0 ^3.1 Sullivan, WP et al. (1985) Isolation of steroid receptor binding protein from chicken oviduct and production of monoclonal antibodies. Biochemistry 24 4214-22 PubMed GONUTS page

[PMID:8300755-4] 4.0 ^4.1 ^4.2 Zhuang, YH et al. (1993) Immunohistochemical localization of the avian progesterone receptor and its candidate receptor binding factor (RBF-1). J. Cell. Biochem. 53 383-93 PubMed GONUTS page

[PMID:2021645-5] 5.0 ^5.1 ^5.2 Schuchard, M et al. (1991) Characterization of a purified chromatin acceptor protein (receptor binding factor 1) for the avian oviduct progesterone receptor. Biochemistry 30 4535-42 PubMed GONUTS page

[PMID:8114727-6] 6.0 ^6.1 ^6.2 Johnson, JL et al. (1994) Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol. Cell. Biol. 14 1956-63 PubMed GONUTS page

[PMID:7476967-7] 7.0 ^7.1 Milad, M et al. (1995) Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. Mol. Endocrinol. 9 838-47 PubMed GONUTS page

[PMID:11599567-8] 8.0 ^8.1 Haverinen, M et al. (2001) Heat shock protein 90 and the nuclear transport of progesterone receptor. Cell Stress Chaperones 6 256-62 PubMed GONUTS page

[PMID:1892850-9] Schuchard, M et al. (1991) Nuclear matrix localization and specific matrix DNA binding by receptor binding factor 1 of the avian oviduct progesterone receptor. Biochemistry 30 9516-22 PubMed GONUTS page

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CHICK:PRGR

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