CHICK:PITX2

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	PITX2 (synonyms: PTX2)
Protein Name(s)	Pituitary homeobox 2 Homeobox protein PITX2 cPITX2 Paired-like homeodomain transcription factor 2
External Links
UniProt	O93385
EMBL	AF076640 AF077092 AF063935
PIR	JW0097
RefSeq	NP_990341.1
UniGene	Gga.3398
ProteinModelPortal	O93385
SMR	O93385
STRING	9031.ENSGALP00000036884
GeneID	395862
KEGG	gga:395862
CTD	5308
eggNOG	NOG249113
HOVERGEN	HBG068770
InParanoid	O93385
KO	K04686
PhylomeDB	O93385
NextBio	20815929
PRO	PR:O93385
Proteomes	UP000000539
GO	GO:0005634 GO:0043565 GO:0003700 GO:0007368 GO:0030326 GO:0061184 GO:0045663 GO:2000288 GO:2000287 GO:0045944
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR016233 IPR009057 IPR003654
Pfam	PF00046 PF03826
PIRSF	PIRSF000563
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071 PS50803

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0008134	transcription factor binding	PMID:19850024^[1]	ECO:0000021		UniProtKB:O93345	F	Figure 1: Possible interaction is observed between Pitx2 and Lef-1	complete
	GO:0061055	myotome development	PMID:19850024^[1]	ECO:0000315			P	Figure 2 and 3 show the gene is clearly involved in myotome development.	complete
	GO:0061185	negative regulation of dermatome development	PMID:19850024^[1]	ECO:0000315			P	Figure 3: Misexpression caused an increased development in the dermatome development suggesting the gene to have a negative effect in vivo.	complete
	GO:0060174	limb bud formation	PMID:19850024^[1]	ECO:0000315			P	Figure 5 shows clear involvement of Pitx2 in the formation of the limb bud.	complete
involved_in	GO:0003007	heart morphogenesis	PMID:10500184^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001947	heart looping	PMID:10500184^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032526	response to retinoic acid	PMID:10500184^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000288	positive regulation of myoblast proliferation	PMID:19850024^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000287	positive regulation of myotome development	PMID:19850024^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061184	positive regulation of dermatome development	PMID:19850024^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19850024^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	PMID:19850024^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030326	embryonic limb morphogenesis	PMID:19850024^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007368	determination of left/right symmetry	PMID:9708732^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109340 PANTHER:PTN001551528 WB:WBGene00006766	F	Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109340 PANTHER:PTN001551528	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020912 MGI:MGI:107374 MGI:MGI:109340 MGI:MGI:1100498 PANTHER:PTN001551528 RGD:3331 RGD:3332 UniProtKB:P78337 UniProtKB:Q99697 WB:WBGene00006766	C	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001551528 UniProtKB:P78337 UniProtKB:Q99697	F	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107374 MGI:MGI:1100498 PANTHER:PTN001551528 RGD:3331	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR009057	F	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016233	F	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F	Seeded From UniProt	complete
involved_in	GO:0048562	embryonic organ morphogenesis	PMID:10500184^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	PMID:10500184^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Abu-Elmagd, M et al. (2010) Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis. Dev. Biol. 337 211-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tsukui, T et al. (1999) Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc. Natl. Acad. Sci. U.S.A. 96 11376-81 PubMed GONUTS page
↑ Yoshioka, H et al. (1998) Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 94 299-305 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19850024-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Abu-Elmagd, M et al. (2010) Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis. Dev. Biol. 337 211-9 PubMed GONUTS page

[PMID:10500184-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tsukui, T et al. (1999) Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc. Natl. Acad. Sci. U.S.A. 96 11376-81 PubMed GONUTS page

[PMID:9708732-3] Yoshioka, H et al. (1998) Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry. Cell 94 299-305 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

CHICK:PITX2

Contents

Annotations

Notes

References

a

c

d

e

g

h

l

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools