CHICK:P79994

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	No Information Provided.
Protein Name(s)	DNA topoisomerase I (ECO:0000313 with EMBL:BAA19101.1)
External Links
UniProt	P79994
EMBL	AB000407
RefSeq	NP_990441.1
UniGene	Gga.37721
ProteinModelPortal	P79994
SMR	P79994
STRING	9031.ENSGALP00000005822
PaxDb	P79994
PRIDE	P79994
GeneID	396004
KEGG	gga:396004
CTD	7150
eggNOG	COG3569
HOGENOM	HOG000105469
HOVERGEN	HBG007988
KO	K03163
PhylomeDB	P79994
NextBio	20816067
PRO	PR:P79994
ExpressionAtlas	P79994
GO	GO:0005737 GO:0005730 GO:0005654 GO:0005634 GO:0043204 GO:0031298 GO:0003682 GO:0003677 GO:0003917 GO:0003918 GO:0003690 GO:0006338 GO:0007059 GO:0006260 GO:0006265 GO:0040016
Gene3D	1.10.10.41 1.10.132.10 2.170.11.10 3.90.15.10
InterPro	IPR011010 IPR013034 IPR001631 IPR018521 IPR025834 IPR014711 IPR014727 IPR013500 IPR008336 IPR013030 IPR013499
Pfam	PF14370 PF01028 PF02919
PRINTS	PR00416
SMART	SM00435
SUPFAM	SSF56349 SSF56741
PROSITE	PS00176

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0006265	DNA topological change	PMID:6325181^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:6325181^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0045027	DNA end binding	PMID:6304657^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	PMID:6304657^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:6304657^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000786	nucleosome	PMID:2985626^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000793	condensed chromosome	PMID:2985625^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	PMID:2985049^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:2985049^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003917	DNA topoisomerase type I activity	PMID:2985049^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:9457068^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04750	C	Seeded From UniProt	complete
involved_in	GO:0040016	embryonic cleavage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04750	P	Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04750	P	Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04750	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04750	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04750	C	Seeded From UniProt	complete
enables	GO:0003917	DNA topoisomerase type I activity	PMID:6304657^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003917	DNA topoisomerase type I activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04750	F	Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:6304657^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11387	F	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11387	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11387	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11387	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001631 InterPro:IPR008336 InterPro:IPR011010 InterPro:IPR013030 InterPro:IPR013499 InterPro:IPR013500 InterPro:IPR014711 InterPro:IPR014727 InterPro:IPR018521 InterPro:IPR036202	F	Seeded From UniProt	complete
enables	GO:0003917	DNA topoisomerase type I activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001631 InterPro:IPR008336 InterPro:IPR013030 InterPro:IPR013034 InterPro:IPR013499 InterPro:IPR013500 InterPro:IPR014711 InterPro:IPR014727 InterPro:IPR018521 InterPro:IPR036202	F	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008336 InterPro:IPR013030 InterPro:IPR013499 InterPro:IPR014727 InterPro:IPR036202	C	Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001631 InterPro:IPR008336 InterPro:IPR013030 InterPro:IPR013034 InterPro:IPR013499 InterPro:IPR013500 InterPro:IPR014711 InterPro:IPR014727 InterPro:IPR018521 InterPro:IPR036202	P	Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR001079772	F	Seeded From UniProt	complete
enables	GO:0003917	DNA topoisomerase type I activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR001079772	F	Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR001079772	P	Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	PMID:6304657^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Trask, DK et al. (1984) Rapid detection and isolation of covalent DNA/protein complexes: application to topoisomerase I and II. EMBO J. 3 671-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Trask, DK & Muller, MT (1983) Biochemical characterization of topoisomerase I purified from avian erythrocytes. Nucleic Acids Res. 11 2779-800 PubMed GONUTS page
↑ Earnshaw, WC & Heck, MM (1985) Localization of topoisomerase II in mitotic chromosomes. J. Cell Biol. 100 1716-25 PubMed GONUTS page
↑ Earnshaw, WC et al. (1985) Topoisomerase II is a structural component of mitotic chromosome scaffolds. J. Cell Biol. 100 1706-15 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hoepfner, RW & Muller, MT (1985) Topoisomerase I is the predominant nuclear protein from avian erythrocytes that can be covalently linked to DNA. Biochem. J. 226 873-8 PubMed GONUTS page
↑ Muscarella, DE et al. (1998) Contribution of gene-specific lesions, DNA-replication-associated damage, and subsequent transcriptional inhibition in topoisomerase inhibitor-mediated apoptosis in lymphoma cells. Exp. Cell Res. 238 155-67 PubMed GONUTS page

[PMID:6325181-1] 1.0 ^1.1 Trask, DK et al. (1984) Rapid detection and isolation of covalent DNA/protein complexes: application to topoisomerase I and II. EMBO J. 3 671-6 PubMed GONUTS page

[PMID:6304657-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Trask, DK & Muller, MT (1983) Biochemical characterization of topoisomerase I purified from avian erythrocytes. Nucleic Acids Res. 11 2779-800 PubMed GONUTS page

[PMID:2985626-3] Earnshaw, WC & Heck, MM (1985) Localization of topoisomerase II in mitotic chromosomes. J. Cell Biol. 100 1716-25 PubMed GONUTS page

[PMID:2985625-4] Earnshaw, WC et al. (1985) Topoisomerase II is a structural component of mitotic chromosome scaffolds. J. Cell Biol. 100 1706-15 PubMed GONUTS page

[PMID:2985049-5] 5.0 ^5.1 ^5.2 Hoepfner, RW & Muller, MT (1985) Topoisomerase I is the predominant nuclear protein from avian erythrocytes that can be covalently linked to DNA. Biochem. J. 226 873-8 PubMed GONUTS page

[PMID:9457068-6] Muscarella, DE et al. (1998) Contribution of gene-specific lesions, DNA-replication-associated damage, and subsequent transcriptional inhibition in topoisomerase inhibitor-mediated apoptosis in lymphoma cells. Exp. Cell Res. 238 155-67 PubMed GONUTS page

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CHICK:P79994

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