CHICK:P3H1

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	LEPRE1 (synonyms: P3H1)
Protein Name(s)	Prolyl 3-hydroxylase 1 Leucine- and proline-enriched proteoglycan 1 homolog Leprecan-1 homolog
External Links
UniProt	Q6JHU8
EMBL	AY463528
RefSeq	NP_001001529.1
UniGene	Gga.9766
ProteinModelPortal	Q6JHU8
IntAct	Q6JHU8
STRING	9031.ENSGALP00000007707
PaxDb	Q6JHU8
Ensembl	ENSGALT00000007719
GeneID	414142
KEGG	gga:414142
CTD	64175
eggNOG	NOG269251
GeneTree	ENSGT00550000074573
HOVERGEN	HBG053224
InParanoid	Q6JHU8
KO	K08134
OMA	FNYLQFS
PhylomeDB	Q6JHU8
Reactome	REACT_198187
NextBio	20818679
PRO	PR:Q6JHU8
Proteomes	UP000000539
GO	GO:0005783 GO:0070062 GO:0032991 GO:0016020 GO:0005634 GO:0005506 GO:0031418 GO:0019797 GO:0032403 GO:0060348 GO:0016049 GO:0061077 GO:0030199 GO:0032963 GO:1901874 GO:0019511 GO:0050821 GO:0030278 GO:0050708
Gene3D	1.25.40.10
InterPro	IPR005123 IPR006620 IPR011990
Pfam	PF13640
SMART	SM00702
PROSITE	PS00014 PS51471

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0061077	chaperone-mediated protein folding	PMID:19419969^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_maturation_of:(GO:0005586)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19419969^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0005518	collagen binding	PMID:19419969^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1904027	negative regulation of collagen fibril organization	PMID:19419969^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032963	collagen metabolic process	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001422087 RGD:1304568 UniProtKB:Q6JHU8 UniProtKB:Q8IVL5	P		Seeded From UniProt	complete
enables	GO:0019797	procollagen-proline 3-dioxygenase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001422087 RGD:1304568 UniProtKB:Q6JHU8 UniProtKB:Q8IVL5	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001422087 UniProtKB:Q32P28 UniProtKB:Q6JHU8 UniProtKB:Q8IVL5	C		Seeded From UniProt	complete
involved_in	GO:0032963	collagen metabolic process	PMID:15044469^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019797	procollagen-proline 3-dioxygenase activity	PMID:15044469^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:15044469^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019511	peptidyl-proline hydroxylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0019797	P		Seeded From UniProt	complete
involved_in	GO:0019511	peptidyl-proline hydroxylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019797	P		Seeded From UniProt	complete
involved_in	GO:0019511	peptidyl-proline hydroxylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019797	P		Seeded From UniProt	complete
involved_in	GO:0019511	peptidyl-proline hydroxylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0019797	P		Seeded From UniProt	complete
involved_in	GO:1901874	negative regulation of post-translational protein modification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q32P28 ensembl:ENSP00000236040	P		Seeded From UniProt	complete
involved_in	GO:0060348	bone development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q32P28 ensembl:ENSP00000236040	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q32P28 ensembl:ENSP00000236040	P		Seeded From UniProt	complete
involved_in	GO:0050708	regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q32P28 ensembl:ENSP00000236040	P		Seeded From UniProt	complete
involved_in	GO:0018126	protein hydroxylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q32P28 ensembl:ENSP00000236040	P		Seeded From UniProt	complete
involved_in	GO:0006457	protein folding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q32P28 ensembl:ENSP00000236040	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q32P28 ensembl:ENSP00000236040	C		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006620	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005123	F		Seeded From UniProt	complete
enables	GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006620	F		Seeded From UniProt	complete
enables	GO:0019797	procollagen-proline 3-dioxygenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039837	F		Seeded From UniProt	complete
enables	GO:0031418	L-ascorbic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006620	F		Seeded From UniProt	complete
involved_in	GO:0032963	collagen metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039575	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005123 InterPro:IPR006620	P		Seeded From UniProt	complete
enables	GO:0019797	procollagen-proline 3-dioxygenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.11.7	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0031418	L-ascorbic acid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0847	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0223	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Ishikawa, Y et al. (2009) Biochemical characterization of the prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B complex. J. Biol. Chem. 284 17641-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Vranka, JA et al. (2004) Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes. J. Biol. Chem. 279 23615-21 PubMed GONUTS page

[PMID:19419969-1] 1.0 ^1.1 ^1.2 ^1.3 Ishikawa, Y et al. (2009) Biochemical characterization of the prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B complex. J. Biol. Chem. 284 17641-7 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15044469-3] 3.0 ^3.1 ^3.2 Vranka, JA et al. (2004) Prolyl 3-hydroxylase 1, enzyme characterization and identification of a novel family of enzymes. J. Biol. Chem. 279 23615-21 PubMed GONUTS page

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CHICK:P3H1

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