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CHICK:O93288

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) TBX4 (ECO:0000313 with EMBL:AAC41298.1)
Protein Name(s) T-Box protein 4 (ECO:0000313 with EMBL:AAC41298.1)
External Links
UniProt O93288
EMBL AF033670
RefSeq NP_001025708.1
UniGene Gga.489
ProteinModelPortal O93288
SMR O93288
IntAct O93288
STRING 9031.ENSGALP00000008461
PaxDb O93288
GeneID 373989
KEGG gga:373989
CTD 9496
eggNOG NOG320009
HOVERGEN HBG007310
KO K10178
PhylomeDB O93288
NextBio 20813518
GO GO:0005634
GO:0003677
GO:0003700
GO:0035108
GO:0048705
GO:0006351
Gene3D 2.60.40.820
InterPro IPR008967
IPR001699
IPR018186
PANTHER PTHR11267
Pfam PF00907
PRINTS PR00937
SMART SM00425
SUPFAM SSF49417
PROSITE PS01283
PS01264
PS50252

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0010468

regulation of gene expression

PMID:12736216[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060174

limb bud formation

PMID:12736216[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005884

actin filament

PMID:15302601[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0035116

embryonic hindlimb morphogenesis

PMID:12736216[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0001725

stress fiber

PMID:15302601[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15302601[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15302601[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030274

LIM domain binding

PMID:15302601[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:R4GKC8

F

Seeded From UniProt

complete

enables

GO:0030274

LIM domain binding

PMID:15302601[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q679P3

F

Seeded From UniProt

complete

involved_in

GO:0048705

skeletal system morphogenesis

PMID:10945475[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P57082

P

Seeded From UniProt

complete

involved_in

GO:0035108

limb morphogenesis

PMID:10945475[3]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P57082

P

Seeded From UniProt

complete

involved_in

GO:0048705

skeletal system morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P57082
ensembl:ENSP00000377435

P

Seeded From UniProt

complete

involved_in

GO:0035108

limb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P57082
ensembl:ENSP00000377435

P

Seeded From UniProt

complete

involved_in

GO:0035108

limb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70325
ensembl:ENSMUSP00000103682

P

Seeded From UniProt

complete

involved_in

GO:0030326

embryonic limb morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70325
ensembl:ENSMUSP00000103682

P

Seeded From UniProt

complete

involved_in

GO:0030324

lung development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70325
ensembl:ENSMUSP00000103682

P

Seeded From UniProt

complete

involved_in

GO:0002009

morphogenesis of an epithelium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70325
ensembl:ENSMUSP00000103682

P

Seeded From UniProt

complete

involved_in

GO:0001525

angiogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70325
ensembl:ENSMUSP00000103682

P

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001699
InterPro:IPR008967
InterPro:IPR018186
InterPro:IPR036960

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001699
InterPro:IPR018186
InterPro:IPR036960

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001699
InterPro:IPR008967
InterPro:IPR018186
InterPro:IPR036960

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000040

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000400702

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000400702

C

Seeded From UniProt

complete

involved_in

GO:0035136

forelimb morphogenesis

PMID:15302601[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Takeuchi, JK et al. (2003) Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade. Development 130 2729-39 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Krause, A et al. (2004) Tbx5 and Tbx4 transcription factors interact with a new chicken PDZ-LIM protein in limb and heart development. Dev. Biol. 273 106-20 PubMed GONUTS page
  3. 3.0 3.1 Yi, CH et al. (2000) Virtual cloning and physical mapping of a human T-box gene, TBX4. Genomics 67 92-5 PubMed GONUTS page