CHICK:O42124

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	BRK-3 (ECO:0000313 with EMBL:BAA22057.1)
Protein Name(s)	BMP type II receptor (ECO:0000313 with EMBL:BAA22057.1) Type II bone morphogenetic protein receptor (ECO:0000313 with EMBL:AAL40035.1)
External Links
UniProt	O42124
EMBL	L77660 AB006785
RefSeq	NP_001001465.1
UniGene	Gga.105
ProteinModelPortal	O42124
SMR	O42124
STRING	9031.ENSGALP00000013771
GeneID	374147
KEGG	gga:374147
CTD	659
eggNOG	COG0515
HOGENOM	HOG000043088
HOVERGEN	HBG050705
InParanoid	O42124
KO	K04671
OrthoDB	EOG7JHM5B
PhylomeDB	O42124
TreeFam	TF314724
NextBio	20813661
PRO	PR:O42124
GO	GO:0016021 GO:0005524 GO:0004702 GO:0005024 GO:0002063 GO:1902731
InterPro	IPR000472 IPR015770 IPR011009 IPR000719 IPR017441 IPR000333
PANTHER	PTHR23255 PTHR23255:SF63
Pfam	PF01064 PF00069
SUPFAM	SSF56112
PROSITE	PS00107 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0060350	endochondral bone morphogenesis	PMID:8951071^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	PMID:8951071^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030166	proteoglycan biosynthetic process	PMID:8951071^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1902731	negative regulation of chondrocyte proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13873	P	Seeded From UniProt	complete
involved_in	GO:0002063	chondrocyte development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13873	P	Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13873	P	Seeded From UniProt	complete
involved_in	GO:1905314	semi-lunar valve development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
enables	GO:0098821	BMP receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	F	Seeded From UniProt	complete
involved_in	GO:0061626	pharyngeal arch artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0061298	retina vasculature development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0060841	venous blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0060840	artery development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0060836	lymphatic endothelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0060413	atrial septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0060173	limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0048842	positive regulation of axon extension involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0048286	lung alveolus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0045906	negative regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0014916	regulation of lung blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	C	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	C	Seeded From UniProt	complete
involved_in	GO:0009952	anterior/posterior pattern specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	C	Seeded From UniProt	complete
involved_in	GO:0003252	negative regulation of cell proliferation involved in heart valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0003197	endocardial cushion development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0003186	tricuspid valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0003183	mitral valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:0001707	mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35607 ensembl:ENSMUSP00000084701	P	Seeded From UniProt	complete
involved_in	GO:2000279	negative regulation of DNA biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:1902731	negative regulation of chondrocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0072577	endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0045669	positive regulation of osteoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
enables	GO:0036122	BMP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	F	Seeded From UniProt	complete
involved_in	GO:0030513	positive regulation of BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0014916	regulation of lung blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
part_of	GO:0005913	cell-cell adherens junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	C	Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	C	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	C	Seeded From UniProt	complete
involved_in	GO:0003085	negative regulation of systemic arterial blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0002063	chondrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0001938	positive regulation of endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
involved_in	GO:0001935	endothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13873 ensembl:ENSP00000363708	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F	Seeded From UniProt	complete
enables	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P	Seeded From UniProt	complete
involved_in	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000333 InterPro:IPR000472	C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kawakami, Y et al. (1996) BMP signaling during bone pattern determination in the developing limb. Development 122 3557-66 PubMed GONUTS page

[PMID:8951071-1] 1.0 ^1.1 ^1.2 Kawakami, Y et al. (1996) BMP signaling during bone pattern determination in the developing limb. Development 122 3557-66 PubMed GONUTS page

[1]

CHICK:O42124

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