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CHICK:NRAM1
Contents
Species (Taxon ID) | Gallus gallus (Chicken). (9031) | |
Gene Name(s) | SLC11A1 (synonyms: NRAMP1) | |
Protein Name(s) | Natural resistance-associated macrophage protein 1
NRAMP 1 Solute carrier family 11 member 1 | |
External Links | ||
UniProt | P51027 | |
EMBL | U40598 S82465 | |
RefSeq | NP_990295.1 | |
UniGene | Gga.477 | |
Ensembl | ENSGALT00000018648 | |
GeneID | 395811 | |
KEGG | gga:395811 | |
CTD | 6556 | |
eggNOG | COG1914 | |
GeneTree | ENSGT00390000006526 | |
HOGENOM | HOG000152203 | |
HOVERGEN | HBG052665 | |
InParanoid | P51027 | |
KO | K12347 | |
OMA | TSMPTLM | |
PhylomeDB | P51027 | |
Reactome | REACT_196277 REACT_238005 | |
NextBio | 20815879 | |
PRO | PR:P51027 | |
Proteomes | UP000000539 | |
ExpressionAtlas | P51027 | |
GO | GO:0009279 GO:0010008 GO:0016021 GO:0005770 GO:0005764 GO:0030670 GO:0005886 GO:0070821 GO:0005384 GO:0051139 GO:0046915 GO:0032147 GO:0048002 GO:0070574 GO:0006876 GO:0006879 GO:0050829 GO:0042832 GO:0070839 GO:0006954 GO:0032623 GO:0032632 GO:0006826 GO:0043091 GO:0042116 GO:0045342 GO:0048255 GO:0060586 GO:0001818 GO:0015707 GO:0006909 GO:0002606 GO:0032729 GO:0050766 GO:0002827 GO:0045944 GO:0000060 GO:0045730 GO:0034341 GO:0002369 GO:0002309 GO:0007035 GO:0042060 | |
HAMAP | MF_00221 | |
InterPro | IPR001046 | |
PANTHER | PTHR11706 | |
Pfam | PF01566 | |
PRINTS | PR00447 | |
TIGRFAMs | TIGR01197 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0005635 |
nuclear envelope |
ECO:0000314 |
C |
complete | ||||||
involved_in |
GO:0070574 |
cadmium ion transmembrane transport |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0015086 |
cadmium ion transmembrane transporter activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006829 |
zinc ion transport |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005385 |
zinc ion transmembrane transporter activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070839 |
divalent metal ion export |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070574 |
cadmium ion transmembrane transport |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051139 |
metal ion:proton antiporter activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046915 |
transition metal ion transmembrane transporter activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006876 |
cellular cadmium ion homeostasis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0051139 |
metal ion:proton antiporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000194440 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000194440 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1345275 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030670 |
phagocytic vesicle membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1345275 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0015086 |
cadmium ion transmembrane transporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG14157 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009617 |
response to bacterium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1345275 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1345275 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006876 |
cellular cadmium ion homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000194440 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1345279 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005384 |
manganese ion transmembrane transporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG14157 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005384 |
manganese ion transmembrane transporter activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG14157 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071421 |
manganese ion transmembrane transport |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005384 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071421 |
manganese ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005384 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071421 |
manganese ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005384 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071577 |
zinc ion transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005385 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902023 |
L-arginine transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070839 |
divalent metal ion export |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060586 |
multicellular organismal iron ion homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055072 |
iron ion homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050766 |
positive regulation of phagocytosis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048255 |
mRNA stabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0048002 |
antigen processing and presentation of peptide antigen |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045730 |
respiratory burst |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045342 |
MHC class II biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042832 |
defense response to protozoan |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042742 |
defense response to bacterium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042116 |
macrophage activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042060 |
wound healing |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0034341 |
response to interferon-gamma |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032729 |
positive regulation of interferon-gamma production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032632 |
interleukin-3 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032623 |
interleukin-2 production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032147 |
activation of protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0030670 |
phagocytic vesicle membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0015707 |
nitrite transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0010008 |
endosome membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009617 |
response to bacterium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007035 |
vacuolar acidification |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006909 |
phagocytosis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006828 |
manganese ion transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006826 |
iron ion transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005770 |
late endosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005764 |
lysosome |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005384 |
manganese ion transmembrane transporter activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002827 |
positive regulation of T-helper 1 type immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002606 |
positive regulation of dendritic cell antigen processing and presentation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002369 |
T cell cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0002309 |
T cell proliferation involved in immune response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001819 |
positive regulation of cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001818 |
negative regulation of cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41251 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0070821 |
tertiary granule membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070574 |
cadmium ion transmembrane transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0051139 |
metal ion:proton antiporter activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0046915 |
transition metal ion transmembrane transporter activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0030670 |
phagocytic vesicle membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009617 |
response to bacterium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006879 |
cellular iron ion homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006876 |
cellular cadmium ion homeostasis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006826 |
iron ion transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P49279 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030001 |
metal ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0046873 |
metal ion transmembrane transporter activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055072 |
iron ion homeostasis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Techau, ME et al. (2007) Evolution of differences in transport function in Slc11a family members. J. Biol. Chem. 282 35646-56 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
a
c
d
i
m
- GO:0042116 ! macrophage activation
- GO:0071421 ! manganese ion transmembrane transport
- GO:0005384 ! manganese ion transmembrane transporter activity
- GO:0006828 ! manganese ion transport
- GO:0016020 ! membrane
- GO:0051139 ! metal cation:proton antiporter activity
- GO:0070839 ! metal ion export
- GO:0046873 ! metal ion transmembrane transporter activity
- GO:0030001 ! metal ion transport
- Metazoa
- GO:0045342 ! MHC class II biosynthetic process
- GO:0006811 ! monoatomic ion transport
- GO:0048255 ! mRNA stabilization
- GO:0060586 ! multicellular organismal-level iron ion homeostasis
n
o
p
- GO:0030670 ! phagocytic vesicle membrane
- GO:0006909 ! phagocytosis
- Phasianidae
- Phasianinae
- GO:0005886 ! plasma membrane
- GO:0002827 ! positive regulation of T-helper 1 type immune response
- GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation
- GO:0050766 ! positive regulation of phagocytosis
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0032729 ! positive regulation of type II interferon production
- GO:0010628 ! positive regulation of gene expression
- GO:0001819 ! positive regulation of cytokine production
- GO:0042803 ! protein homodimerization activity
r
t