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CHICK:NRAM1

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Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) SLC11A1 (synonyms: NRAMP1)
Protein Name(s) Natural resistance-associated macrophage protein 1

NRAMP 1 Solute carrier family 11 member 1

External Links
UniProt P51027
EMBL U40598
S82465
RefSeq NP_990295.1
UniGene Gga.477
Ensembl ENSGALT00000018648
GeneID 395811
KEGG gga:395811
CTD 6556
eggNOG COG1914
GeneTree ENSGT00390000006526
HOGENOM HOG000152203
HOVERGEN HBG052665
InParanoid P51027
KO K12347
OMA TSMPTLM
PhylomeDB P51027
Reactome REACT_196277
REACT_238005
NextBio 20815879
PRO PR:P51027
Proteomes UP000000539
ExpressionAtlas P51027
GO GO:0009279
GO:0010008
GO:0016021
GO:0005770
GO:0005764
GO:0030670
GO:0005886
GO:0070821
GO:0005384
GO:0051139
GO:0046915
GO:0032147
GO:0048002
GO:0070574
GO:0006876
GO:0006879
GO:0050829
GO:0042832
GO:0070839
GO:0006954
GO:0032623
GO:0032632
GO:0006826
GO:0043091
GO:0042116
GO:0045342
GO:0048255
GO:0060586
GO:0001818
GO:0015707
GO:0006909
GO:0002606
GO:0032729
GO:0050766
GO:0002827
GO:0045944
GO:0000060
GO:0045730
GO:0034341
GO:0002369
GO:0002309
GO:0007035
GO:0042060
HAMAP MF_00221
InterPro IPR001046
PANTHER PTHR11706
Pfam PF01566
PRINTS PR00447
TIGRFAMs TIGR01197

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005635

nuclear envelope

PMID:17932044[1]

ECO:0000314

C

complete

involved_in

GO:0070574

cadmium ion transmembrane transport

PMID:17932044[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P38356

P

Seeded From UniProt

complete

enables

GO:0015086

cadmium ion transmembrane transporter activity

PMID:17932044[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P38356

F

Seeded From UniProt

complete

involved_in

GO:0006829

zinc ion transport

PMID:17932044[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P38356

P

Seeded From UniProt

complete

enables

GO:0005385

zinc ion transmembrane transporter activity

PMID:17932044[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P38356

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:17932044[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

PMID:17932044[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070839

divalent metal ion export

PMID:17932044[1]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P41251

P

Seeded From UniProt

complete

involved_in

GO:0070574

cadmium ion transmembrane transport

PMID:17932044[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P38356

P

Seeded From UniProt

complete

enables

GO:0051139

metal ion:proton antiporter activity

PMID:17932044[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P38356

F

Seeded From UniProt

complete

enables

GO:0046915

transition metal ion transmembrane transporter activity

PMID:17932044[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P38356

F

Seeded From UniProt

complete

involved_in

GO:0006876

cellular cadmium ion homeostasis

PMID:17932044[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P38356

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:17932044[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0051139

metal ion:proton antiporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000194440
UniProtKB:P49279
UniProtKB:P51027

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000194440
UniProtKB:P49279

F

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1345275
PANTHER:PTN000194440
UniProtKB:O77741

P

Seeded From UniProt

complete

part_of

GO:0030670

phagocytic vesicle membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1345275
PANTHER:PTN000194440
UniProtKB:P49279

C

Seeded From UniProt

complete

enables

GO:0015086

cadmium ion transmembrane transporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG14157
PANTHER:PTN000194431
RGD:3684
TAIR:locus:2025677
TAIR:locus:2200437
UniProtKB:P49281
UniProtKB:P51027

F

Seeded From UniProt

complete

involved_in

GO:0009617

response to bacterium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1345275
PANTHER:PTN000194440
UniProtKB:O77741
UniProtKB:P49279

P

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1345275
PANTHER:PTN000194440
UniProtKB:P49279

P

Seeded From UniProt

complete

involved_in

GO:0006876

cellular cadmium ion homeostasis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000194440
UniProtKB:P49279
UniProtKB:P51027

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1345279
PANTHER:PTN000194437
UniProtKB:P49279
UniProtKB:P49281
UniProtKB:P51027

C

Seeded From UniProt

complete

enables

GO:0005384

manganese ion transmembrane transporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG14157
FB:FBgn0011672
MGI:MGI:1345275
PANTHER:PTN000194431
RGD:3684
TAIR:locus:2025677
TAIR:locus:2036751
UniProtKB:P49281
UniProtKB:Q6ZG85

F

Seeded From UniProt

complete

enables

GO:0005384

manganese ion transmembrane transporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG14157
FB:FBgn0011672
MGI:MGI:1345275
PANTHER:PTN000194431
RGD:3684
TAIR:locus:2025677
TAIR:locus:2036751
UniProtKB:P49281

F

Seeded From UniProt

complete

involved_in

GO:0071421

manganese ion transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005384

P

Seeded From UniProt

complete

involved_in

GO:0071421

manganese ion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005384

P

Seeded From UniProt

complete

involved_in

GO:0071421

manganese ion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005384

P

Seeded From UniProt

complete

involved_in

GO:0071577

zinc ion transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005385

P

Seeded From UniProt

complete

involved_in

GO:1902023

L-arginine transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0070839

divalent metal ion export

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0060586

multicellular organismal iron ion homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0055072

iron ion homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0050829

defense response to Gram-negative bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0050766

positive regulation of phagocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0048255

mRNA stabilization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0048002

antigen processing and presentation of peptide antigen

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0045730

respiratory burst

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0045342

MHC class II biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0042832

defense response to protozoan

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0042116

macrophage activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0034341

response to interferon-gamma

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0032729

positive regulation of interferon-gamma production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0032632

interleukin-3 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0032623

interleukin-2 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

part_of

GO:0030670

phagocytic vesicle membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

C

Seeded From UniProt

complete

involved_in

GO:0015707

nitrite transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

part_of

GO:0010008

endosome membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

C

Seeded From UniProt

complete

involved_in

GO:0009617

response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0007035

vacuolar acidification

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0006909

phagocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0006828

manganese ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0006826

iron ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

part_of

GO:0005770

late endosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

C

Seeded From UniProt

complete

enables

GO:0005384

manganese ion transmembrane transporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

F

Seeded From UniProt

complete

involved_in

GO:0002827

positive regulation of T-helper 1 type immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0002606

positive regulation of dendritic cell antigen processing and presentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0002369

T cell cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0002309

T cell proliferation involved in immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0001819

positive regulation of cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

involved_in

GO:0001818

negative regulation of cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41251
ensembl:ENSMUSP00000027368

P

Seeded From UniProt

complete

part_of

GO:0070821

tertiary granule membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

C

Seeded From UniProt

complete

involved_in

GO:0070574

cadmium ion transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

P

Seeded From UniProt

complete

enables

GO:0051139

metal ion:proton antiporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

F

Seeded From UniProt

complete

enables

GO:0046915

transition metal ion transmembrane transporter activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

F

Seeded From UniProt

complete

part_of

GO:0030670

phagocytic vesicle membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

C

Seeded From UniProt

complete

involved_in

GO:0009617

response to bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

P

Seeded From UniProt

complete

involved_in

GO:0006879

cellular iron ion homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

P

Seeded From UniProt

complete

involved_in

GO:0006876

cellular cadmium ion homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

P

Seeded From UniProt

complete

involved_in

GO:0006826

iron ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P49279
ensembl:ENSP00000233202

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001046

C

Seeded From UniProt

complete

involved_in

GO:0030001

metal ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001046

P

Seeded From UniProt

complete

enables

GO:0046873

metal ion transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001046

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

involved_in

GO:0055072

iron ion homeostasis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0410

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Techau, ME et al. (2007) Evolution of differences in transport function in Slc11a family members. J. Biol. Chem. 282 35646-56 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page